DNA Damage Repair, Repair Mechanisms and Aging


Allison E. Thomas (Editor)

Series: DNA and RNA: Properties and Modifications, Functions and Interactions, Recombination and Applications

The preservation of expected life span and longevity, as well as the assurance of life succession among all species requires the integrity and faithful transcription of DNA. A dedicated machinery of DNA repair factors is responsible for reversing DNA damage across the genome. Efficient response to various effectors of DNA damage is also dependent on a complex network of sensors and mediators of stress signals which are upstream of DNA repair activation and together constitute components of the DNA damage response (DDR). This book reviews research on cell cycle checkpoints as essential mechanisms for safeguarding genome stability; nucleotide excision repair (NER) which recognizes and removes bulky DNA damage that leads to DNA double-helix distortion and others.

ISBN: N/A Categories: ,

Table of Contents

Table of Contents

Chapter 1 – DNA Instability in Premature Aging pp. 1-34
Authors / Editors: Lynne S. Cox, Ivan Boubriak, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, United Kingdom
***Open Access Chapter. Free Download Available***

Chapter 2 – Recent Advances on DNA Damage, its Repair and Genomic Stability of Green Algae Chlamydomonas Reinhardtii and other Photoautotrophic Eukaryotes pp. 35-70
Authors / Editors: Andrea Sevcovicova, Alena Hercegova, Dept of Genetics, Faculty of Natural Sciences, Comenius University Bratislava, Slovak Republic

Chapter 3 – Intra S-Phase Checkpoint pp. 71-96
Authors / Editors: Deborah Ruth Tasat, J. Sebastian Yakisich, Universidad Nacional de San Martín Buenos Aires, Argentina, and others
***Open Access Chapter. Free Download Available***

Chapter 4 – Multiplex Cell Free Assays to Apprehend DNA Repair Responses: Application to Aging Study pp. 97-122
Authors / Editors: Sylvie Sauvaigo, Anne-Laure Raffin, Jean-François Millau, Alex Nkengne, Thierry Oddos, Laboratoire Lésions des Acides Nucléiques, LCIB (UMR-E3 CEA-UJF), CEA Grenoble, INAC SCIB LAN, Grenoble, France, and others

Chapter 5 – Involvement of the cell cycle inhibitor p21CDKN1A in DNA Repair pp 123-140
Authors / Editors: Micol Tillhon, Ornella Cazzalini, Lucia A. Stivala, A. Ivana Scovassi, Ennio Prosperi, Istituto di Genetica Molecolare del CNR (IGM-CNR), Pavia, Italy. 2Dipartimento di Medicina Sperimentale, Università di Pavia, Pavia, Italy

Chapter 6 – 7, 8-Dihydro-8-oxoguanine, A Major Form of Oxidative DNA Damage, and its Repair System pp. 141-164
Authors / Editors: Takeshi Hirano, Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, Japan

Chapter 7 – Participation of Heat Shock Proteins in DNA Repair Mechanisms in Cancer pp. 165-186
Authors / Editors: Silvina Nadin, Daniel R. Ciocca, Laboratory of Tumor Biology (SN) and Laboratory of Oncology (DRC), Institute of Medicine and Experimental Biology of Cuyo, Scientific and Technological Center of Mendoza, National Research Council (CONICET) and Argentine Foundation for Cancer Research, Mendoza, Argentina

Chapter 8 – DNA Damage Repair in Testicular Germ Cells of Aging Men pp. 187-204
Authors / Editors: Moetaz El – Domyati, Hasan El- Fakahany, Denny Sakkas, Department of Dermatology, STD’s and Andrology, Al-Minya University, Al-Minya, Egypt, and others

Chapter 9 – Nucleotide-Excision Repair Deficiency: A Causative Factor for Accelerated Aging Diseases in Humans? pp.205-222
Authors / Editors: Ming Yin, Qingyi Wei, Departments of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas

Chapter 10 – Historical Development of Uncaria Preparations and their Related Bioactive Components pp. 223-236
Authors / Editors: Ronald W. Pero, Institute of Clinical Medical Sciences, Section of Immunology, Lund University, Lund, Sweden
***Open Access Chapter. Free Download Available***

Chapter 11 – DNA Damage Response and Repair: Mechanisms in Aging and Cancer pp. 237-249
Authors / Editors: Panagiotis J. Vlachostergios, Ioannis A. Voutsadakis, Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, Greece

Chapter 12 – DNA Repair Gene XPC Codon 939 Polymorphism and AFB1-Related Hepatocellular Carcinoma Risk in Guangxi Population, China pp. 251-262
Authors / Editors: Xi Dai Long, Yuan-Feng Zhou, Jin-Guang Yao, Pinhu Liao, Yu-Jin Tang, Zan-Song Huang, Bing-Pu Chen, Xiao-Ying Huang, Chao Wang, Ai-Ming Ma, Yun Yi, Qiu-Xiang Liang, Yun-Long Lu, Department of Pathology, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China, and others

Chapter 13 – Influence of Age on Expresión of DNA Repair Genes in Arabidopsis pp. 263-274
Authors / Editors: Megan J. Osmond, Bernard A. Kunz, School of Life and Environmental Sciences, Deakin University, Geelong, Victoria, Australia, and others

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