Enhancement of Human Cancer Cell Radiosensitivity by Conjugated Eicosapentaenoic Acid, an Inhibitor of DNA Polymerase and Topoisomerase


Yoshiyuki Mizushina, Yuko Kumamoto-Yonezawa and Hiromi Yoshida
Kobe-Gakuin University, Japan

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

DNA topoisomerases (topos) and DNA polymerases (pols) are involved in many aspects of DNA metabolism such as DNA replication and repair. This book aims to assess the relative inhibitory effects of conjugated and normal fatty acids, and to assess the efficacy of the combined treatment of fatty acids and X-ray radiation on human cancer cells. (Imprint: Nova)



Table of Contents


1. Introduction

2. Preparation of Conjugated Pufas

3. Mammaliam Pol alpha and beta Inhibition by Normal and Conjugated Pufas

4. Human Topo Inhibition by Normal and Conjugated Pufas

5. Effect of Normal and Conjugated Pufas on Various Pols and Dna Metabolic Enzymes

6. Influence of Cepa on the Hyperchromicity of dsDNA

7. Effect of cEPA on Inhibition of Human Cancer Cell Growth

8. Effect of cEPA on Expression of Pols in HCT116 Cells

9. Inhibitory Effect of cEPA on the Repair Activity of DNA Damaged by X-Ray Radiation

10. Effect of cEPA on HCT116 Cell Radiosensitivity

11. Effect of cEPA on Enhancement of Radiation-Induced Apoptosis

12. Discussion




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