Different Aspects on Chemotherapy of Trypanosomatids

Leonor Leon and Eduard Caio Torres-Santos (Editors)
Laboratory of Biochemistry of Trypanosomatids, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Pavilhao Leonidas Deane, Brazil

Series: Parasites and Parasitic Diseases
BISAC: MED012000

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Volume 10

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Volume 2

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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With the knowledge that there are several pieces of information concerning the chemotherapy of trypanosomatids, it is important to put together the different aspects of this subject. This book is an updated version of several areas such as molecular biology, biochemistry, immune response to the studied compounds, pharmacology, etc. The chapters were written by experts in those different specialties.

It reinforces the necessity to look to those trypanosomatids associated with severe diseases, such as Chagas disease, leishmaniases and African trypanosomiasis, which constitute a public health problem in poor countries where basic sanitary conditions are non-existent. This book intends to show the importance of specific methodologies to save time and money during the drug development process. Each step should be carefully planned from the selection of test compounds, the choice of a molecular target within parasites, the definition of a lead compound and the adequacy of the animal models.

It is also important to focus on the activity of compounds, synthetic or from natural sources, in different species and life stages of the parasites, besides the way these compounds are metabolized in these laboratory conditions.

In conclusion, this book will bring you information that could stimulate the development of better treatments for these highly neglected diseases.

Preface

Chapter 1. The Anti-Trypanosomatids Drug Discovery Process: An Overview
Eduardo Caio Torres-Santos and Leonor L. Leon (Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil)

Chapter 2. The Application of Pharmacological Concepts in Drug Discovery and Development
Juliana da Silva Pacheco, Viviane dos Santos Faiões, Gil Mendes Viana and Edézio Ferreira da Cunha-Júnior (Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil, and others)

Chapter 3. Experimental Models of Trypanosomatid Infection
Patrícia Maria Lourenço Dutra and Silvia Amaral Gonçalves Da Silva (Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil)

Chapter 4. Immunological Aspects of Leishmania Infection
Karen dos Santos Charret and Raquel Ferreira Rodrigues (Laboratório de Biologia Molecular e Doenças Endêmicas / Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil)

Chapter 5. The Oxidative Metabolism in Trypanosomatids: Implications for these Protozoa Biology and Perspectives for Drugs Development
Ana Cristina Souza Bombaça and Rubem Figueiredo Sadok Menna-Barreto (Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil)

Chapter 6. Molecular Biology for Anti-Trypanosomatid Drug Discovery and Target Elucidation
Valter Viana Andrade-Neto and Rubens L Monte-Neto (Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil / Laboratório de Parasitologia Celular e Molecular - Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Minas Gerais, Brazil)

Chapter 7. Natural Products as a Source of Leishmanicidal Compounds
Gabrielle B. Barcellos, Luiza Gervazoni F. de Oliveira and Elmo E. Almeida-Amaral (Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo cruz, Rio de Janeiro, Brazil)

Chapter 8. Recent Advances in Drug Development for Chagas Disease: Two Magic Words, Combination and Repositioning
Kelly Salomão and Solange Lisboa de Castro (Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil)

Chapter 9. Recent Advances in the Treatment of Leishmaniases
Andre Gustavo Tempone (Centre for Parasitology and Mycology, Instituto Adolfo Lutz, Secretary of Health of São Paulo, São Paulo, SP, Brazil)

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