Early Life Nutrition, Adult Health and Development: Lessons from Changing Dietary Patterns, Famines and Experimental Studies

L.H. Lumey (Editor)
Mailman School of Public Health, Columbia University, New York, USA

Alexander Vaiserman (Editor)
Institute of Gerontology, Kiev, Ukraine

Series: Nutrition and Diet Research Progress, Public Health in the 21st Century
BISAC: HEA017000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Clinical, experimental and epidemiological studies suggest that chronic diseases may have their origin during early life and that early nutrition could be a key factor. New DNA technologies have been applied to evaluate possible long-term changes after exposure to famine in early life. These new instruments may clarify possible biological mechanisms linking early-life nutritional insults to health in adulthood. This book presents a state of the art overview of possible mechanisms for nutritional programming in relation to changes in dietary patterns. It also provides examples of nutrition deprivation in various famine settings around the world, mostly during conditions of war or political strife, and of the short and long-term outcomes after nutrition deprivation in these populations. This book includes contributions from many disciplines and represents the most comprehensive summary to date of long-term health and economic outcomes related to specific famines. The book is intended for those who are interested in the early origins of health and disease from a biological perspective, and those who want to know more about the long-term social, epidemiological and demographic consequences of specific famines in modern history. (Imprint: Nova Biomedical )

Preface pp. i-ix

(Burton Singer, Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA)
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Introduction: Early Life Nutrition and Adult Health and Development. Lessons from Changing Dietary Patterns, Famines and Experimental Studies
(L.H. Lumey, Columbia University, New York, USA, and Alexander Vaiserman, Institute of Gerontology, Kiev, Ukraine)

Section I. Developmental Programming of Adult Health and Disease: Impact of Nutrition

Chapter 1 - Undernutrition Early in Life and Adult Health: Influence of Metabolism and Body Composition
(Daniel J. Hoffman and Thaisa Lemos, Rutgers, The State University of New Jersey, Brunswick, New Jersey, USA)pp. 1-6
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Chapter 2 - Famine and the Thrifty Phenotype: Implications for Long-Term Health
(Jonathan C.K. Wells, UCL Institute of Child Health, London, United Kingdom)pp. 7-28
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Section II. Early-Life Famine and Late-Life Health: Epidemiological Evidence from Around the World pp. 29-56

Chapter 3 - The Dutch Famine of 1944-45 as a Human Laboratory: Changes in the Early Life Environment and Adult Health
(L.H. Lumey, Columbia University, New York, USA, and Frans W.A. van Poppel, NIDI, the Hague, the Netherlands)pp. 57-76
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Chapter 4 - The Health in Later Life of Channel Islanders Exposed to the 1940-45 Occupation and Siege
(George T.H. Ellison, University of Leeds, United Kingdom)pp. 77-108
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Chapter 5 - Early-Life Famine Exposure and Later-Life Outcomes: Evidence from Survivors of the Greek Famine
(Sven Neelsen, Erasmus University, Rotterdam, the Netherlands,and Thomas Stratmann, George Mason University, Virginia, USA)pp. 109-122
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Chapter 6 - Early Life Famine Exposure and Chronic Diseases in China (Yanping Li, Frank B. Hu and Guansheng Ma, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China; Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School; and Harvard School of Public Health, Boston, USA)pp. 123-144
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Chapter 7 - Early-Life Exposure to the Ukraine Famine of 1933 and Type 2 Diabetes in Adulthood
(Alexander Vaiserman, Institute of Gerontology, Mykola Khalangot, Institute of Endocrinology and Metabolism, Kiev, Ukraine; Ieva Strele Riga Stradins University, Riga, Latvia, and L.H. Lumey, Columbia University, New York, USA)pp. 145-160
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Chapter 8 - Cancer in Israeli Holocaust Survivors: The Impact of Famine?
(Lital Keinan-Boker, University of Haifa, Israel, and Neomi Vin-Raviv, Columbia University, New York, USA)pp. 161-186
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Chapter 9 - The Occupiers’ Burden: Tackling Food Shortage and Related Health Problems in Post-War Germany, 1945-47
(Filip Slaveski, School of Historical and Philosophical Studies, University of Melbourne, Australia)pp. 187-206
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Chapter 10 – Long-Term Health Consequences Following the Siege of Leningrad
(Denny Vågerö, Ilona Koupil, Nina Parfenova and Pär Sparen, Karolinska Institute and Soderntorn University, Stockholm, Sweden, Russian Academy of Medical Sciences, St. Petersburg, Russia)pp. 207-226
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Section III. Early-Life Famine Exposure and Later-Life Mortality

Chapter 11 - The Dutch Potato Famine 1846-1847: A Study on the Relationships Between Early-Life Exposure and Later-Life Mortality (Gerard J. van den Berg, Maarten Lindeboom and France Portrait, University of Manheim, Germany and VU University Amsterdam, the Netherlands)pp. 229-250
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Section IV. In Search of Mechanisms: Lessons from Experimental and Clinical Studies

Chapter 12 - Lessons from Animal Models: Mechanisms of Nutritional Programming
(Simon C. Langley-Evans, Angelina Swali and Sarah McMullen, University of Nottingham, United Kingdom)pp. 251-252
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Chapter 13 - Early Life Nutrition and Long Term Appetite Regulation (Valerie Amarger and Patricia Parnet, INRA and University of Nantes, France)pp. 253-280
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Chapter 14 - Mechanisms Underlying the Association Between Early-Life Nutrient Restriction and Development of Type 2 Diabetes
(Aleksey V. Matveyenko and Sherin U. Devaskar, David Geffen School of Medicine, Los Angeles, California, USA)pp. 281-304
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Chapter 15 - Intrauterine Growth Restriction and the Developing Vascular Tree
(Ageliki A. Karatza and Anastasia Varvarigou, University of Patras Medical School, Greece)pp. 305-330
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Index pp. 353-360

“LH Lumey and A Vaiserman address the long-term health consequences of nutritional deprivation during early development in this commendable volume of 15 chapters. While most of these accounts concern Europe during WWII, there are also chapters on the Dutch potato famine of 1846 and governmentally caused famines in the Ukraine 1933 and in China 1959-1961. These ten chapters are followed by five reviews of experimental and clinical studies. The weight of the evidence strongly supports Barker’s hypothesis on the developmental exposure to malnutrition is a factor in adult health. I imagine that the late David Barker would have had this volume on his desk, and so will I.” - Caleb Finch, Ph.D., ARCO/Kieschnick Professor of Gerontology and Biological Science and University Professor

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