Encyclopedia of Genetics: New Research (8 Volume Set)


Heidi Carlson (Editor)

Series: Genetics – Research and Issues
BISAC: SCI029000

This 8 volume encyclopedia set presents important research on genetics. Some of the topics discussed herein include the speciation of Arabian gazelles, tau alternative splicing in Alzheimer’s disease, Cornelia de Lange syndrome and autosomal dominant polycystic kidney disease. (Imprint: Nova)


Table of Contents

Table of Contents


Volume 1

Chapter 1. Speciation in Diatoms: Patterns, Mechanisms, and Environmental Change
(Joshua T. Cooper and John P. Masly, Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, US, and others)

Chapter 2. Speciation of Island Plants: The Natural Laboratory of Lord Howe Island
(Alexander S. T. Papadopulos, William J. Baker and Vincent Savolainen, Imperial College London, Silwood Park Campus, Ascot, Berkshire, UK, and others)

Chapter 3. Speciation of Arabian Gazelles
(Hannes Lerp, Torsten Wronski, Thomas M. Butynski and Martin Plath, Evolutionary Ecology Group, J.W. Goethe–University Frankfurt, Frankfurt am Main, Germany, and others)

Chapter 4. Chromosome Plasticity, Adaptation and Speciation in Malaria Mosquitoes
(Igor V. Sharakhov, Department of Entomology, Fralin Life Science Institute, Virginia Tech, Blacksburg, VA, US)

Chapter 5. Transcriptional Differentiation Across the Four Subspecies of Drosophila mojavensis
(Luciano M. Matzkin and Therese A. Markow, Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL, US, and others)

Chapter 6. Evolution of Male Courtship Songs in the Drosophila buzzatii Species Cluster
(Cássia C. Oliveira, Maura H. Manfrin, Fábio de M. Sene and William J. Etges, Program in Ecology and Evolutionary Biology, Department of Biological Sciences, University of Arkansas,
Fayetteville, AR, US, and others)

Chapter 7. Prezygotic Isolation in the Parasitoid Wasp Genus Nasonia
(Maartje C. W. G. Giesbers, Sylvia Gerritsma, Jan Buellesbach, Wenwen Diao, Bart A. Pannebakker, Louis van de Zande, Thomas Schmitt and Leo W. Beukeboom, Evolutionary Genetics, Center for Ecological and Evolutionary Studies, University of Groningen, Netherlands, and others)

Chapter 8. Where to Look for Speciation Genes When Divergence is Driven by Postmating, Prezygotic Isolation
(Jeremy L. Marshall, Department of Entomology, Kansas State University, Manhattan,

Chapter 9. The Molecular and Evolutionary Basis of Hybrid Sterility: From Odysseus to Overdrive
(Nitin Phadnis and Harmit S. Malik, Department of Biology, University of Utah, Salt Lake City, UT, US, and others)

Chapter 10. The Role of Transposable Elements in Speciation
(Eric T. Watson and Jeffery P. Demuth, Department of Biology, University of Texas at Arlington, Arlington, TX, US)

Chapter 11. Hybrid Incompatibility: Are Cellular Processes the Battlefields of Genomic Conflict?
(Norman A. Johnson, Department of Biology, Department of Environmental Conservation,
Graduate Program in Organismal and Evolutionary Biology, University of Massachusetts, Amherst MA, US)

Chapter 12. Processes in Organic and Cultural Evolution
(Börje Ekstig, Department of Education, Uppsala University, Uppsala, Sweden)

Chapter 13. Natural Selection and Diabetes Mellitus
(Svetlana Shtandel, V. Danilevsky Institute for Endocrine Pathology Problems, Kharkov, Ukraine)

Chapter 14. Genetic Drift Among Native People from South American Gran Chaco Region Affects Interleukin 1 Receptor Antagonist Variation
(Cecilia Inés Catanesi and Laura Angela Glesmann, Laboratory of Genetic Diversity, IMBICE, La Plata, Argentine)

Volume 2

Chapter 15. Alternative Splicing and Neurological Disorders: Focus on Parkinson’s Disease
(Sebastiano Cavallaro, Department of Biomedical and Biotechnological Sciences, Section of Human Anatomy and Histology, University of Catania, Italy, and others)

