Cystic Tumors of the Pancreas

Robert Grützmann, M.D., Ph.D. (Editor)
Department of Surgery, University Hospital Erlangen, Germany

Series: Endocrinology Research and Clinical Developments
BISAC: MED027000

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Cystic tumors of the pancreas today are diagnosed more frequently in clinical practice, mainly due to an increased use of the modern advanced imaging modalities.

Bland cysts of the pancreas most often develop after chronic or acute inflammation of the pancreas. However, the current knowledge concerning the development of cystic neoplasias of the pancreas is still rudimentary.

Histopathologically, 90% of pancreatic cystic neoplasias are represented by four types: serous microcystic (SCN), mucinous cystic (MCN), intraductal papillary mucinous (IPMN) and solid pseudopapillary (SPN) neoplasias. Surgical treatment of these lesions can be highly challenging and occasionally demands complex surgical approaches that should be put in the hands of skilled pancreatic surgeons in experienced high-volume centers.

While some of the described cystic tumors are harmless, such as SCNs of the pancreas, others such as IPMN and MCN harbor relevant malignant potential. The differential diagnosis of these lesions is critical for the patient- but often difficult. In addition, surgical treatment, even in the hands of skilled surgeons in centers of pancreatic surgery, can be complicated and can result in relevant morbidity and mortality.

Therefore, it is of great importance for all doctors treating and advising patients with cystic tumors of the pancreas, i.e. surgeons, gastroenterologists, radiologists and pathologists as well as for the general practitioner, to have funded knowledge in regard to epidemiology, pathology, diagnostics and prognosis of the various pancreatic lesions, regardless of the necessity for surgical treatment.

Together with recognized specialists in this field from Europe, the United States, and Japan, the authors offer a broad and detailed overview over diagnosis and the current treatment strategies for patients with cystic tumors of the pancreas. (Imprint: Nova Biomedical)

Preface

Acknowledgment

Introduction
R. Grützmann (Department of Surgery, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany)

Section I. Epidemiology

Chapter 1. Epidemiology of Cystic Pancreatic Tumors
Matthias Maak and Robert Grützmann (Department of Surgery, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany)

Section II. Diagnostics

Chapter 2. Clinical and Laboratory Diagnostic Parameters
Nikolaos Vassos, MD (Department of Surgery, University Hospital Erlangen, Germany)

Chapter 3. Imaging of Cystic Pancreatic Tumors
Verena Plodeck (Department of Radiology, University Hospital Dresden, Germany)

Chapter 4. Gastroenterological Diagnosis
Roberto Valente, Marco Del Chiaro, Miroslav Vujasinovic, Urban Arnelo, and Matthias Löhr (CLINTEC - Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden, and others)

Section III. Histology

Chapter 5. Histology of Pancreatic Cystic Tumors
Lena Häberle and Irene Esposito (Institute of Pathology, Heinrich-Heine University of Duesseldorf, Duesseldorf, Germany)

Section IV. Molecular Background

Chapter 6. Molecular Biology of Pancreatic Cystic Tumors
Hai Yang and Christian Pilarsky (Department for Surgical Research, Universitätsklinikum Erlangen, Erlangen, Germany)

Section V. Surgery

Chapter 7. Surgical Procedures
D. Raptis, M. Maak and R. Grützmann (Department of Surgery, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany)

Section VI. Diagnostic and Therapeutic Particularities of Specific Tumor Entities

Chapter 8. Serous Cystic Neoplasms of the Pancreas
Emrullah Birgin, MD and Felix Rückert, MD, PhD (Surgical Department, University Hospital Mannheim, Mannheim, Germany)

Chapter 9. IPMN
G. F. Weber and R. Grützmann (Department of Surgery, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany)

Chapter 10. Mucinous Cystic Neoplasms
Katherine Albutt, MD and Cristina Ferrone, MD (Department of General & Gastrointestinal Surgery, Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts, US)

Chapter 11. Rare Cystic Tumors of the Pancreas
Ulrich Friedrich Wellner and Tobias Keck (Clinic of Surgery, UKSH Campus Lübeck, Lübeck, Germany)

Section VII. Follow-Up

Chapter 12. Surveillance and Follow-Up of Cystic Tumors
Takayuki Anazawa, MD, PhD, Kyoichi Takaori, MD, PhD, Toshihiko Masui, MD, PhD, and Shinji Uemoto, MD, PhD (Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan)

Section VIII. Clinical

Chapter 13. Clinical Examples
Stephan Kersting and Robert Grützmann (Department of Surgery, University Hospital of Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany)

Index

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