Dexamethasone: Therapeutic Uses, Mechanism of Action and Potential Side Effects


Alexandre Sauvage (Editor)
Maxime Levy (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

Dexamethasone is a potent, long-term acting synthetic glucocorticoid class of steroid drugs that have anti-inflammatory and immunosuppressant properties. The authors in this book discuss the therapeutic uses, mechanisms of action and potential side effects of dexamethasone. Topics include dexamethasone for the treatment of meconium aspiration syndrome (MAS); dexamethasone effects in hyperinfection syndrome due to strongyloidiasis; dexamethasone use in retinal disease and anti-tumor activities; perioperative uses of dexamethasone; comparison between cortisol and dexamethasone negative feed-back action in humans; the effect of dexamethasone on parathyroid hormone-related protein expression by oral cancer cells; and the effects of dexamethasone on the proliferation and differentiation of osteoblasts. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Dexamethasone in the Treatment of Meconium Aspiration Syndrome: Benefits versus Side Effects
(Daniela Mokra, Juraj Mokry, Ingrid Tonhajzerova, Department of Physiology and Pharmacology, Jessenius Faculty of Medicine, Comenius University, Mala Hora, Martin, Slovakia)

Dexamethasone Effects in Hyperinfection Syndrome Due to Strongyloidiasis
(Cristiane Tefé-Silva, Daniela I. Souza, Eleuza R. Machado, Karina M. Mata, Margaret de Castro, Lúcia H. Faccioli, Simone G. Ramos, Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil, and others)

Dexamethasone’s Uses in Retinal Diseases
(Zeljka Smit-McBride, Sara P. Modjtahedi, Lawrence S. Morse, University of California at Davis, School of Medicine, Department of Ophthalmology, Davis, CA, and others)
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Anti-Tumor Activities of Dexamethasone
(Hitoshi Ishiguro, Takashi Kawahara, Yi Li, Hiroshi Miyamoto, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA)

Perioperative Uses of Dexamethasone
(Ivan Parra-Sanchez, Carolina Parada, Kenneth C. Cummings III, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, and others)

Comparison between Cortisol’s and Dexamethasone’s Negative Feedback Action in Humans: Evidence for Preferential Sensitivity to the Natural Glucocorticoid
(Roberta Giordano, Valentina D’Angelo, Clizia Zichi, Federica Guaraldi, Marco Minetto, Ezio Ghigo, Emanuela Arvat, Department of Biological and Clinical Sciences, Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Italy)

Effect of Dexamethasone on Parathyroid Hormone-related Protein Expression by Oral Cancer Cells
(Masatoshi Abe, Division of Chemistry, Department of Biomaterials Science, Ohu University School of Dentistry, Misumido, Tomita-machi, Koriyama, Japan)

The Effects of Dexamethasone on the Proliferation and Differentiation of the Osteoblasts
(Jun-Beom Park, Department of Periodontics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea)


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