Cytochrome P450 Enzymes: Biochemistry, Pharmacology and Health Implications

Jian Wu, MD, PhD (Editor)
Key Laboratory of Medical Molecular Virology, Fudan University Shanghai Medical College, Shanghai, China

Series: Biochemistry Research Trends, Neuroscience Research Progress
BISAC: SCI007000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Cytochrome P450 (CYP) is a super family of phase I enzyme in the biotransformation of xenobiotics and medications. Most medications undergo deactivation by CYP, and then are eliminated through either bile or kidneys from the body. CYP isozymes play a crucial role in drug interactions that may result in enhanced toxicity, reduced efficacy or onset of adverse reactions. On the other hand, many agents affecting CYP expression and activity may alter metabolic rate of different medications co-administrated.

Therefore, the molecular basis, regulation by inducers or inhibitors, and pharmacologic reaction of specific CYP isozymes are the key issues of biochemical mechanisms, pharmaceutical development and safe use of various medications. This book is to meet the needs from basic molecular biochemists, pharmacologists, pharmacists, medical students, clinical practitioners and scientists, as well as broad readers who wish to understand how an herbal extract, medication or natural supplement is metabolized or transformed in the liver or other sites for deactivation and elimination. Special focuses are paid to herbal extracts and medications in the treatment of neuro-psychiatric or cardiovascular disorders, diabetes and viral hepatitis. Detailed dissection of drug interactions in a particular field intends to provide rationales for useful guidance of safe drug use in daily practice.

The contributing authors are basic scientists, pharmacists, pharmacologists and on-service physicians in cardiovascular, neuro-psychiatric, gastroenterologic and hepatologic fields from Europe (Germany, France, Portugal), Australia, the US and China. Thus, the book is the collection of master pieces by well-known experts from various regions of the world, and represents the current understanding of CYP enzyme reaction and a contemporary coverage of possible drug interactions in involved fields. The featured chapters are scientific elucidation of basic biochemistry, pharmacology and clinical investigations in the interest of drug metabolism, interaction and safe use guidance in the single focus of this microsomal enzyme with multi-facet metabolic function. (Imprint: Nova)

Preface

Chapter 1 - Cytochrome P450: Electron Transfer and Sensors (pp. 1-12)
Frieder W. Scheller,, Aysu Yarmana, and Ulla Wollenberger (Fraunhofer Institute for Biomedical Engineering IBMT, Potsdam, and Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany)

Chapter 2 - Cytochrome P450-Mediated Toxicity of Therapeutic Drugs (pp. 13-50)
Mariana Matias, Catarina Canário, Samuel Silvestre, PhD, Amílcar Falcão, PhD, and Gilberto Alves, PhD (Health Sciences Research Centre, University of Beira Interior, Covilhã; Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, and Department of Pharmacology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal)

Chapter 3 - Evaluation of Cytochrome P450 Enzymesin Drug Interactions (pp. 51-86)
Xin Wang, Ph.D. (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China)

Chapter 4 - Cytochrome P450 Enzymes in Atherosclerosis (pp. 87-106)
Iryna Voloshyna and Allison B. Reiss (Winthrop University Hospital, Mineola, NY, US)

Chapter 5 - Drug Resistance of Nucleos(T)Ide Analogues and Related Adverse Events in Chronic Hepatitis B (pp. 107-120)
Li Zong (School of Basic Medical Sciences, Fudan University, Shanghai, China)

Chapter 6 - Metabolism, Interaction and Use Guidelines of Anti-HBV and Anti-HCV Medications (pp. 121-140)
Jinsheng Guo and Jian Wu (Key Laboratory of Medical Molecular Virology, Fudan University Shanghai Medical College, Shanghai, China; Dept. of Gastroenterology, and Shanghai Institute of Liver Disease, Fudan University Affiliated Zhongshan Hospital, Shanghai, China)

Chapter 7 - Role of Cytochrome P450 Enzymes in Psychotropic Drug Metabolism and Clinical Implications (pp. 141-180)
Irina Piatkov, PhD and Trudi Jones (University Clinic and Research Centre, Blacktown Hospital, Western Sydney Local Health District, New South Wales, Australia)

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