Cytochromes b and c: Biochemical Properties, Biological Functions and Electrochemical Analysis


Rurik Thom (Editor)

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI049000

Despite the fact that over 200 phosphorylation sites have been mapped on the mitochondrial oxidative phosphorylation (OxPhos) complexes, very little is known about the relevant cell signaling pathways and the terminal kinases and phosphatases that control these phosphorylations. Within OxPhos, cytochrome c (Cytc) plays a special role because it is not only involved in electron transport but is also a key executer of apoptosis when it is released from the mitochondria.

In this book, the authors present further research on the study of cytochrome C as well as cytochrome B. Some of the topics discussed in the book include the regulation of cytochrome C in respiration as well as its role in apoptosis. It also focuses on the structural aspects and touches base on cytochrome B5 as a pleiotropic metabolic modulator. (Imprint: Nova)


Table of Contents

Table of Contents


Chapter 1 – Regulation of Cytochrome c in Respiration, Apoptosis, Neurodegeneration and Cancer: The Good, the Bad and the Ugly (pp. 1-38)
Maik Hüttemann, Jeffrey W. Doan, Anton-Scott Goustin, Christopher Sinkler, Gargi Mahapatra, Joseph Shay, Jenney Liu, Hosam Elbaz, Siddhesh Aras, Lawrence I. Grossman, Yuchuan Ding, Steven P. Zielske, Moh H. Malek, Thomas H. Sanderson and Icksoo Lee (Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA, and others)
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Chapter 2 – Cytochrome b5 as a Pleiotropic Metabolic Modulator in Mammalian Cells (pp. 39-80)
Alejandro K. Samhan-Arias and Carlos Gutierrez-Merino (Department of Biochemistry and Molecular Biology, School of Sciences, University of Extremadura, Avenida de Elvas, Badajoz, Spain)
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Chapter 3 – Cytochrome c–Lipid Interaction in the Regulation of Cell Fate: Respiration, Apoptosis and Diseases (pp. 81-102)
Laura Fiorucci, Federica Sinibaldi and Roberto Santucci (Department of Clinical Sciences and Translational Medicine, University of Rome ‘Tor Vergata’, Italy, and others)

Chapter 4 – The Role of Cytochrome c in Apoptosis: Recent Revelations (pp. 103-120)
Thomas Brittain (School of Biological Sciences, University of Auckland, Auckland, New Zealand)

Chapter 5 – Redox-Active Silver(I) Complexes with Sterically Hindered 1,2-Dihydroxybenzene Derivatives: Reduction of Cytochrome c and Antimicrobial Activity (pp. 121-172)
N. V. Loginova, T. V. Koval’chuk, N. P. Osipovich, Y. V. Faletrov, Yu. S. Halauko, G. I. Polozov, A. T. Gres’, H. I. Harbatsevich, A. V. Hlushko, R. A. Zheldakova and V. M. Shkumatov (Faculty of Chemistry, Belarusian State University, Minsk, Belarus, and others)

Chapter 6 – Structural Aspects of Cytochrome c-Cardiolipin Interactions: Förster Resonance Energy Transfer Study (pp. 173-224)
Valeriya M. Trusova, Julian G. Molotkovsky, Paavo K. J. Kinnunen and Galyna P. Gorbenko (Department of Nuclear and Medical Physics, V. N. Karazin Kharkov National University, Kharkov, Ukraine, and others)

Chapter 7 – The Involvement of Cytochrome c Oxidase in Aluminium Neurotoxicity (pp. 225-252)
Ankica Jelenković, Marina D. Jovanović and Nataša Petronijević (University of Belgrade, Institute for Biological Research “Siniša Stanković”, Belgrade, Republic of Serbia, and others)



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