Endoplasmic Reticulum Stress: Regulation, Function and Role in Health and Disease


Cameron Wagner (Editor)

Series: Cell Biology Research Progress
BISAC: SCI017000

This book provides current research on the regulation, function and role in health and disease of endoplasmic reticulum (ER) stress. The first chapter focuses on evidence that supports the role of endoplasmic reticulum stress, mitochondria-associated membranes (MAMs) microdomain and oxidative stress during obesity as a molecular pathway to type 2 diabetes mellitus (T2DM) development. Also, it addresses protein missfolding and mitochondria function as potential targets to improve metabolic derangements in obesity and T2DM. Chapter Two summarizes and discusses the current understanding of molecular mechanisms linking ER stress to beta cell fate. Chapter Three depicts the association between eIF2á kinase-linked pathways and diet-linked pathogenic responses (such as ones caused by microbes or nutritional abnormalities). Chapter Four reviews placental endoplasmic reticulum stress in the determination of pregnancy outcome. The last chapter discusses the role of ER stress in meditating the anticancer effects of tocotrienols. (Imprint: Nova Biomedical)


Table of Contents

Table of Contents


Chapter 1. Potential Role of Endoplasmic Reticulum Stress Activation in Obesity and Type 2 Diabetes Pathophysiology
Robbi Elizabeth Cardenas-Perez, Lizeth Fuentes-Mera and Alberto Camacho (Biochemistry Department, Faculty of Medicine, Neuroscience Unit, Gene Therapy Unit, Center for Research and Development in Health Sciences, Autonomous University of Nuevo Leon, Mexico)

Chapter 2. Signaling Pathways Promoting Beta Cell Survival under ER Stress: Role of Sphingosine 1-Phosphate and Cellular Inhibitor of Apoptosis Protein-1
Ziyu Song, Wei Wang and Pu Xia (Fudan Institute for Metabolic Diseases and Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China, and others)

Chapter 3. Diet-derived Integrated Stress Responses, eIF2á kinase, and Related Diseases
Yuseok Moon (Laboratory of Mucosal Exposome and Biomodulation, Department of Biomedical Sceinces, Pusan National University, Yangsan, South Korea, and others)

Chapter 4. Placental Endoplasmic Reticulum Stress in the Determination of Pregnancy Outcome: From Homeostasis to Pathophysiology
Hong Wa Yung and Graham J. Burton (Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom)

Chapter 5. Role of Endoplasmic Reticulum Stress in Mediating the Anticancer Effects of Tocotrienols
Osama A. Alawin, Rayan A. Ahmed, Venkateswararao Dronamraju, Ibrahim G. Algayadh, Amr A. Kalloub and Paul W. Sylvester (School of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA)



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