Chapter 16. Tau Alternative Splicing in Alzheimer’s Disease
(Gonzalo Emiliano Aranda-Abreu, María Elena Hernández Aguilar, Fausto Rojas Durán, Sonia Lilia Mestizo Gutiérrez and Jorge Manzo Denes, Universidad Veracruzana/Centro de Investigaciones Cerebrales, Xalapa Veracruz, Mexico)

Chapter 17. The Role of Splicing Factors in Cancer Prognosis and Treatment
(Rebeca Martínez-Contreras and Nancy Martínez-Montiel, Molecular and Microbial Ecology Lab, Center of Research on Microbiological Sciences, Science Institute, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico)

Chapter 18. Nonsense-Mediated Decay and Human Disease
(Nancy Martínez-Montiel and Rebeca Martínez-Contreras, Molecular and Microbial Ecology Lab, Center of Research on Microbiological Sciences, Science Institute, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico)

Chapter 19. Alternative Splicing Alterations in Alzheimer’s Disease
(T. A. Ishunina and D.F. Swaab, Department of Histology, Embryology, Cytology, Kursk State Medical University, Kursk, Russia, and others)

Chapter 20. Plant RNA-Binding Proteins Implicate mRNA Processing in Abscisic Acid (ABA) Responses
(Raquel F. Carvalho, Vera S. Nunes and Paula Duque, Instituto Gulbenkian de Ciência, Portugal)

Chapter 21. Comprehensive Analyses of Alternative Exons in Neuronally Differentiated P19 Cells
(Hitoshi Suzuki and Toshifumi Tsukahara, School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan)

Chapter 22. Identification of Genuine Alternative Splicing Variants for Rare or Long-Sized Transcripts
(Seishi Kato, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan)

Chapter 23. An Epigenetic View on Alternative Splicing
(Gabriele A. Fontana, Aurora Rigamonti and Silvia M. L. Barabino, Department of Biotechnology and Biosciences, University of Milano-Bicocca Piazza della Scienza, Milan, Italy)

Chapter 24. Alternative RNA Splicing and Regulation of Nitric Oxide Signaling
(Iraida G. Sharina, Department of Internal Medicine, Division of Cardiology, University of Texas Medical School, Houston, TX, US)

Chapter 25. Alternative Splicing by Analyzing a Human mRNA Diversity Using Data of FLJ Human cDNAS
(Takao Isogai and Ai Wakamatsu, Fukushima Medical University, Hikarigaoka, Fukushima, Japan, and others)

Chapter 26. Alternative Splicing in Human Immune System and Autoimmune Diseases
(Xiang Guo, Translational Sciences, MedImmune, LLC, Gaithersburg, MD, US)

Chapter 27. Poly(ADP-Ribosyl)ation Regulates Alternative Splicing
(Yingbiao Ji and Alexei V. Tulin, Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, US)

Chapter 28. Patent Roadmap for the Biosensor Space
(Mohamed C. Azeez, Unisha Patel and Dennis S. Fernandez, Fernandez & Associates, LLP, Atherton, CA, US)

Chapter 29. Avoidant/Restrictive Food Intake Disorder in a Female Patient Affected by Marfan Syndrome
(Verri A. P., Serio A., Grasso M., Brega I. and Clerici F., Centre for Inherited Cardiovascular Diseases, IRCCS, Fondazione Policlinico San Matteo, Pavia, Italy)

Chapter 30. Optimizing Oil Production in B. napus by Gene Stacking: Transgenic Co-expression of DGAT1 and Partially-Suppressed mtPDCK Cumulatively Enhance Seed Lipid Deposition
(Elizabeth-France Marillia, Tammy Francis and David C. Taylor, National Research Council of Canada, Saskatoon, Saskatchewan, Canada)

Chapter 31. Periodontitis: A Common Oral Disease the Genetic Susceptibility
(Ying Zheng, You-Qiang Song and W. Keung Leung, Faculty of Dentistry and 2Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China)

Chapter 32. Genomic Imprinting and the Brain: Neuron-Specific Switching of Gene Expression at Imprinting Regions
(Masamitsu Eitoku and Hidenori Kiyosawa, Department of Environmental Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan)

