Table of Contents

Table of Contents

Preface

Neuroplasticity: A New Approach to Treatment of Depression
(I. Tayfun Uzbay)

Antidepressants Therapy and Risk of Suicide among Patients with Major Depressive Disorders
(Maurizio Pompili, Gianluca Serafini, Marco Innamorati, Antonio Del Casale, Michele Battuello, Mariantonietta Milelli and Roberto Tatarelli)

Monitoring of Antidepressant Therapy by Using Heart Rate Variability
(Sven Suefke, Hasib Djonlagic, and Thomas Kibbel)

The Overlap between Depression and Suicidal Behaviour: Implication for the Preventative Effect of Antidepressant Pharmacotherapy
(Louise Brådvik and Mats Berglund)

Synthetic Inhibitors of Prolyl Endopeptidase Exhibit Antidepressant-Like Effects in Rat Models of Depressive Syndrome and Anxiety-Depression State
(N.A. Krupina , N.N. Khlebnikova, N.N. Zolotov, E.Yu Kushnareva, N.G. Bogdanova, and I.N. Orlova)

Beyond the Monoamine Hypothesis: The Quest for an Integrative Aetiology of Depression and New Therapeutic Strategies
(Barbara Di Benedetto, Rainer Rupprecht, and Gerhard Rammes)

Tianeptine and sertraline: underlying neurochemical mechanisms of action
(Rustem Uzbekov and Irina Alieva)

Gender Differences in Response to Antidepressants
(Shigeru Morishita, Toshihiko Kinoshita and Seizaburo Arita)

Expert Commentary: Adult Neurogenesis and Depression: A Novel Theory for Depression?
(Philippe Taupin)

Micro- and Nano-Particulate Drug Delivery Systems for Cancer Treatment
(Jose L. Arias – Dept. of Pharmacy and Pharmaceutical Technology, Univ. of Granada, Granada, Spain)

Geldanamycin Derivatives as Promising Anticancer Drugs: Therapy via Hsp90 Inhibition
(Alexander E. Kabakov – Dept. of Radiation Biochemistry, Medical Radiology Research Center, Obninsk, Russia)

Synergistic Antitumor Activity of Metronomic Dosing Chemotherapy in Combination with Liposomal Anticancer Drug
(Tatsuhiro Ishida, Hiroshi Kiwada – Dept. of Pharmacokinetics and Biopharmaceutics, Univ. of Tokushima, Sho-machi, Tokushima, Japan)

Organotin Polyethers as Anticancer Drugs
(Charles E. Carraher, Jr., Michael R. Roner, Girish Barot – Florida Atlantic Univ., Dept. of Chemistry and Biochemistry, Boca Raton, FL and others)

Studies on Anticancer Agents: Phenolic Compounds and their Pharmacological Activity
(Maria Dolors Pujol, Isabel Sanchez – Laboratori de Quimica Farmaceutica, Univ. de Barcelona, Barcelona, Spain)

Design of Novel Anticancer Drugs Utilizing Busulfan for Optimizing Pharmacological Properties and Pattern Recognition Techniques for Elucidation of Clinical Efficacy
(Ronald Bartzatt – Univ. of Nebraska, Chemistry Department, Omaha, NE, USA)

Analysis of Associations Among Novel Property Descriptors and their Capacity in Determining Clinical Efficacy by Utilizing Pattern Recognition Technigues
(Ronald Bartzatt – Univ. of Nebraska, Chemistry Department, Omaha, NE, USA)

Insights into the Mode of Action of Investigational Ruthenium(III) Cytotoxins from Electrochemical and Biological Studies
Erwin Reisner – Univ. of Oxford, Inorganic Chemistry Laboratory, Oxford, UK)

Marina Crystal Minerals(MCM) Induce Apoptosis of Human Metastatic Breast Cancer MDA-MB-231 Cells In Vitro
(Mamdooh Ghoneum, Takeshi Ogura, Sastry Gollapudi- Dept. of Otolaryngology, Drew Univ. of Medicine and Science, Los Angeles, CA, USA and others)

Bioequivalence: Some Relevant Clinical and Biopharmaceutic Aspects
(Francisco J. Flores-Murrieta, Miriam del C. Carrasco-Portugal, Héctor León-Molina and Miguel Luján, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, México, D.F., México)

Advances in Drug Discovery to Assess Cholinergic Neurotransmission
(David R. da Rocha, Vitor F. Ferreira, Kátia G. Lima Araújo, Wilson C. Santos, Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil, and others)

Method Suitability for Models of Intestinal Drug Permeability
(Donna A. Volpe, Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD)

Stevens-Johnson Syndrome with Ocular Complication
(Mayumi Ueta, Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan, Research Center for Regenerative Medicine, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan)

Prophylactic Effect of Rescalmin, an Antiallergic Agent, Against Hypersensitivity Reactions to Anticancer Drugs: Paclitaxel and Beyond
(Shinji Sasada, Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Osaka, Japan)

Pharmacopoeial Quality of Antimicrobial and Antiviral Formulations from Former Soviet Union Republics: Focus on Aciclovir
(Andres Meos and Vallo Matto, Institute of Pharmacy, University of Tartu, Estonia)

The Interaction of the Prion Protein with Triazine-based Biomimetic Affinity Ligands
(Giannis Mavridis and Nikolaos E. Labrou, Laboratory of Enzyme Technology, Department of Agricultural Biotechnology, Agricultural University of Athens, Athens, Greece)

Downstream Processing Strategies for the Purification of Recombinant Proteins from Transgenic Maize. Chromatographic Evaluation of the Synthetic Affinity Ligand 4-Amino-phenyl-oxanilic acid
(Dimitris Platis and Nikolaos E. Labrou, Laboratory of Enzyme Technology, Department of Agricultural Biotechnology,
Agricultural University of Athens, Athens, Greece)

A Critical Approach to an Allergic Paradox: Allergic and Allergic-Like Reactions to Glucocorticoids: Delayed Hypersensitivity Mechanisms
(M.T. Ventura, R. Buquicchio, G.F. Calogiuri, Department of Internal Medicine, Immunology and Infectious Diseases (MIDIM), University of Bari Medical School, Italy, and others)

Index