Endothelial Dysfunction: Risk Factors, Role in Cardiovascular Diseases and Therapeutic Approaches


Trent H. Keaton (Editor)

Series: Cardiology Research and Clinical Developments
BISAC: MED010000

The endothelium is a thin mono-cellular layer which covers the inner surface of the blood vessels, separating the circulating blood from the tissues and also has the responsibility for uninterrupted maintenance of circulation to all the vital tissues. Endothelium is a very active organ, it works as a receptor-effector organ and responds to each physical or chemical stimulus with the release of the appropriate substance with which it may maintain vasomotor balance and vascular-tissue homeostasis. It has the property of producing, independently, both agonistic and antagonistic substances that help to keep homeostasis and its function is not only autocrine, but also paracrine and endocrine. In this way it modulates the vascular smooth muscle cells producing relaxation or contraction, and therefore vasodilatation or vasoconstriction.

The vascular endothelium is vulnerable to maximum wear and tear due to its positioning and requires prompt regeneration of the cells. Whenever the imbalance between substances with vasodilating, antimitogenic, and antithrombogenic properties and substances with vasoconstricting, prothrombotic and proliferative characteristics takes place, it causes a pathological condition known as endothelial dysfunction. These substances intervenes in cell proliferation and migration, in leukocyte adhesion and activation and in immunological and inflammatory processes, further which is responsible for apoptosis of vascular endothelial cells resulting in overall endothelial dysfunction and vasculopathy. This book discusses, in further detail, the risk factors, and the role of endothelial dysfunction in cardiovascular diseases and therapeutic approaches to dealing with endothelial dysfunction. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1 – Effects of Cancer Therapies on Vascular Structure and Function in Childhood Cancer Survivors (pp. 1-26)
Kara L. Marlatt and Donald R. Dengel (Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA, and others)

Chapter 2 – Endothelial Dysfunction in Acute Lung Injury (pp. 27-50)
Saurabh Aggarwal, Christine M. Gross and Stephen M. Black (Georgia Regents University, Vascular Biology Center, Augusta, Georgia, USA, and others)

Chapter 3 – Endothelial Function and Cardiovascular Disease: Role of Exercise Training (pp. 51-68)
Fernando Ribeiro, Nórton Luís Oliveira, Alberto Jorge Alves and José Oliveira (School of Health Sciences, University of Aveiro, Agras do Crasto – Campus Universitário de Santiago, Aveiro, Portugal, and others)

Chapter 4 – Endothelial Vascular Function in Heart Transplant and Advanced Heart Failure Therapies (pp. 69-84)
Enrique Gutiérrez Ibañes, Pablo Díez Villanueva, Jesús Palomo Álvarez, Jaime Elízaga Corrales and Francisco Fernández-Avilés (Department of Cardiology. Instituto de Investigación Sanitaria Gregorio Marañón. Departamento de Medicina, Universidad Complutense de Madrid. Hospital Gregorio Marañón, Madrid, Spain)

Chapter 5 – Inner Ear Endothelial Dysfunction due to Oxidative Stress: A Possible Role in the Pathogenesis of Sensorineural Hearing Loss (pp. 85-90)
Andrea Ciorba, Laura Crema, Francesco Maldotti and Chiara Bianchini (ENT and Audiology Department, University Hospital of Ferrara, Italy)

Chapter 6 – Novel Risk Factors and Vascular Endothelium (pp. 91-112)
Dimitris Tousoulis, Emmanuel Androulakis, Spyridon Papaioannou, Nikolaos Papageorgiou and Christodoulos Stefanadi (1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece)

Chapter 7 – Role of Neutrophils in Development of Endothelial Dysfunction at Coronary Heart Disease (pp. 113-122)
Andrey Eu. Kratnov (Yaroslavl State Medical Academy, Yaroslavl, Russia)

Chapter 8 – Endothelial Dysfunction in Diabetes and Impact of Therapeutic Approaches (pp. 123-168)
Manish Mishra, Ananda Kumar and Amit Nandan Dhar Dwivedi (All Saints University, College of Medicine, Kingstown, St. Vincent and the Grenadines, and others)

Chapter 9 – Attenuation of eNOS-NO Biosynthesis, Up-Regulation of Antioxidant Proteins and Differential Protein Regulation in TNF-Alpha Treated Cardiac Endothelial Cells: Early Signs of Endothelial Dysfunction (pp. 169-204)
Amanda Genis, Salomé Smit, Corli Westcott, Mashudu Mthethwa and Hans Strijdom (Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa, and others)

Chapter 10 – Endothelial Dysfunction and Cardiovascular Risk in Patients with End-Stage Renal Disease (pp. 205-228)
Senija Rasic, Damir Rebic, Jasminka Dzemidzic and Snezana Uncanin (Clinic for Nephrology, Clinical Center of Sarajevo University Bolnicka, Sarajevo, Bosnia and Herzegovina)

Chapter 11 – Attachment Styles, Endothelial Biomarkers Dysfunction and Increased Cardiovascular Disease Risk in Elderly Individuals (pp. 229-246)
Daniel Serrani Azcurra


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