Epidermolysis Bullosa (EB): Prevalence, Clinical Manifestations and Management

Hubert Mullins (Editor)

Series: Dermatology – Laboratory and Clinical Research
BISAC: MED017000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Epidermolysis bullosa (EB) consists of few mechanobullous diseases of the skin and the mucous membranes, which clinically present with blisters, erosions, scarring and milia formation at the sites of minor trauma. Hereditary forms of EB are observed at birth or early childhood and are related to genetic defects leading to absence or insufficient expression of certain antigen determinants in the region of the basement membrane zone (BMZ). In contrast, the acquired forms of EB appear in adults and the development of the disease is related to autoimmunity towards the same antigen structures. This book examines the prevalence, clinical manifestations and management of EB.

The first chapter of the book examines epidermolysis bullosa acquisita. Chapter two studies immunofluorescence mapping for the diagnosis of inherited EB. Chapter three discusses nutrition for children and adolescents with EB. Chapter four provides an overview of wound healing and skin care in inherited EB. The final chapter reviews the main therapies currently under development for recessive dystrophic epidermolysis bullosa (RDEB) and focuses on recent advances in approaches combining gene therapy and tissue engineering for treating RDEB.
(Imprint: Nova Biomedical)

Preface

Chapter 1
Epidermolysis Bullosa Acquisita
(Kossara Drenovska, Snejina Vassileva, Department of Dermatology, Sofia University of Medicine, Sofia, Bulgaria)

Chapter 2
Immunofluorescence Mapping for Diagnosis of Inherited Epidermolysis Bullosa
(Valeria Mateeva, Grisha Mateev, and Snejina Vassileva, Department of Dermatology, Military Academy of Medicine, Sofia, Bulgaria, and others)

Chapter 3
Nutrition for Children and Adolescents with Epidermolysis Bullosa
(Ana Paula Caio Zidório, Eliane Said Dutra, Kênia Mara Baiocchi de Carvalho, Unidade de Nutrição Clínica, Hospital Universitário de Brasília, Brasília, and others)

Chapter 4
Wound Healing and Skin Care in Inherited Epidermolysis Bullosa
(Yordanova Ivelina, Vassileva Snejina, Gospodinov Dimitar, Department of Dermatology and Venereology, Medical University Pleven, Bulgaria, and others)

Chapter 5
Strategies Integrating Gene Therapy and Tissue Engineering into the Development of Treatments for Recessive Dystrophic Epidermolysis Bullosa
(Angela Dakiw Piaceski, Danielle Larouche, Francis Bisson, Karim Ghani, Manuel Caruso, Lucie Germain, Centre de Recherche en organogénèse expérimentale de l’Université Laval/LOEX, Canada, and others)

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