Chapter 33. Pharmacogenomics Focusing on Phase Two Metabolizing Enzymes
(Kung-Hao Liang, Chang Gung Memorial Hospital, Taiwan)

Volume 3

Chapter 34. Sexual Dimorphism in Insect Longevity: Insights from Experimental Evolution
(Jelica Lazarević, Biljana Stojković and Nikola Tucić, Institute for Biological Research, University of Belgrade, Serbia, and others)

Chapter 35. Evidence of Natural and Sexual Selection Shaping the Size of Nuptial Gifts among a Single Bush-Cricket Genus (Poecilimon; Tettigoniidae): An Analysis of Sperm Transfer Patterns
(J. McCartney, M. A. Potter, A. W. Robertson, K-G. Heller and D. T. Gwynne, Ecology Group, Institute of Agriculture and Environment, Massey University, Palmerston North, New Zealand, and others)

Chapter 36. Mate Choice Copying in Both Sexes of the Guppy: The Role of Sperm Competition Risk and Sexual Harassment
(Claudia Zimmer, Alexandros S. Gavalas, Benjamin Kunkel, Janina Hanisch, Sara Martin,
Svenja Bischoff, Martin Plath and David Bierbach, Department of Ecology and Evolution, University of Frankfurt, Frankfurt am Main, Germany, and others)

Chapter 37. Sexual Selection under Parental Choice: Mating Strategies and Reproductive Success
(Menelaos Apostolou and Marianna Zacharia, University of Nicosia, Nicosia, Cyprus)

Chapter 38. Melon Germplasm Characteristics, Diversity, Preservation and Uses
(C. Mallor and A. Díaz, Unidad de Hortofruticultura, Instituto Agroalimentario de Aragón (IA2) (CITA-Universidad de Zaragoza), Zaragoza, Spain)

Chapter 39. Preservation and Characterization of Woodland Grape (Vitis vinifera ssp. sylvestris GMEL.) Genotypes of the Szigetköz, Hungary
(Gizella Jahnke, Zóra Annamária Nagy, Gábor Koltai, Edit Hajdu and János Májer, National Agricultural Research and Innovation Centre, Research Institute for Viticulture and Enology, Research Station of Badacsony, Badacsonytomaj, Hungary, and others)

Chapter 40. A Mini Review on Morphological and Genetic Diversity of Sweet (Prunus avium L.) and Sour Cherry (Prunus cerasus L.) Cultivars
(Ioannis Ganopoulos, Panagiotis Madesis, Filippos A. Aravanopoulos, Athanasios Tsaftaris,
Thomas Sotiropoulos and Konstantinos Kazantzis, Institute of Applied Biosciences, CERTH, Thermi, Thessaloniki, Greece, and others)

Chapter 41. Research on Purple Seed Stain of Soybean: Germplasm Screening and Genetic Resistance
(Shuxian Li, Pengyin Chen, Bo Zhang and Grover Shannon, United States Department of Agriculture-Agricultural Research Service, Crop Genetics Research Unit, Stoneville, MS, US, and others)

Chapter 42. Somatic and Gonadal Tissue Cryopreservation – An Alternative Tool for The Germplasm Conservation in Wild Mammals
(Alexsandra Fernandes Pereira, Alexandre Rodrigues Silva, Gabriela Liberalino Lima and Andréia Maria da Silva, Laboratory of Animal Germplasm Conservation, Federal Rural University of Semi-Arid, Mossoró, RN, Brazil)

Chapter 43. Mitochondrial Gene Diversity of the Mega-Herbivorous Species of the Genus Tapirus (Tapiridae, Perissodactyla) in South America and Some Insights on Their Genetic Conservation, Systematics and the Pleistocene Influence on Their Genetic Characteristics
(Manuel Ruiz-García, Armando Castellanos, Luz Agueda Bernal, Diego Navas, Myreya Pinedo-Castro1 and Joseph Mark Shostell, Laboratorio de Genética de Poblaciones-Biología Evolutiva, Unidad de Genética. Departamento de Biología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá DC, Colombia, and others)

