Epigenetics: Mechanisms and Clinical Perspectives

Yildiz Dincer, PhD (Editor)
Istanbul University- Cerrahpasa, Cerrahpasa Medical Faculty, Department of Medical Biochemistry, Istanbul, Turkey

Series: Genetics – Research and Issues
BISAC: MED107000

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Epigenetics is a relatively new field of science explaining heritable changes that are not caused by alterations in DNA sequences. Epigenetic modifications are acquired throughout life, and depend on environmental clues such as diet, lifestyle and toxin exposure. It is possible to pass down epigenetic modifications to the next generation of offspring if the modifications occur in sperm or egg cells. Additionally, epigenetic regulations are central to many cellular processes such as imprinting, X chromosome inactivation, DNA damage response, cellular reprogramming and senescence. This book provides an overview for the influence of early life nutrition on the epigenome and the role of epigenetic dysregulations in the pathogenesis of many common diseases.
(Imprint: Nova Biomedical)

Preface

Chapter 1
Epigenetic Modifications and Developmental Origin of Health and Diseases (DOHaD)
(Jia Zheng and Xinhua Xiao, Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, and others)

Chapter 2
Effects of Oxidative Stress on Epigenetic Mechanisms
(Yildiz Dincer, and Onur Baykara, Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Biochemistry, Istanbul, Turkey, and others)

Chapter 3
Epigenetic Modifications and Their Potential Role in Tumorigenesis
(Muthu K. Shanmugam, Frank Arfuso, and Gautam Sethi, Associate Professor, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, and others)

Chapter 4
Alzheimer’s Disease: An Insight from Epigenetic Perspective
(Yildiz Dincer, and Zeynep Sezgin, Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Biochemistry, Istanbul, Turkey, and others)

Chapter 5
Epigenetic Mechanisms in Cardiovascular Diseases
(Mehmet Güven, and Bahadir Batar, Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey, and others)

Chapter 6
Insights from Epigenomics Analysis of Sperm: Sperm Development and Male Infertility
(Dheepa Balasubramanian, Eisa Tahmasbpour, Ashok Agarwal, Case Western Reserve University, Cleveland, OH, USA, and others)

Chapter 7
Epigenetics, Inflammation and Inflammation-Associated Diseases: A General Look
(Müge Sayitoğlu and Yücel Erbilgin, Istanbul University, Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey)

Chapter 8
A New Molecular Approach to Obesity: Epigenetic Perspective
(Burcu Bayoglu and Mujgan Cengiz, Istanbul University Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul, Turkey)

Index

Principal audiences of this book may be clinicans; students of medicine, pharmacology, molecular biology, genetics, dietetics; and students of Master and Ph.D. in the same areas; all scientist/investigators who have an career in molecular biology, pharmacology and dietetics.

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