Disseminated Intravascular Coagulation (DIC): Clinical Manifestations, Diagnosis and Treatment Options


Balwinder Singh, MD (Editor)
Mayo Clinic College of Medicine, Rochester, MN, USA

Series: Recent Advances in Hematology Research
BISAC: MED038000

Disseminated Intravascular Coagulation is a devastating syndrome characterized by the systemic activation of widespread activation of the coagulation cascade and thrombosis, which may result in severe bleeding and may lead to organ failure. Recent studies have shown that the incidence of DIC is decreasing, especially in men. Despite the improvements in health care delivery, the morbidity and mortality due to DIC remains very high. Early diagnosis and accurate prognosis are important in improving the outcomes of patients with DIC. However, there is a lack of a gold standard diagnostic test to diagnose DIC and there is a scarcity of treatment or management strategies. Therefore, an understanding of the pathophysiology, ability to diagnose the DIC syndrome and treat it early, is the key.

This book provides an important timely update on the clinical manifestations, important risk factors, and treatment strategies for DIC, and provides in-depth information on pathophysiological aspects and various diagnostic scores used to diagnose DIC. Furthermore, we focused on certain important factors related to DIC such as sepsis, chronic DIC in cancer patients, coagulopathy of liver disorders vs. DIC, and DIC in urological malignancies. In addition, this book provides evidence from an important study determining the predictors influencing the hospital mortality rates of critically ill patients with DIC. This book offers a wide scope of information for physicians in all fields, whether they are intensivists, primary care physicians or oncologists, this will be an important source for identifying the DIC syndrome early, and the appropriate steps to improve patient outcomes will be taken sooner. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents

Chapter 1. Disseminated Intravascular Coagulation: Clinical Manifestations
(Akhilesh Kumar Tiwari, Michell Gulabani, Prashant Dass and Rishi Raj Sanjay, Department of Anaesthesia and Critical Care, National University Hospital, Singapore, and others)pp,1-14

Chapter 2. Risk Factors for Disseminated Intravascular Coagulation
(Akhilesh Kumar Tiwari, Rajiv Ratan Singh, Rishi Raj Sanjay, Naveen Ganjoo and Balwinder Singh, Department of Anaesthesia and Critical Care, National University Hospial, Singapore, and others)pp,15-40

Chapter 3. Thrombomodulin and Disseminated Intravascular Coagulation
(Shu-Min Lin and Han-Pin Kuo, Department of Thoracic Medicine, Chang Gung University, School of Medicine, Taipei, Taiwan)pp,41-56

Chapter 4. Diagnostic Scoring System for Disseminated Intravascular Coagulation
(R.K. Singh, Department of Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, India)pp,57-76

Chapter 5. Outcome of Critically Ill Patients with Disseminated Intravascular Coagulation in a Tertiary Care Center
(Balwinder Singh, Rabe’ Elias Alhurani and Pablo Moreno Franco,
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA, and others)pp,77-92

Chapter 6. Sepsis and Disseminated Intravascular Coagulation
(Luis Aurelio Diaz Caballero, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA)pp,93-118

Chapter 7. Coagulopathy of Liver Disease versus Disseminated Intravascular Coagulation: Who is Who?
(Pablo Moreno Franco, Jose Yataco, Balwinder Singh and Juan Canabal, Department of Transplant Department of Transplant Critical Care Service, Mayo Clinic, Jacksonville, FL, USA, and others)pp,119-142

Chapter 8. Disseminated Intravascular Coagulation in Urological Malignancy
(Aydin Pooli and Dharam Kaushik, Division of Urology, University of Nebraska Medical Center, Omaha, NE, USA)pp,143-154

Chapter 9. Chronic Disseminated Intravascular Coagulation (DIC) in Solid Tumors: When, Whom and How to Treat?
(Felice Vito Vitale, Giovanna Antonelli, Rosalba Rossello and Francesco Ferraù, Department of Oncology, Division of Medical Oncology, San Vincenzo Hospital, Taormina, Italy)pp,155-166

Chapter 10. Treatment Options for Disseminated Intravascular Coagulation
(Vaibhav Wadhwa and Kriti Kalra, Pushpanjali Crosslay Hospital, New Delhi, India, and others)pp,167-180

Index pp,181-192

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