Diclofenac: Pharmacology, Uses and Adverse Effects

Eugenia Yiannakopoulou (Editor)
Department of Medical Laboratories, Faculty of Health and Caring Professions, Highest Technological Educational Institute of Athens (ATEI), Athens, Greece

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Although the non steroidal anti-inflammatory agent diclofenac is an old drug, there is ongoing research interest on potential novel indications of the drug, on adverse drug reactions of diclofenac and on the management of these adverse drug reactions. This book aims to contribute knowledge on novel aspects of the pharmacology of diclofenac. Thus, the book provides evidence on three fields: (i) potential novel indications of diclofenac, especially in oncology, (ii) adverse events of diclofenac and (iii) modulation of gastrointestinal and cardiovascular toxicity of diclofenac.

The book titled ‘Diclofenac: Pharmacology, Uses and Adverse Events’ is focused on the above areas, contributing evidence on:
• the anticancer effects of diclofenac,
• the modulation of stress response by diclofenac ,
• rare severe adverse reactions of diclofenac,
• thyroid effects of diclofenac,
• maternal and fetal adverse reactions of diclofenac and
• the modulation of gastrointestinal
• the modulation of cardiovascular toxicity of diclofenac.

All the chapters are well-written and structured and appropriately referenced. The authors present their own research work and at the same time they provide a well-informed literature review.

The book will be interesting for researchers with interest in diclofenac, academic teachers, medical doctors, pharmacologists, pharmacists, and medical students.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Anticancer Effects of Diclofenac: A Multitarget Approach
(Eugenia Yiannakopoulou, MD, PhD, Department of Biomedical Sciences Faculty of Health Sciences University of West Attica, Athens, Greece)

Chapter 2. Targeting Stress Response with Diclofenac
(Eugenia Yiannakopoulou, Department of Biomedical Sciences Faculty of Health and Caring Professiona, University of West Attica, Athens, Greece)

Chapter 3. Diclofenac and Severe Adverse Reactions
(Eugenia Yiannakopoulou, Department of Biomedical Sciences Faculty of Health and Caring Sciences, University of West Attica, Athens, Greece)

Chapter 4. Thyroid Effects of Diclofenac
(Eugenia Yiannakopoulou, Department of Biomedical Sciences, Faculty of Health Sciences University of West Attica, Athens, Greece)

Chapter 5. The Use of Diclofenac in Pregnancy: Fetal and Neonatal Effects
(Esther López del Cerro, Llanos Belmonte Andújar, Carolina Serrano Diana, Ana María Castillo Cañadas, María Dolores Díaz Serrano and María Teresa Gómez García, Obstetrics and Gynecology Department. University and Hospital of Albacete, Spain, and others)

Chapter 6. The Use of Diclofenac in Obstetrics and Gynecology: Indications, Efficacy and Adverse Effects
(Esther López del Cerro, Llanos Belmonte Andújar, Ana Fuentes Rozalen, Lucía Candela Feliu, Carolina Serrano Diana, Azucena Tello Muñoz and María Teresa Gómez García, Obstetrics and Gynecology Department. University and Hospital of Albacete, Spain, and others)

Chapter 7. Novel Approaches to Manage Toxicity of Diclofenac in the Gastrointestinal Tract
(Sumanta Kumar Goswami, Guang-Yu Yang, Aldrin Gomes and Bruce D. Hammock, Department of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, US, and others)

Chapter 8. Mitochondrial and Proteasomal Dysfunction as a Possible Mechanism of Cardiovascular Toxicity of Diclofenac
(Sumanta Kumar Goswami, Guang-Yu Yang, Shuchita Tiwari, Bruce D. Hammock and Aldrin Gomes, Department of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, US, and others)

Index

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