Deciphering Insect Immunity: New Insights from RNA Interference

Davide Malagoli and Mauro Mandrioli
University of Modena and Reggio Emilia, Modena, Italy

Series: Insects and Other Terrestrial Arthropods: Biology, Chemistry and Behavior
BISAC: SCI086000

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Volume 10

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Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Insect and vertebrate evolutionary histories are separated by more than 500 million years, but the molecular bases of several fundamental biological functions, including innate immune response, seem to have been conserved during metazoan diversification. As a consequence, insects represent good models for gaining new insights into biological basis of human immune-surveillance and pathology. Gene silencing consists in several fruitful techniques, such as the production of loss-of-function mutants and RNA interference. These methods, when applied to models for which molecular databases are available, allow the genetic dissection of several immune-related processes and pathways. This book examines the recent advances on insect immunity derived from the application of gene silencing techniques in Drosophila melanogaster and Anopheles gambiae. (Imprint: Nova)

Abstract

Introduction

Cell-mediated immunity

Humoral immunity

RNAi as a natural anti-viral process in D. melanogaster and A. gambiae

Conclusion

Acknowledgments

References

Index

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