Endometrial Cancer: A Comprehensive Clinical and Translational Update

Ivan Diaz-Padilla and Jesus Garcia-Donas (Editors)
Gynecologic Cancer Program Division of Medical Oncology, Centro Integral Oncologico, Clara Campal University Hospital, HM Madrid, Spain

Series: Cancer Etiology, Diagnosis and Treatments, Women’s Issues
BISAC: MED062000

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Endometrial cancer is the most common gynecological malignancy in women in developed countries. Most cases are generally diagnosed at an early-stage and curable with loco-regional therapies. Metastatic and/or recurrent disease still remains a therapeutic challenge and clearly represents an unmet medical need. Substantial progress has been made over the last decade in different fields of gynecologic oncology that has translated into a better understanding of the biology and clinical behavior of endometrial cancer and its management.

Hence, this monograph provides a current overview of endometrial cancer spanning from its clinical epidemiology to molecular cancer therapeutics. The most relevant clinical aspects such as imaging, new surgical and radiation techniques and the role of endocrine therapy and chemotherapy in the systemic treatment of endometrial cancer will also be discussed. With the contributions of internationally well-renowned experts in the field, this book will keep the reader abreast of the most recent advances in endometrial cancer from a multi-disciplinary perspective. This monograph is highly recommended for OB/GYN residents and fellows, nurse practitioners, junior faculty and all those interested in the field of women’s cancer. (Imprint: Nova Biomedical )

Chapter 1 - The Epidemiology of Endometrial Cancer (pp. 1-30)
Stephanie Irene Ayre and Laurie Elit (Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada)

Chapter 2 - Inherited Predisposition to Endometrial Cancer (pp. 31-58)
Ignacio Romero Noguera and Zaida García-Casado (Clinical Area Gynecologic Oncology, Instituto Valenciano de Oncologia, Valencia, and Laboratory of Molecular Biology, Instituto Valenciano de Oncologia, Valencia, Spain)

Chapter 3 - Endometrial Carcinoma: Pathological and Molecular Features (pp. 59-82)
Xavier Matias-Guiu (Department of Pathology and Molecular Hospital Universitari Arnau de Vilanova, University of Lleida, Institute of Biomedical Research in Lleida-IRBLLEIDA)

Chapter 4 - Imaging Techniques for Staging of Endometrial Carcinoma (pp. 83-116)
Manjiri Dighe and Neeraj Lalwani (University of Washington Medical Center, Department of Radiology, WA, US)

Chapter 5 - New Surgical Approaches to Early-Stage Endometrial Cancer (pp. 117-146)
Stefano Palomba, Vincenzo Dario Mandato and Giovanni Battista La Sala (Academic Department of Obstetrics & Gynecology, Arcispedale S. Maria Nuova of Reggio Emilia, IRCCS, University of Modena & Reggio Emilia)

Chapter 6 - Radiation Therapy in Early-Stage Endometrial Cancer (pp. 147-156)
Millie Light and Melanie Powell (Specialist Registrar in Clinical Oncology, University College Hospital, London, and Consultant Clinical Oncologist and Honorary Senior Clinical Lecturer, St. Barthololmew’s Hospital, London, UK)

Chapter 7 - The Role of Adjuvant Chemotherapy in Endometrial Cancer (pp. 157-176)
Thomas Hogberg (Associate Professor, Department of Cancer Epidemiology, University of Lund, University Hospital, SE-221 85 Lund, Sweden)

Chapter 8 - Systemic Chemotherapy: Endometrial Cancer (pp. 177-184)
John A. Green (Institute of Translational Medicine, University of Liverpool, UK)

Chapter 9 - Molecular Targeted Therapies in Endometrial Cancer: Current Concepts and Future Challenges (pp. 185-214)
Shannon N. Westin and Russell R. Broaddus (Departments of Gynecologic Oncology and Pathology, University of Texas M. D. Anderson Cancer Center, Houston, TX, US)

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