Current Topics in Atherosclerosis Research


Yong J. Geng
University of Texas Health Science Center at Houston

Atherosclerosis is a degenerative condition in which arteries build up deposits called plaques (atheromas) which consist of lipids (mainly cholesterol), connective tissue and smooth muscle cells originating from the arterial wall. Plaques develop quietly over a period of years and are unnoticeable until there is an interruption in the normal flow of blood. Plaques may partially or totally block the blood’s flow through an artery. Two things that can happen where plaques occur are: bleeding (hemorrhage) into the plaque; and formation of a blood clot (thrombus) on the plaque’s surface. Atherosclerosis affects large and medium-sized arteries. The type of artery and where the plaque develops varies with each person. Atherosclerosis research has witnessed startling progress in recent years, partially due to new drugs as well as to new breakthroughs in molecular medicine

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Table of Contents

Table of Contents

Preface Yong-Jian Geng, MD, PhD

Introduction: Yong-Jian Geng, MD, PhD

Chapter 1 Atherosclerotic Vulnerable Plaques: Pathophysiology and Detection. Mohammad Madjid, MD, Silvio Litovsky, MD, James T. Willerson, MD, S. Ward Casscells, MD

Chapter 2 Vascular Cell Apoptosis in Atherosclerotic Plaque Development.
Yong-Jian Geng, MD, PhD

Chapter 3 Inflammatory Vascular Markers in Atherosclerosis.
Paolo Calabro, MD, Edward T. Yeh, MD, PhD

Chapter 4 Nitric Oxide Biology in Atherosclerosis.
Ka Bian, MD, Ferid Murad, MD, PhD

Chapter 5 Thrombogenesis and Anti-thrombogenesis in Atherosclerosis Mediated by Prostanoids through the Cyclooxygenase Pathway.
Ke H. Ruan, MD, PhD

Chapter 6 Atherosclerosis in Patients with Chronic Kidney Disease.
Bruce C. Kone, MD, Diana Jalal, MD

Chapter 7 Ion channels in Atherosclerotic Arteries.
Shigeru Morishima, MD, PhD and Yong-Jian Geng, MD, PhD

Chapter 8 Stem Cells in Atherosclerosis.
Yong-Jian Geng, MD, PhD and Rosalinda Madonna, MD, PhD

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