Endometrial Cancer: Current Epidemiology, Detection and Management (Second Edition)


Samir A. Farghaly, M.D., PhD – Professor, New York Presbyterian Hospital, Cornell University Medical Center, Cornell University, New York, NY, USA

Series: Obstetrics and Gynecology Advances
BISAC: MED033000; MED062000
DOI: 10.52305/XDFN1391

The purpose of this book is to provide a broad background of several aspects of basic sciences, clinical, therapeutic aspects, and management of endometrial cancer. It provides state-of-the-art information on the molecular genetics, biology, and clinical aspects of premalignant lesions of the endometrium and endometrial cancer. Also, the book chapters provide better understanding of the molecular and cellular events that underlie endometrial cancer. The descriptive and analytical epidemiology of endometrial cancer are presented in Chapter 1. The pathology and molecular diagnosis of endometrial cancer are discussed in Chapter 2. The molecular pathology of endometrial cancer is detailed in Chapter 3. The hereditary aspect of endometrial cancer is highlighted in Chapter 4. Precancerous lesions of the endometrium are reviewed in detail in Chapter 5. Endometrial biomarkers are detailed in Chapter 6. Lymphatic mapping of endometrial cancer is discussed in Chapter 7. Sentinel lymph nodes in endometrial cancer are highlighted in Chapter 8. The current strategies and approaches to treat patients with endometrial cancer are detailed in Chapter 9. Surgical techniques for endometrial cancer are reviewed in Chapter 10. The current treatment of advanced endometrial cancer is discussed in Chapter 11. Adjuvant medical therapeutic modalities are reviewed in Chapter 12. Targeted therapies for advanced endometrial cancer are presented in Chapter 13. The role of ErbB targeted therapy in treating endometrial cancer is discussed in Chapter 14. Finally, the quality of life of women with endometrial cancer is reviewed in Chapter 15. This book is intended for all clinicians and basic medical scientists caring for women with endometrial cancer, including attending surgeons and physicians, clinical fellows, and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology, as well as PhD students and post-doctoral fellows in the basic medical sciences.

Table of Contents


Chapter 1. Descriptive Epidemiology and Etiology of Endometrial Cancer
Anjum Memon¹, Peter Bannister¹,², Samantha Edensor¹, Mais Tattan¹, Imogen Rogers¹ and Sonali Kaushik²
¹Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, UK
²Royal Sussex County Hospital, Brighton, UK

Chapter 2. Pathology and Molecular Diagnosis of Endometrial Tumors
Jesse L Hart¹,², DO, Mariana Canepa¹,³, MD and Maria Luisa Garcia-Moliner¹, MD
¹Warren Alpert Medical School, Brown University, Providence, RI, USA
²Lifespan Academic Medical Center, Providence, RI, USA
³Lifespan Academic Medical Center, Providence, RI, USA

Chapter 3. Molecular Pathology of Endometrial Carcinomas
Bharat Rekhi, MD, DNB, MIAC and Santosh Menon, MD, DNB
Department of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI) University, Mumbai, Maharashtra, India

Chapter 4. Hereditary Endometrial Cancer
Angela George¹,², MB, ChB, MD, FRACP
¹Gynaecology Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
²Cancer Genetics Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom

Chapter 5. Endometrial Cancer Precursors
Luca Mencaglia, Claudia Tosti, Stefania Magnolfi and Francesca Ciociola
U.O.C. PMA Fisiopatologia della Riproduzione Umana, Cortona, Italy
Dipartimento Materno Infantile, Azienda USL Toscana SUD EST, Italy

Chapter 6. Endometrial Cancer Biomarkers
Hajar Ku Yasin¹, Anthony Henry Taylor² and Thangesweran Ayakannu³,⁴
¹Department of Obstetrics and Gynaecology, Cumberland Infirmary, Carlisle, UK
²Departments of Medical and Social Care Education and Molecular and Cell Biology, University of Leicester, Leicester, UK
³Gynaecology Oncology Cancer Centre, Liverpool Women’s NHS Foundation Trust, Liverpool Women’s Hospital, Liverpool, UK
⁴Sunway Medical Centre, Bandar Sunway, Petaling Jaya, Selangor, Malaysia

Chapter 7. Lymphatic Mapping for Endometrial Cancer
Valerio Mais, Maria Luisa Fais, Valentina Locati, Giulia Carboni and Michele Peiretti
Division of Maternal-Fetal Medicine, Department of Surgical Sciences, University of Cagliari Medical School, Italy

Chapter 8. Sentinel Lymph Nodes in Endometrial Cancer
Helena Robova and Lukas Rob
Department of Obstetrics and Gynaecology, Charles University in Prague, Czech Republic

Chapter 9. Current Approaches for Treating Female Patients with Endometrial Cancer
Samir A. Farghaly, MD, PhD
The Joan and Sanford I. Weill Medical College/The Graduate School of Medical Sciences, and the New York- Presbyterian Hospital/Weill Cornell Medical Center, Cornell University, New York, NY, USA

Chapter 10. Surgical Procedures for Treating Patients with Endometrial Cancer
Samir A. Farghaly, MD, PhD
The Joan and Sanford I. Weill Medical College, The Graduate School of Medical Sciences, and The New York-Presbyterian Hospital, Weill Cornell Medical Center, Cornell University, New York, NY, US

Chapter 11. Treatment of Advanced Stage Endometrial Cancer
Ai Miyoshi, MD, Yutaka Ueda and Tadashi Kimura
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan

Chapter 12. Adjuvant Therapy in Endometrial Cancer
T. Sivakumaran¹, P. Khaw¹ and L. Mileshkin¹,²
¹Peter MacCallum Cancer Centre, Melbourne, Australia.
²Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia

Chapter 13. Targeted Therapies for Endometrial Cancer
Selen Dogan¹, Nasuh Utku Dogan¹ and Kubra Boynukalin²
¹Akdeniz University, Department of Gynecology, Antalya
²Bahceci Clinic, İstanbul, Turkey

Chapter 14. Is It Time to Reconsider the Clinical Role of ErbB Targeted Therapy in Endometrial Cancer?
Georgios Androutsopoulos, Ioanna Styliara, Evgenia Zarogianni, Georgios Michail, Georgios Adonakis
Gynaecological Oncology Unit, Department of Obstetrics and Gynaecology, University of Patras, Medical School, Rion, Greece

Chapter 15. Quality of Life in Women with Endometrial Cancer
Claudia Rutherford¹, Rebecca Mercieca-Bebber¹,², Margaret-Ann Tait¹, Lisa Sullivan³, Linda Mileshkin⁴ and Madeleine T. King¹
¹University of Sydney, Faculty of Science, School of Psychology, Sydney, New South Wales, Australia
²University of Sydney, Sydney Medical School, Central Clinical School, Sydney, NSW, Australia
³The Canberra Hospital, Canberra, ACT, Australia
⁴Peter MacCallum Cancer Centre, Melbourne, VIC, Australia


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