Chapter 44. Strategies for Gene Prospecting of Plants in Response to Drought and Salinity
(Deyvid Novaes Marques, Nicolle Louise Ferreira Barros, Diehgo Tuloza da Silva, Fabiano Melo de Brito and Claudia Regina Batista de Souza, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil, and others)

Chapter 45. Clinical Evidence and the Genetic Effects of Traditional Chinese Medicine for the Management of Proteinuria in Patients with Diabetic Nephropathy
(Xiang Tu, XueFeng Ye, Quan Hu, ChunGuang Xie, ChengShi He, Ming Chen, James B. Jordan and Sen Zhong, National Traditional Chinese Medicine Clinical Research Base for Diabetes Mellitus/Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China, and others)

Chapter 46. Biochemistry and Genetics of Ansamycin Antibiotics
(Amit Kumar Jha and Jae Kyung Sohng, Department of BT-Convergent Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, Kalsan-ri, Tangjeong-myeon, Asan-si, Chungnam, Republic of Korea)

Chapter 47. BRCA Gene Mutations Mediate Particularly High TNBC Risk by Defective Estrogen Signaling
(Zsuzsanna Suba, National Institute of Oncology, Surgical and Molecular Tumor Pathology Centre, Budapest, Hungary)

Chapter 48. Genotype-Phenotype Relationships in Language Processes in Rett Syndrome
(Alessandra Falzone, Antonio Gangemi and Rosa Angela Fabio, Department of Cognitive Science, University of Messina, Italy)

Chapter 49. Marfan Syndrome: A Rare and Sometime Very Disabling Genetic Disorder
(Henry J. Mankin and Keith P. Mankin, Massachusetts General Hospital, Orthopaedic Department, Harvard Medical School, Bonston, MA, US)

Chapter 50. Marfan Syndrome and Periodontitis
(Jun-ichi Suzuki and Yasunobu Hirata, Department of Advanced Clinical Science and
Therapeutics, University of Tokyo, Tokyo, Japan, and others)

Chapter 51. Combined Pectus Correction and Aortic Valve Sparing Root Replacement in Marfan Patients
(Jean-Philippe Verhoye and Jacques Tomasi, Department of Thoracic and Cardio-Vascular Surgery, University Hospital of Rennes, rue Henri Le-Guilloux, Rennes, France)

Chapter 52. Severe Periodontitis in Marfan syndrome
(Naoto Suda, Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry, Sakado-shi, Saitama, Japan)

Chapter 53. Preimplantation Genetic Diagnosis for Marfan Syndrome
(Anver Kuliev and Svetlana Rechitsky, Reproductive Genetics Innovations, Northbrook, IL, US)

Volume 4

Chapter 54. Anuran Cytogenetics: An Overview
(Cíntia Pelegrineti Targueta, Stenio Eder Vittorazzi, Kaleb Pretto Gatto, Daniel Pacheco Bruschi, Ana Cristina P. Veiga-Menoncello, Shirlei M. Recco-Pimentel and Luciana Bolsoni Lourenço, Department of Structural and Functional Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil, and others)

Chapter 55. Human Cytogenetic Biomonitoring
(Armanda Teixeira-Gomes, Solange Costa and João Paulo Teixeira, EPIUnit – Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal, and others)

Chapter 56. Complex Karyotypes and Their Detection in Hematologic Malignancies: The Ongoing Role for Classical Cytogenetics
(Helena Urbankova, PhD, Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic)

Chapter 57. Natural Hybridization between Chromosomal Discrepant Species and the Role of Hybrid Speciation in the Genus Astyanax
(Francisco de Menezes Cavalcante Sassi, Snaydia Viegas Resende, Rubens Pazza
and Karine Frehner Kavalco, Laboratório de Genética Ecológica e Evolutiva, Universidade Federal de Viçosa, Campus Rio Paranaíba. Rio Paranaíba – MG, Brasil, and others)

Chapter 58. Trichorhinophalangeal Syndrome (TRPS) Revisited
(N. Selenti, M. Tzetis, E. Tsoutsou and H. Fryssira, Department of Medical Genetics, National and Kapodistrian University of Athens, School of Medicine, Aghia Sophia Children’s Hospital,
Athens, Greece)

