Dermal Fibroblasts: Histological Perspectives, Characterization and Role in Disease

Xiaowen Bai (Editor)
Department of Anesthesiology, Division of Research, Medical Education Building, Milwaukee, WI

Series: Dermatology – Laboratory and Clinical Research
BISAC: MED017000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Dermal fibroblasts are the most numerous cells within the dermal layer of skin. The main function of fibroblasts is to preserve the structural integrity of skin through constantly secreting extracellular matrix. Various factors diversely affect the secretion activities of fibroblasts and may lead to varying disease processes (e.g., solar damage and wrinkles). This book gathers important cutting-edge research in the field of fibroblasts covering characterization of fibroblasts and their roles in multiple disease processes such as hypertrophic scarring, aging/photoaging, diabetic wound healing, cancer, and pachydermoperiostosis.

In addition, the chapters also deal with the stem cell-like properties of fibroblasts, which sheds new light on the commonly used definition of fibroblasts and provides novel insights into many past studies performed with fibroblast preparations, since the reported effects might be greatly attributable to stem cell content within these fibroblasts. Additionally, this book features an introduction of the reprogramming of dermal fibroblasts into patient-specific induced pluripotent stem cells (iPSCs) that can be converted into varying terminally differentiated cells. Application of iPSCs is a rapidly developing research field because reprogrammed iPSCs from dermal fibroblasts provides a great tool for studying molecular mechanisms of disease, development, and tissue regeneration. This book is certain to have broad appeal and should provide a useful resource for researchers, students, teachers, and physicians interested in the field. (Imprint: Nova Biomedical )

Preface

Chapter 1. The Influence of Low Intensity Laser Irradiation on Dermal Fibroblasts and Its Role in Diabetic Wound Healing
(Nicolette N. Houreld, Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, South Africa)

Chapter 2. Abnormal Calcium Release by Angiotensin II and Growth Rate in Skin Fibroblasts from Type I Diabetic Patients with Diabetic Nephropathy
(Renato Millioni, Giulio Ceolotto, Roberto Trevisan, Elisabetta Iori, Department of Medicine, Via Giustiniani, University of Padova, Padova, Italy, and others)

Chapter 3. Skin Connective Tissue Aging and Dermal Fibroblasts
(Taihao Quan, Department of Dermatology, University of Michigan
Medical School, Ann Arbor, MI, USA)

Chapter 4. Role of Dermal Fibrobasts in Post-burn Hypertrophic Scarring
(Jian Fei Wang, Saad M. Alrobaiea and Edward E. Tredget, Wound Healing Research Group, Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada, and others)

Chapter 5. Role of Stromal Fibroblasts in Cancer Originated from Squamous Epithelia
(Karel Smetana, Jr., Barbora Dvoøánková, Pavol Szabo, Hynek Strnad and Michal Koláø, Charles University in Prague, 1st Faculty of Medicine, Institute of Anatomy, Prague, Czech Republic, and others)

Chapter 6. The Role of Fibroblasts in Cancer Prone Genodermatoses
(Yannick Gache and Thierry Magnaldo, Genetics and Physiopathology of Epithelial Cancers, Institute For Research on Cancer and Aging, Nice/ IRCAN, School of Medicine, Nice University, France)

Chapter 7. Dermal Fibroblasts in Pathomechanism of Pachydermoperiostosis
(Jun-ichi Sakabe, Yoshiki Tokura and Kenji Kabashima, Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan, and others)

Chapter 8. Stem Cell-like Characteristics of Dermal Fibroblasts: Proliferation, Antigen Profiles, and Differentiation Capacity
(Xiaowen Bai, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA)

Chapter 9. Production of Natural Type Interferon Beta and many other Cytokines in Human Diploid Fibroblasts Derived from Neonatal Foreskins
(Emiko Sano, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Japan)
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Chapter 10. Reprogramming of Dermal Fibroblasts to Induced Pluripotent Stem Cells and Cardiomyocytes
(Dongrui Ma and Reginald Liew, Research and Development Unit, National Heart Center of Singapore, Singapore, and others)

Index

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