Epigenetics: Beyond the Genetics and Medicine

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Sevgi Durna Daştan – Associate Professor, Faculty of Science, Department of Biology, Division of Molecular Biology, Sivas Cumhuriyet University, Sivas, Turkey
Nazan Yurtcu – Assistant Professor, Faculty of Medicine, Department of Obstetrics and Gynecology, Sivas Cumhuriyet University, Sivas, Turkey

Series: Genetics – Research and Issues
BISAC: MED107000
DOI: 10.52305/IVZP1313

Epigenetics refers to the study of changes in organisms that are caused by modifications of gene expression instead of alteration of the genetic code itself. This volume includes 30 chapters that explore epigenetics from a variety of perspectives, including the role of epigenetics in aging, cancers, fetal brain development, epilepsy, and more.

Table of Contents

Preface

Chapter 1. The Concept of Epigenetics
Tunay Karan
Department of Genetics, Yozgat Bozok University, Yozgat, Turkey

Chapter 2. The Relationship between Epigenetics and Diseases/Disorders
Nilsun Kuas, MD
Department of Pediatric Surgery- Pediatric Urology, Ankara University, Ankara, Turkey

Chapter 3. The Role of DNA Methylation and Histone Modifications in Oncogenesis
Gözde Öztan, PhD
Department of Medicine, Istanbul University, Istanbul, Turkey

Chapter 4. Epigenetic Effects of MicroRNAs in Oncogenesis
Muhammed Recai Akdoğan¹, MD and Necip Nas², MD
¹Department of Internal Medicine, Ataturk University, Erzurum, Turkey
²Department of Internal Medicine, Private Siirt Hayat Hospital, Siirt, Turkey

Chapter 5. The Concepts of Epigenomics and Cell Epigenomes
Taner Daştan¹, PhD and İnanç Baral², PhD
¹Department of Biochemistry, Faculty of Science, Sivas Cumhuriyet University, Sivas, Turkey
²Department of Zootechnics and Animal Nutrition, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Turkey

Chapter 6. The Role of Epigenetics in Cancers
İkbal Cansu Barış
Department of Medical Biology, University of Pamukkale, Denizli, Turkey

Chapter 7. Epigenetics and Microbiota
Özlem Aldemir, MD
Department of Infectious Diseases and Clinical Microbiology, Sivas Medicana Hospital, Sivas, Turkey

Chapter 8. The Role of Non-Coding RNAs in Epigenetic Mechanisms
Gözde Öztan, PhD
Department of Medicine, Istanbul University, Istanbul, Turkey

Chapter 9. General Overview of the Current Methodology in Epigenetics Research
Buket Er Urgancı
Department of Medical Biology, University of Pamukkale, Denizli, Turkey

Chapter 10. Computational Modeling of Epigenetics
Mesude Avci, PhD
Department of Chemical Engineering, Sivas Cumhuriyet University, Sivas, Turkey

Chapter 11. The Role of Epigenetics in Aging
Yusuf Muhammed Durna, MD, and Dilek Arslan Ateşşahin, PhD
Department of Otolaryngology and Head and Neck Surgery, Private Practice, Istanbul, Turkey
Department of Plant and Animal Production, Baskil Vocational School, Firat University, Elazığ, Turkey

Chapter 12. Epigenetics and Familial Mediterranean Fever
Ekin B. Doğancı, MD
Department of Physical Medicine and Rehabilitation, Department of Rheumatology Sivas Cumhuriyet University, Sivas, Turkey

Chapter 13. Epigenetics in Neurobiological and Neurobehavioral Diseases
Aslihan Sanri, MD
Department of Pediatric Genetics, Samsun Education and Research Hospital, Samsun, Turkey

Chapter 14. The Role of Epigenetics in Fetal Brain Development
Fatih Kılıcbay¹, MD, and Huseyin Erdal², PhD
¹Division of Neonatology, Department of Pediatrics, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey
²Department of Medical Genetics, Faculty of Medicine, Aksaray University, Aksaray, Turkey

Chapter 15. Epilepsy and Epigenetics
Arzuhan Cetindag Ciltas, PhD
Sivas Cumhuriyet University Vocational School of Health Services, Department of Therapy and Rehabilitation, Turkey

Chapter 16. Epigenetics and Cardiovascular Diseases
Yücel Karaca, MD and Çetin Mirzaoğlu, MD
Department of Cardiology, Elazığ Fethi Sekin City Hospital, Elazığ, Turkey

Chapter 17. Epigenetics and Obesity
Handan Sarac , PhD
Department of Plant and Animal Production, Sivas Cumhuriyet University, Sivas, Turkey

Chapter 18. Epigenetics and Diabetes
Zeynep Tüzün¹, MDand Serpil Çiftel², MD
¹Department of Internal Medicine, Ataturk University, Erzurum, Turkey
²Department of Endocrinology, Erzurum City Hospital, Erzurum, Turkey

Chapter 19. The Role of Epigenetics in Osteoporosis
Öner Kılınç, MD
Department of Orthopaedics and Traumatology, Mersin City Hospital,
Mersin, Turkey

Chapter 20. The Role of Epigenetics in Osteoarthritis
Fatih Günaydın, MD
Department of Orthopaedic Surgery, Mersin City Hospital, Mersin, Turkey

Chapter 21. Effect of Epigenetic Factors on Degenerative Disc Disease
Uğur Özdemir, MD
Orthopedics and Traumatology Clinic, Simav Doç. Dr. İsmail Karakuyu State Hospital, Kütahya, Turkey

Chapter 22. Epigenetics in Scoliosis
Ömer Bozduman¹, MD and Selim Görgün², MD
¹Department of Orthopedics and Traumatology, Samsun Training and Research Hospital, Samsun University, Samsun, Turkey
²Department of Microbiology and Clinical Microbiology, Samsun Training and Research Hospital, Samsun University, Samsun, Turkey

Chapter 23. Epigenetics in Endometriosis and Endometrial Cancer
Neşe Yeldir, MD
Department of Pathology, Cumhuriyet University, Sivas, Turkey

Chapter 24. Epigenetics in PCOS
Sultan Salk, MD
Department of Obstetrics and Gynecology, Sivas Medicana Hospital, Sivas, Turkey

Chapter 25. Epigenetics and Preeclampsia
Aslihan Yurtkal and Mujde Canday
Kafkas University, Faculty of Medicine, Department of Gynecology and Obstetrics, Kars, Turkey

Chapter 26. Epigenetics and Pain
Emel Guler, MD
Department of Physical Medicine and Rehabilitation, Division of Pain Management Section, Sivas Cumhuriyet University, Sivas, Turkey

Chapter 27. Epigenetics and Connective Tissue Diseases
Ali Erhan Özdemirel , MD
Department of Rheumatology, Liv Hospital, Ankara, Turkey

Chapter 28. Epigenetics and Rheumatoid Arthritis (RA)
Alper Doğancı, MD
Sivas Cumhuriyet University, Department of Physical Medicine and Rehabilitation, Department of Rheumatology, Sivas, Turkey

Chapter 29. Inflammatory Bowel Diseases and Epigenetics
İlkay Güler, MD
Department of General Surgery, Kayseri City Hospital, Kayseri, Turkey

Chapter 30. Epigenetic Factors and Surgical Approaches in Gastric Cancers
Pınar Koçatakan, MD
T. R. Ministry of Health Ankara Yenimahalle Training and Research Hospital Department of General Surgery, General Directorate of Public Hospitals Department of Health Services, Ankara, Turkey

Index