Chapter 59. Epigenetic Modifications and Developmental Origin of Health and Diseases (DOHaD)
(Jia Zheng and Xinhua Xiao, Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, and others)

Chapter 60. Effects of Oxidative Stress on Epigenetic Mechanisms
(Yıldız Dincer1, PhD, and Onur Baykara, PhD, Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Biochemistry, Istanbul, Turkey, and others)

Chapter 61. Epigenetic Modifications and Their Potential Role in Tumorigenesis
(Muthu K. Shanmugam, PhD, Frank Arfuso, PhD and Gautam Sethi, PhD, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, and others)

Chapter 62. Alzheimer’s Disease: An Insight from Epigenetic Perspective
(Yıldız Dincer and Zeynep Sezgin, Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Biochemistry, Istanbul, Turkey, and others)

Chapter 63. Epigenetic Mechanisms in Cardiovascular Diseases
(Mehmet Güven, PhD, and Bahadır Batar, PhD, Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey, and others)

Chapter 64. Insights from Epigenomics Analysis of Sperm: Sperm Development and Male Infertility
(Dheepa Balasubramanian, PhD, Eisa Tahmasbpour, PhD, Ashok Agarwa, PhD, Case Western Reserve University, Cleveland, OH, US, and others)

Chapter 65. Epigenetics, Inflammation and Inflammatory Related-Diseases: A General Look
(Müge Sayitoğlu and Yücel Erbilgin, Istanbul University, Institute of Experimental Medicine,
Department of Genetics, Istanbul, Turkey)

Chapter 66. A New Molecular Approach to Obesity: Epigenetic Perspective
(Burcu Bayoglu, Ph.D. and Mujgan Cengiz, Ph.D., Istanbul University Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul, Turkey)

Volume 5

Chapter 67. Genetics and Evolution of Entomopathogenic Fungi
(A. Garcia, M. Michel, S. Villarreal, F. Castillo, E. Osorio, M. T. García-Ruiz, F. Veana,
A. C. Flores and R. Rodríguez, Food Research Department, School of Chemical Sciences,
Universidad Autónoma de Coahuila, Saltillo, Coahuila, Mexico, and others)

Chapter 68. Mitochondrial Population Genetics Inferences about the Phylogeography and Systematics of the Tayra (Eira barbara, Mustelidae, Carnivora)
(Manuel Ruiz-García, Nicolás Lichilín-Ortíz, Yolanda Mejia, Juan Manuel Ortega
and Joseph Mark Shostell, Laboratorio de Genética de Poblaciones-Biología Evolutiva,
Unidad de Genética, Departamento de Biología, Facultad de Ciencias. Pontificia Universidad Javeriana, Bogotá DC, Colombia, and others)

Chapter 69. The Precision Medicine and Precision Public Health Approaches to Cancer Treatment and Prevention: A Cross-Comparison
(Stephen M. Modell, Sharon L. R. Kardia and Toby Citrin, Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor, MI, US, and others)

Chapter 70. Neuropsychological Profile of People with Williams Syndrome (WS)
(Anne-Sophie Pezzino, Nathalie Marec-Breton and Agnès Lacroix, Center for the Psychology of Cognition, Communication and Behavior, University of Rennes, Rennes, France)

Chapter 71. Preimplantation Genetic Diagnosis (PGD) for Chromosome Rearrangements
(Chun Kyu Lim, Laboratory of Reproductive Medicine, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, Seoul, South Korea)

Chapter 72. A Family-Based Association Study between the BDNF Gene and Attention Deficit Hyperactivity Disorder in Mexican Children and Adolescents
(Alan López-López, Miriam Margot Rivera-Angles, Carlos Alfonso Tovilla-Zárate, Roberto Molina-Solís, Araceli Valencia-Hernández, Luis Gómez-Valencia, Thelma Beatriz González-Castro, Isela E Juárez-Rojop, María Lilia López-Narváez, Ana Fresan and Yazmin Hernández-Díaz, Servicio de Citogenética, Hospital Regional de Alta Especialidad, “Dr. Rodolfo Nieto Padrón”, Villahermosa, Tabasco, México, and others)

