Cytoskeletal Controls on Transcription of the SERPINE1 (PAI-1) and CCN2 (CTGF) Genes: Implications for Human Fibrotic Disease
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Rohan Samarakoon and Paul J. Higgins
Center for Cell Biology and Cancer Research Albany Medical College, Albany, New York, USA
Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: MED107000
Architectural constraints imposed by the three major, highly interactive, cytoskeletal networks (consisting of the microtubule, microfilament and intermediate filament systems), cell-to-cell junctional complexes, integrin-extracellular matrix (ECM) interactions and external forces are significant determinants of cell structure/function. This is, perhaps, best evident in the vascular compartment which is constantly subjected to a continuum of hemodynamic stimuli that alter microfilament and microtubule organization and the associated signaling pathways, several elements of which are now known to be “hard-wired†to the cytoskeleton. Dissection of pathways and mechanisms underlying vascular cell shape-deformation responses may lead to the identification of new, translationally-relevant, targets for the treatment of vascular disorders. (Imprint: Nova)