Cyclodextrins: Synthesis, Chemical Applications and Role in Drug Delivery


Francis G. Ramirez (Editor)

Series: Biochemistry and Molecular Biology in the Post Genomic Era
BISAC: SCI007000

Cyclodextrins (CDs) are capable of interacting with a large variety of guest molecules to form inclusion complexes. The authors of the chapters that form this book discuss the development of ion-selective electrodes based on selected cyclodextrins and their derivatives as selective ionophores for various drugs and their applications in pharmaceutical research; the wide range of applications of CDs in biomedical electrochemistry, focusing both on their behavior in solutions and embedded in thin films formed at the electrode surface; the general features of CDs and the progress done so far in the field of microencapsulation of pesticides in CDs; cyclodextrins as encapsulating agents for bioactive plant molecules in the pharmaceutical field; the effect of cyclodextrins on the photodegradation profile of drugs when they are used in drug formulations; applications of cyclodextrins in stabilizing or solubilizing ingredients of pharmaceutical relevance used in the food industry (commonly called nutraceuticals); the use and importance of cyclodextrins in the pharmaceutical industry; the main aspects of the crystal structures of the dimeric β-CD inclusion complexes; the influence of biologically active inorganic ions on complex formation of cyclodextrins with some aromatic carboxylic acids possessing pharmacological and biological activity; the importance of detailed characterization of the composition of substituted CDs by the example of sulfobutylether cyclodextrins; the several crystal structures of dye inclusion complexes using cyclodextrin, the preparation of DISC (dye inclusion single crystal); the structural details about the dye inclusion complex analyzed by X-ray and the properties of porphyrin DISC.
(Imprint: Nova)




Table of Contents


Chapter 1
Chemical Application of Cyclodextrins in Potentiometry – Review
(Joanna Lenik, Faculty of Chemistry, Maria Curie-Skłodowska University, 5 M. Curie-Skłodowskiej Square, Lublin, Poland)

Chapter 2
Applications of Cyclodextrins in Biomedical Electrochemistry
(Luminița Fritea, Mihaela Tertiş, Robert Săndulescu, Analytical Chemistry Department,”Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania)

Chapter 3
Cyclodextrins: A Valuable Resource to Attain Environmental Sustainability
(Carlos Fernandes, Igor Encarnação, André Fonseca, Jorge Garrido, Fernanda Borges, E. Manuela Garrido, CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal, and others)

Chapter 4
Cyclodextrins Supramolecular Complexes with Botanical Compounds
(Maria Camilla Bergonzi and Anna Rita Bilia, Department of Chemistry, Building ex Pharmaceutical Sciences, University of Florence, Florence, Italy)

Chapter 5
Effect of Inclusion Complexation with Cyclodextrins on the Photodegradation Profile of Drugs
(Snezana Agatonovic-Kustrin, David W. Morton and Kailash C. Petkar, The School of Pharmacy and Applied Science, La Trobe Institute of Molecular Sciences, La Trobe University, Bendigo, Victoria, Australia, and others)

Chapter 6
Cyclodextrin Inclusion of Nutraceuticals, from the Bench to your Table
(Ana Bárbara Pereira, Susana S. Braga, Department of Chemistry, QOPNA – Organic Chemistry, Natural and Agro-Food Products Research Unit, University of Aveiro, Aveiro, Portugal)

Chapter 7
The Importance of Inclusion Complexes with Cyclodextrins in Pharmacy
(Vesna D. Nikolic, Agnes J. Kapor, Ljubisa B. Nikolic, Ivan M. Savic, and Ivana M. Savic-Gajic, Faculty of Technology, University of Nis, Leskovac, Serbia, and others)

Chapter 8
ß-Cyclodextrin Dimeric Inclusion Complexes: A Review of Some Crystal Structure Aspects
(Dimitris Mentzafos and Kostas Bethanis, Agricultural University of Athens, Department of Biotechnology, Physics Laboratory, Athens, Greece)

Chapter 9
Salt Effects on the Inclusion Complex Formation of Cyclodextrins with some Biologically Active Aromatic Carboxylic Acids
(Irina V. Terekhova, G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, Ivanovo, Russian Federation)

Chapter 10
Sulfobutylether-Cyclodextrins: Structure, Degree of Substitution and Functional Performance
(István Puskás, Erzsébet Varga, Kata Tuza, Julianna Szemán, Éva Fenyvesi, Tamás Sohajda, Lajos Szente, CycloLab Cyclodextrin Research & Development Laboratory Ltd., Budapest, Hungary)

Chapter 11
Dye Inclusion Single Crystals; Preparations, Structures and Functions
(Youichi Tsuchiya, Institute of Systems, Information Technologies and Nanotechnologies (ISIT), Fukuoka industry-academia Symphonicity (FiaS), Kyudaishinmachi, Nishi-ku, Fukuoka, Japan)



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