Curcumin: Clinical Uses, Health Effects and Potential Complications

Valeria Martin (Editor)

Series: New Developments in Medical Research
BISAC: MED008000

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Curcumin is a natural product with polyphenolic structure. It is used in therapeutic remedies alone or in combination with other natural substances. Many researchers are investigating it because of its biological activities such as: anti-inflammatory, anti-cancer, anti-protozoal, anti-viral, anti-bacterial and has been found to be effective for treatment of Alzheimer, depression, headaches, fibromyalgia, leprosy, fever, menstrual problems, water retention, worms and kidney problems etc. It is an active ingredient in dietary spice, turmeric. It has reactive functional groups: a diketone moiety and two phenolic groups.

Despite its unique biological activities, it suffers from some shortcomings which include: gastrointestinal problems, poor bioavailability due to its poor absorption, short half-life, poor solubility in aqueous solutions, rapid systemic elimination and antithrombotic activity which can interfere with blood clotting. The first chapter of this book reviews the different delivery systems used for incorporation of curcumin and its derivatives, release kinetics and up to date in vivo results. Chapter two discusses curcumin nano and microencapsulation and its implications on clinical uses.

Chapter three studies the epigenetic changes induced by curcumin and its congeners and the potential of utilizing these changes in the treatment of different diseases. The last two chapters examine the effects of curcumin in human nasal epithelial cells; and differential absorption of curcuminoids between free and liposomed curcumin formulations.
(Imprint: Nova)

Preface
pp. vii-x

Chapter 1
An Overview of Nano-Based Formulations of Curcumin and its Derivatives
(B. A. Aderibigbe, T. Naki and A. Mugogodi, Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape)
pp. 1-24

Chapter 2
Curcumin Nano and Microencapsulation and its Implications on Clinical Uses
(Jéssica T. P. Silva, Anderson C. da Silva, Bruno A. da Rocha, Lívia Bracht, Ciomar A. B. Amado, Fernanda V. Leimann, Odinei H. Gonçalves, Post-Graduation Program of Food Technology - Federal University of Technology – Paraná, Via Rosalina Maria dos Santos, Campo Mourão – PR, Brazil, and others)
pp. 25-64

Chapter 3
The Effects of Curcumin in Human Nasal Epithelial Cells
(Kenichi Takano, Kazufumi Obata, Tetsuo Himi and Takashi Kojima, Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan, and others)
pp. 65-82

Chapter 4
Epigenetic Modifications Induced by Curcumin and its Congeners
(Tamer E. Fandy, Department of Pharmaceutical Sciences, Albany College of Pharmacy (Vermont campus), Colchester, VT, USA)
pp. 83-98

Chapter 5
Differential Absorption of Curcuminoids between Free and Liposomed Curcumin Formulations
(Enrique Barrajón Catalán, Lorena Funes, María Herranz-López, Isabel González-Álvarez, Marival Bermejo and Vicente Micol, Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández, Alicante, Spain, and others)
pp. 99-110

Index
pp. 111-122

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