Chapter 73. Petroleum Microbiology and Genetics
(Joana Montezano Marques, Carla Thais Moreira Paixão, Gabriel Villar Monte Palma Pantoja,
Artur Luiz da Costa da Silva and Diego Assis das Graças, Federal University of Pará, Biological Sciences Institute, Center of Genomics and Systems Biology, Laboratory of Genomics and Bioinformatics, Belém, Pará, Brazil)

Chapter 74. Estrogen Activated ERs Are the Chief Genetic Safeguards of Somatic and Reproductive Health in Mammalians
(Zsuzsanna Suba, National Institute of Oncology, Surgical and Molecular Tumor Pathology Center, Budapest, Hungary)

Chapter 75. Motor Abilities are Related to Specific Genotypes in Rett Syndrome
(R. A. Fabio, T. Caprì, M. Lotan, G. E. Towey and G. Martino, Cognitive Empowerment Laboratory, Department of Cognitive Science, University of Messina, Messina, Italy, and others)

Chapter 76. A Longitudinal Study on the Development of a Boy with Fragile X Syndrome: Developmental Trends and Adaptive Changes in a Single Case Report
(María Auxiliadora Robles-Bello, PhD, Nieves Valencia-Naranjo, PhD, and David Sánchez-Teruel, PhD, Asociación Síndrome de Down de Jaén y Provincia, Department of Psychology, University of Jaén, Jaén, Spain)

Chapter 77. Cornelia De Lange Syndrome: A Review
(Elizabeth A. M. Frost, MD, Clinical Professor of Anesthesia, Icahn Medical Center at Mount Sinai, New York, NY, US)

Chapter 78. Cognitive-Behavioral Phenotype in Klinefelter Syndrome (KS) and Other Sex Chromosomal Aneuplodies (SCAs): Clinical Variability
(A. P. Verri, C. D’Angelo, A. Cremante, F. Clerici, A. Mauri and C. Castelletti, IRCCS National Neurological Institute “C. Mondino” Foundation, Laboratorio di Psicologia Cognitivo-Comportamentale, Pavia, Italy)

Chapter 79. Transcranial Direct Current Stimulation (tDCS) and Cognitive Empowerment for the Functional Recovery of Diseases with Chronic Impairment and Genetic Etiopathogenesis
(Antonio Gangemi, Tindara Caprì, Rosa Angela Fabio, Paola Puggioni, Alessandra Maria Falzone and Gabriella Martino, Cognitive Empowerment Laboratory, Department of Cognitive Science, University of Messina, Messina, Italy, and others)

Volume 6

Chapter 80. Control of Force and Timing during Unimanual and Bimanual Tapping Movements of Adolescents with Down Syndrome
(Nobuyuki Inui and Junya Masumoto, Naruto University of Education, Naruto, Japan)

Chapter 81. Management of Executive Function Following Assisted Cycling Therapy in Adolescents with Down Syndrome
(Shannon D. R. Ringenbach, Simon D. Holzapfel, Madeline Richter and Jay L. Alberts, Exercise Science and Health Promotion, Arizona State University, Phoenix, AZ, US, and others)

Chapter 82. Endocrine Features and Management of Endocrine Problems in Down Syndrome
(Stefano Stagi, Elena Sandini, Elisabetta Lapi, Perla Scalini and Maurizio de Martino, Department of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, Florence, Italy, and others)

Chapter 83. Autosomal Dominant Polycystic Kidney Disease: Pathophysiology and Treatment
(Ashraf M. Mohieldin, Viralkumar S. Upadhyay, Albert C. M. Ong and Surya M. Nauli, Department of Medicinal and Biological Chemistry, University of Toledo, Toledo, Ohio, and others)

Chapter 84. Hereditary Haemorrhagic Telangiectasia or Rendu-Osler-Weber Syndrome
(Roberto Zarrabeitia, Cristina Amado, Virginia Albiñana and Luisa-María Botella, Center for Biological Investigations (CIB), Spanish Research Council, (CSIC), Madrid, CIBERER, Spain, and others)

Chapter 85. Osteogenesis Imperfecta
(Colin R. Paterson, Formerly Reader in Medicine in the University of Dundee, Dundee, Scotland)

