Diabetes-Induced Diabetic Cardiomyopathy and Sudden Cardiac Death via the Generation of the Reactive Carbonyl Species, Methylglyoxal

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Authors: Jaipaul Singh, Sunil Rupee, Carlin Hanoman, Khemraj Rupee, Jan Fedacko, Keshore R. Bidasee, and Fedal Alomar
Page Range: 89-92
Published in: World Heart Journal, 15#2 (2023)
ISSN: 1556-4002

Table of Contents

ABSTRACT

Diabetes mellitus (DM) is due to a number of risk factors leading to hyperglycemia (HG), which can induce the generation of the reactive carbonyl species, methylglyoxal (MGO) via a down-regulation of the enzyme, glyoxylase-1 (Gly-1) that degrades MGO. MGO in turn can elicit deleterious effects to cellular calcium transporting proteins in the heart, resulting in cardiac dysfunction and diabetic cardiomyopathy (DC), and even sudden cardiac death (SCD) of the patient. Gene therapy to elevate the levels of Gly-1 to degrade MGO to physiological level can prevent the demise of the myocardium, resulting in normal function.

Keywords: Calcium heart, diabetes mellitus, diabetic cardiomyopathy, methylglyoxal

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