Cysteine: Biosynthesis, Chemical Structure and Toxicity

Fyodor V. Chorkina (Editor)
Andrey I. Karataev (Editor)

Series: Biochemistry Research Trends, Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The sulfur amino acid, cysteine, plays an essential role in maintaining cellular redox potential and is a key constituent of the antioxidant, glutathione. Cysteine is highly reactive and readily oxidizes to the disulfide form, cystine, producing oxygen radicals as a by-product. In this book, the authors present current research in the study of the biosynthesis, chemical structure and toxicity of cysteine. Topics include cysteine biosynthesis in plants; the structural and functional role of cysteine residues; new cysteine synthesis pathways and their applications; implications for cysteine neurotoxicity; and the protecting groups used to cage cysteine and their applications in biochemical experiments are reviewed. (Imprint: Nova Biomedical )

Preface

Cysteine Biosynthesis in Plants: Essential Step in Sulfur-Metabolism
(Kevin Babilonia, Dimuth Siritunga, Department of Biology, University of Puerto RicoMayaguez, Mayaguez, Puerto Rico)

Cysteine Residues of the Yeast Pma1 H+-ATPase: Structural and Functional Role
(Valery V. Petrov, Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Region, Russia)

Toxicity of Cysteine: Towards Biopathways
(Suresh Kumar Kailasa, Hui-Fen Wu, Department of Applied Chemistry, S. V. National Institute of Technology, Surat, India and others)

L-Cysteine Comparison to L-Methionine: Is Readily Substituted Sulphur Atom by Selenium Related to More Abundant Occurrence of Selenoamino Añid in Mushroom Culture?
(Alexei N. Pankratov, Olga M. Tsivileva, Nikolay A. Bychkov, Division of Analytical Chemistry and Chemical Ecology, Institute of Chemistry, N.G. Chernyshevskii Saratov State University, Saratov, Russia, and others)

Biosynthesis of Cysteine
(Kazuhiko Ishikawa, Koshiki Mino, National Institute of Advanced Indrustrial Science and Technology (AIST), Biomass Technology Research Center, Kagamiyama, Higashi-hiroshima, Hiroshima, Japan, and others)

Astrocytes and the Regulation of Cerebral Cysteine/Cystine Redox Potential: Implications for Cysteine Neurotoxicity
(Gethin J. McBean, UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland)

Caging Groups for Cysteine: Synthesis and Biological Applications
(Daniel Abate-Pella, Mark D. Distefano, Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA)

Index

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