Asuman Canak, PhD – Department of Medical Services and Techniques, Vocational School of Health Services, Recep Tayyip Erdoğan University, Rize, Turkiye
Kerimali Akyildiz, PhD – Department of Medical Services and Techniques, Vocational School of Health Services, Recep Tayyip Erdoğan University, Rize, Turkiye

Series: Biochemistry Research Trends; Biochemistry and Molecular Biology in the Post Genomic Era
BISAC: SCI007000; MED075000; SCI049000
DOI: https://doi.org/10.52305/TNPM3817

This book, Epigallocatechin-3-Gallate (EGCG): From Biochemical Pathways to Physiological Outcomes, contains four chapters that detail epigallocatechin gallate (EGCG), a compound found in tea leaves, its effects on health, and future directions. Chapter 1 discusses the tea plant (Camellia sinensis L), the process of tea production, the types of tea, and the components found in tea. Chapter 2 focuses on EGCG, a highly potent polyphenolic compound present in tea that exhibits a broad spectrum of biological effects on human health. Chapter 3 expands on EGCG, arguing that EGCG is better understood as a distributed, network-level regulator acting simultaneously across the gut–liver axis, neuro–immune crosstalk, cardiovascular–renal–endocrine integration, and cellular senescence rather than as a compound with one dominant molecular target. Finally, chapter 4 discusses the gap between EGCG’s clinical translation as a network-level regulator of redox, inflammatory, and metabolic signaling, and argues that this gap may reflect not simply a deficiency in biological efficacy but an incomplete match between EGCG’s context-dependent pharmacology and the single-target, fixed-exposure assumptions of conventional translational pharmacology.

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