Effects of Bempedoic Acid in Statin-Intolerant Patients with Reference to CLEAR Outcomes


Authors: Ram B Singh, Jan Fedacko, Yulia Gushchina, Nazah Hadi, Bassim Mohammad, and Oleg Medvedev
Page Range: 27-31
Published in: World Heart Journal, 15#1 (2023)
ISSN: 1556-4002

Table of Contents


Several decades of progress in lipid-lowering therapy have failed to cause adequate reduction in low-density lipoprotein cholesterol (LDL-C) level. It is still challenging, especially in patients with known or at high risk for cardiovascular disease (CVD) due to presence of atherosclerosis [1]. In these cases, statin therapy alone is often insufficient to cause appropriate reduction of CVD risk [2]. It seems that 7 to 29% of patients report adverse musculoskeletal effects which prevent them from using statins or limit their ability to receive guideline-recommended doses [2-4]. Withdrawal from statin therapy is associated with an increased risk of adverse cardiovascular events [4].

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