Chapter 86. Autosomal Dominant Disorders Associated to Breast Cancer
(Nelly Margarita Macías-Gómez, Laboratorio de Genética Humana, Departamento de Salud y Bienestar, Centro Universitario del Sur, Ciudad Guzmán, Jalisco, México)

Chapter 87. Fragile X Syndrome
(M. Milà, Servicio de Bioquímica i Genética Molecular, Hospital Clínic, Barcelona, Spain, and others)

Chapter 88. Fragile X-Associated Primary Ovarian Insufficiency (FXPOI)
(Maria-Isabel Tejada, Laboratorio de Genética Molecular, Servicio de Genética, Hospital Universitario Cruces, BioCruces Health Research Institute, Barakaldo-Bizkaia, GCV-CIBER de Enfermedades Raras (CIBERER), Spain)

Chapter 89. Fragile X-Associated Tremor/Ataxia Syndrome
(L. Rodriguez-Revenga, Biochemistry and Molecular Genetics Department, Hospital Clínic, Barcelona, Spain, CIBER de Enfermedades Raras (CIBERER), Barcelona, Spain, and others)

Chapter 90. Psychiatric Aspects in Fragile X Syndrome and Related Phenotypes
(E. Mur and M. Milà, CSM Martí i Julià. Instituto de Neuropsiquiatría y Adicciones (INAD), Parc de Salut Mar., Barcelona, Spain, and others)

Chapter 91. Clinical Features Associated with FMR1 Premutation Carriers
(M. I. Alvarez-Mora and L. Rodriguez-Revenga, Centre for Biomedical Network Research of Rare Disease (CIBERER), Barcelona, Spain, and others)

Chapter 92. Genetic Counseling of FMR1
(I. Madrigal, Biochemistry and Molecular Genetics Department, Hospital Clínic and IDIBAPS
Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Barcelona, Spain, and others)

Chapter 93. Treatment of Fragile X Spectrum: FXS, FXTAS and FXPOI
(J. Ramos and M. P. Ribate, Unidad de Genética-Pediatría, GCV-CIBERER, Hospital Clínico Universitario “Lozano Blesa”, Facultad de Medicina, Universidad de Zaragoza, Spain, and others)

Volume 7

Chapter 94. Privacy and Progress in Whole Genome Sequencing
(Presidential Commission for the Study of Bioethical Issues)

Chapter 95. Genetic Testing: Scientific Background for Policymakers
(Amanda K. Sarata)

Chapter 96. Cytogenetics to Genomics in Cancer Diagnostics
(Sharma, R. Tapadia, A. Rao and M. R. Kollabattula, Tapadia Diagnostic Centre Pvt Ltd, RTC X Roads, Hyderabad, India)

Chapter 97. Evolution of Human Genome Analysis: Impact on Diseases Diagnosis and Molecular Diagnostic Labs
(Julie Gauthier, Isabelle Thiffault, Virginie Dormoy-Raclet and Guy A. Rouleau, Medical Biological Unit, Molecular Diagnostic Laboratory, Sainte-Justine University Hospital Center, Montreal, QC, Canada, and other)

Chapter 98. Improvements in HSV-1- Derived Amplicon Vectors for Gene Transfer
(Matias E. Melendez, Alejandra I. Aguirre, Maria V. Baez, Carlos A. Bueno, Anna Salvetti, Diana A. Jerusalinsky and Alberto L. Epstein, Centre de Génétique et de Physiologie Moléculaire et Cellulaire, CNRS UMR5534, Université Claude Bernard Lyon, Villeurbanne, France, and others)

Chapter 99. Advances in Viral Genome Research of Papillomaviruses
(A. C. Freitas, A. L. S. Jesus, A. P. D. Gurgel and M. A. R. Silva, Department of Genetics,
Federal University of Pernambuco, Brazil)

Chapter 100. Synthetic Synthesis of Viral Genomes
(Monique R. Eller, Roberto S. Dias, Rafael L. Salgado, Cynthia C. da Silva and Sérgio O. De Paula, Department of Food Technology, Federal University of Viçosa, Av. PH Rolfs, s/n, Campus da UFV, Viçosa, Minas Gerais, Brazil, and others)

