Diagnostics and Therapeutic Applications of Nanotechnology and Nanomedicine in Oral Squamous Cell Carcinoma

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Authors: Rajib Dhar, Gauresh Gurudas Shivji, and Arikketh Devi
Page Range: 207-221
Published in: Journal of Stem Cells, Volume 16 Issue 4
ISSN: 1556-8539

Table of Contents

Abstract

Oral squamous cell carcinoma (OSCC) is the most common cancer worldwide. Several factors influence OSCC, tobacco use having a high impact on OSCC development. The prevention of OSCC may be possible by reducing exposure to the risk factors of OSCC. OSCC is the sixth most deadly cancer globally, owing to the drawback of the traditional approach in OSCC treatment and failure of diagnosis at an early stage. The primary stage of detection and a sedentary lifestyle mainly contributes to the morbidity and mortality of OSCC patients. In this scenario, nanotechnology gives a new direction for the treatment and diagnosis of oral cancer. Nanomedicine shows a highly promising result with low toxicity. The toxicity of nanomaterial can be controlled by improving functionalization and systematically minimizing toxicity. As a result, nanomaterial and nanomedicine becomes more biologically compatible. Nanomedicine-based targeted drug delivery to the tumor site releases therapeutic agents most effectively, possibly increasing the efficacy of nanomedicine. This book chapter aims to cover the recent developments in Nanotechnology-based drug delivery systems, advance nanomedicines (Nano-capsules, Gold nanoparticles, Quantum dots, and Carbon nanotubes) and their diagnostics as well as therapeutic applications in OSCC.

Keyword: oral squamous cell carcinoma, nanomedicine, drug delivery