Cytochrome c: Roles and Therapeutic Implications

Natalia Arias (Editor)
Research Associate, IDLH, University College of London

Series: Neuroscience Research Progress
BISAC: MED057000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Cytochrome c: Roles and Therapeutic Implications provides a thoroughly revised, invaluable resource for university students and researchers in the life sciences, medicine and related fields. This esteemed text attempts to organize available information on this topic to help a better understanding of the role of cytochrome c oxidase and its functional interaction with cytochrome c (Cyt c), the network of oxidation-reduction processes of cyt c in the cell with an emphasis on the implications for apoptosis induction and possible roles of cyt c reducing agents as an attractive strategy to improve neurodegenerative pathologies or cancer.

In this book, the authors also reviewed the advantages of cytochrome c oxidase histochemistry to disentangle brain substrates underlying different kinds of learning and memory, from memory engram being retrieved with an untrained hippocampus to its power to identify sensory areas in the teleost fish. Finally, the authors will explore different approaches in cell cultures, animal models, and clinical trials to enhance cytochrome c oxidase activity that lead to improve brain respiratory metabolism, namely, methylene blue and photobiomodulation. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves, providing the potential of cytochrome c to lead a revolution in the way neurodegenerative disorders are treated.
(Imprint: Nova)


Chapter 1. Cytochrome c Reducing Agents and Antiapoptotic Action of Antioxidants
(Ricardo Lagoa and Carlos Gutierrez-Merino, ESTG, Polytechnic Institute of Leiria, Leiria, Portugal, and others)

Chapter 2. Interaction of Cytochrome c with Redox-Active Dihydroxybenzene-Containing Antimicrobials: Application to Antioxidant Characterization
(N.V. Loginova, H.I. Harbatsevich, G.A. Ksendzova, N.P. Osipovich, Yu.S. Halauko, Y.V. Faletrov, S.I. Stakhevich and K.A. Nabebina, Department of Chemistry, Belarusian State University, Minsk, Belarus, and others)

Chapter 3. The Role of Cytochrome c Oxidase Deficit and Its Adverse Interaction with Cytochrome C Deficiency in Aging
(Mariana E. Jung, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, US)

Chapter 4. Cytochrome c as a Clinical Biomarker in Diseases Characterized by Cell Apoptosis
(Laura Fiorucci, Federica Sinibaldi, Maria Sole Chimenti, Roberto Perricone and Roberto Santucci, Department of Clinical Sciences and Translational Medicine, University of Rome ‘Tor Vergata’, Italy, and others)

Chapter 5. Developmental and Sexual Differences Revealed by Cytochrome Oxidase Activity
(Magdalena Mendez-Lopez and Marta Mendez, IIS Aragón, Departmento de Psicología y Sociología, Universidad de Zaragoza, Zaragoza, Spain, and others)

Chapter 6. Cytochrome c Oxidase as a Useful Tool in Learning and Memory Research
(Magdalena Mendez-Lopez and Marta Mendez, IIS Aragón, Departmento de Psicología y Sociología, Universidad de Zaragoza, Zaragoza, Spain)

Chapter 7. Cytochrome c Oxidase Histochemistry and Reversible Hippocampal Lesions to Understand Spatial Memory
(José Manuel Cimadevilla, Department of Psychology, University of Almería, Spain)

Chapter 8. Quantitative Cytochrome Oxidase Histochemistry as a Useful Technique to Measure Subregional Brain Activity in Neurobehavioral Studies in Teleost Fish
(Francisco M. Ocaña, Antonia Gómez, Emilio Durán, Cosme Salas, Fernando Rodríguez and Cristina Broglio, Laboratory of Psychobiology, University of Sevilla, Sevilla, Spain)

Chapter 9. Cytochrome c Oxidase and Its Therapeutic Implications
(Camino Fidalgo and Natalia Arias, IIS Aragón, Departamento de Psicología y Sociología, Universidad de Zaragoza, Zaragoza, Spain, and others)


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