Cytoskeletal Controls on Transcription of the SERPINE1 (PAI-1) and CCN2 (CTGF) Genes: Implications for Human Fibrotic Disease

Rohan Samarakoon and Paul J. Higgins
Center for Cell Biology and Cancer Research Albany Medical College, Albany, New York, USA

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: MED107000

Clear

$0.00

Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

eBook

Digitally watermarked, DRM-free.
Immediate eBook download after purchase.

Product price
Additional options total:
Order total:

Quantity:

ISBN: N/A Categories: , Tags: ,

Details

Architectural constraints imposed by the three major, highly interactive, cytoskeletal networks (consisting of the microtubule, microfilament and intermediate filament systems), cell-to-cell junctional complexes, integrin-extracellular matrix (ECM) interactions and external forces are significant determinants of cell structure/function. This is, perhaps, best evident in the vascular compartment which is constantly subjected to a continuum of hemodynamic stimuli that alter microfilament and microtubule organization and the associated signaling pathways, several elements of which are now known to be “hard-wired” to the cytoskeleton. Dissection of pathways and mechanisms underlying vascular cell shape-deformation responses may lead to the identification of new, translationally-relevant, targets for the treatment of vascular disorders. (Imprint: Nova)

Preface

Introduction

Mechanochemical Signaling: the Vascular System Model

Cytoskeletal Deformation and Downstream Responses

Growth Factor Receptor Transactivation and Downstream Signaling Following Microtubule Disruption

Conclusions

References

Index

You have not viewed any product yet.


SHOW ALL OF MY RECENTLY VIEWED BOOKS