Chapter 101. Novel Bioinformatics Method to Analyze More than 10,000 Influenza Virus Strains Easily at Once: Batch-Learning Self Organizing Map (BLSOM)
(Yuki Iwasaki, Toshimichi Ikemura, Kennosuke Wada, Yoshiko Wada and Takashi Abe, Nagahama Institute of Bio-Science and Technology, Nagahama, Japan, and others)

Volume 8

Chapter 102. Oncogenes: Classification, Mechanisms of Activation, and Roles in Cancer Development Role of Oncogenes in Gynecological Pathology
(Ciro Comparetto and Franco Borruto, Division of Obstetrics and Gynecology, City Hospital, Prato, Italy, and others)

Chapter 103. The Classification, Mechanisms of Activation and Roles in Cancer Development of Oncogenes
(Patricio Barros-Núñez, Mónica Alejandra Rosales-Reynoso and Clara Ibet Juárez-Vázquez, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México)

Chapter 104. Dicer and MicroRNAs: Oncomirs are the Next Frontier of Oncogenes Affecting Cancer Etiology and Tumor Progression
(Ha T. Nguyen and Mandi M. Murph, American Cancer Society Research Scholar, Georgia Cancer Coalition Distinguished Cancer Scholar, University of Georgia College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences, Athens, Georgia)

Chapter 105. The Role of the Epidermal Growth Factor Receptor as a Therapeutic Target in Glioblastoma and other Malignancies
(Andrej Pala, Christian Rainer Wirtz and Marc-Eric Halatsch, Department of Neurosurgery, University of Ulm School of Medicine, Ulm, Germany)

Chapter 106. Tumor Suppressors Involved in DNA Repair and Carcinoprevention
(Yasuko Kitagishi and Satoru Matsuda, Department of Environmental Health Science,
Nara Women’s University Kita-Uoya Nishimachi Nara, Japan)

Chapter 107. Molecular Pathogenesis of Neurofibromatosis Type 1
(Ming-Jen Lee, Alton Etheridge, David J. Galas and Kai Wang, Department of Neurology and Medical Genetic, National Taiwan University School of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China, and others)

Chapter 108. Imaging of Plexiform Neurofibromas in Neurofibromatosis Type 1
(Eva Dombi, Nicholas Patronas and Brigitte Widemann, National Cancer Institute, Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD, US, and others)

Chapter 109. Surgical Treatment of Giant Neurofibromas
(Stamatis Sapountzis, Ji Hoon Kim, Abid Rashid and Hung-Chi Chen, Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan, and others)

Chapter 110. Neurofibromatosis Type 1-associated Nervous System Tumors and Current Treatment Strategies
(Nilika Shah Singhal1 and Sabine Mueller, Department of Neurology, Division of Child Neurology, University of California San Francisco, San Francisco, CA, US, and others)

Chapter 111. Outcome Measures for Optic Pathway Gliomas
(Peter M. K. de Blank, Grant T. Liu and Michael J. Fisher, Division of Pediatric Hematology-Oncology, Rainbow Babies & Children’s Hospital, Cleveland, OH, and others)

Chapter 112. Neurofibromatosis Type 1 Bone Disease: Diagnosis and Management
(Elizabeth K. Schorry and Alvin H. Crawford, Division of Human Genetics, Children’s
Hospital Medical Center, Cincinnati, OH, US, and others)

Chapter 113. Cognition and Behaviour in Neurofibromatosis Type 1: Pathogenesis and Emerging Therapies
(Jonathan M. Payne, Natalie A. Pride and Kathryn N. North, Institute for Neuroscience and Muscle Research, The Children’s Hospital at Westmead, Australia, and others)

Chapter 114. Communication Disorders Associated with Neurofibromatosis Type 1
(Heather L. Thompson, David A. Stevenson, Sean M. Redmond, Bruce L. Smith and David H. Viskochil, University of Utah, College of Health, Department of Communication Sciences and Disorders, Salt Lake City, UT, US, and others)

Chapter 115. Children with Neurofibromatosis Type 1: Functioning in the Classroom
(Yafit Gilboa, Sara Rosenblum, Aviva Fattal-Valveski and Naomi Josman, Department of Occupational Therapy, Joint program Faculty of Social Welfare & Health Sciences, University of Haifa and Technion, Haifa, Israel, and others)



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