Crohn’s Disease: Classification, Diagnosis and Treatment Options


Jean Guy LeBlanc and Alejandra de Moreno de LeBlanc (Editors)
Centro de Referencia para Lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Argentina

Series: Digestive Diseases – Research and Clinical Developments
BISAC: HEA039010

Crohn’s Disease (CD) is one of the most important chronic inflammatory bowel diseases (IBD) that can affect the whole gastrointestinal tract from mouth to anus, and whose inflammation extends through all layers of the gut wall. Treatments normally consist of controlling the symptoms, maintaining remission and preventing relapse. Despite many years of study, the exact etiology and pathogenesis of this disorder still remains unclear. However, great advances have been made in the last decades that have provided insights into the complex, multi-factorial processes and mechanisms that can result in chronic intestinal inflammation such as those present in Crohn’s Disease.

This book will describe etiological factors (host-microbiome interactions, nutrition, immune system, genetic and life-styles), novel and conventional diagnostic tools (magnetic resonance enterography, multidetector contrast-enhanced computed tomography, small bowel magnetic resonance imaging, intestinal ultrasound, endoscopy and histology), complications (musculo-skeletal, and intra-abdominal) along with conventional and novel treatment options (strictureplasty techniques, use of biological agents, probiotic microorganisms and genetically engineered lactic acid bacteria) for CD and other IBD. This new book is a compilation of topics that have been written by experts from all over the world (Argentina, Australia, Brazil, Chile, France, Hungary, Italy, Spain, United Kingdom and the United States of America) who work in medical, clinical or research settings offering different viewpoints on the most up-to-date information currently available on Crohn’s Disease. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents



Chapter 1. Current Knowledge in Inflammatory Bowel Diseases Immunopathogenesis
(Natalia Salgado, David Díaz-Jiménez, Marjorie De La Fuente, Rodrigo Quera and Marcela A. Hermoso, Especialist Training Program, Medicine Graduate School, Faculty of Medicine, Universidad de Chile, Chile, and others)
<a href=”” target=”_blank” rel=”noopener”>Free Download Available</a>

Chapter 2. Crohn´s Disease within the Hologenome Paradigm
(Emiliano Salvucci, S.M. de Tucumán, Argentina)

Chapter 3. Nutrition and Inflammatory Bowel Disease
(Karla Bascuñán, David Díaz-Jiménez, Rodrigo Quera and Marcela A. Hermosa, Laboratory of Innate Immunity, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Chile, and others)
<a href=”” target=”_blank” rel=”noopener”>Free Download Available</a>

Chapter 4. Pathogenesis of Crohn’s Disease: The Role of Lifestyle
(AM El-Tawil, Department of Surgery, University Hospital Birmingham,
Birmingham, UK)

Chapter 5. Ibd3 Genomic Loci in Crohn´s Disease: Immunogenetics of HLA and NKG2D Ligands (MICA) Genes
(Ruth López, José A. Campillo, Pedro Martinez, Gema Salgado, Francisco Boix, Rosa Moya, Ana Garcia, Alfredo Minguela, Rocío Álvarez and Manuel Muro, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Immunology Service, University Hospital Virgen Arrixaca, Murcia, Spain)


Chapter 6. Diagnostic and Assessment Issues in Crohn’s Disease
(Dan Hilton, Kaleb Marr, Amy Sandford, Johan Van den Bogaerde and Dario Sorrentino, University of Queensland and Sunshine Coast Clinical School, Australia, and others)

Chapter 7. Magnetic Resonance Enterography. Review of the Technique and Assessment of Crohn’s Disease: Spectrum of Findings and Disease Activity
(Luis Herraiz Hidalgo, Raquel Cano Alonso, Ana Bermejo Moríñigo and Vicente Martinez de Vega Fernández, Departamento de Diagnóstico por la Imagen, Hospital Universitario Quirón Madrid, Spain, and others)

Chapter 8. Cross-Sectional Imaging of High- and Low-Grade Bowel Obstruction from Crohn’s Disease using Multidetector CT and MRI, Including Enteroclysis and Enterography Techniques
(Chiara Villa, Massimo Tonolini, Alessandro Campari, Anna Ravelli, Roberto Bianco and Gianpaolo Cornalba, Department of Radiology, “Luigi Sacco” University Hospital, Milan, Italy, and others)

Chapter 9. Musculo-Skeletal Complications of Crohn’s Disease: Spondylitis, Sacroiliitis and Peripheral Arthritis
(Marco Antivalle, Michele Battellino, Alberto Batticciotto, Maria Chiara Ditto, Valentina Varisco and Piercarlo Sarzi Puttini, Rheumatology Unit, L. Sacco University Hospital, Milano, Italy)

Chapter 10. Intra-abdominal Complications of Fistulizing Crohn’s Disease: Spectrum of Cross-Sectional Imaging Findings
(Alessandro Campari, Anna Ravelli, Massimo Tonolini, Chiara Villa, Roberto Bianco and Gianpaolo Cornalba, Department of Diagnostic and Interventional Radiology, San Paolo Hospital, Milan University, Milan, Italy, and others)


Chapter 11. A Review of Strictureplasty Techniques in Crohn’s Disease: Types, Indications and Comparisons
(Ronald Ambe, Lorna Campbell and Burt Cagir, Department of Surgery, Sacred Heart Hospital, Allentown, PA, USA, and others)

Chapter 12. Biological Agents Therapy in Crohn’s Disease
(Anna Bellizzi, Elena Anzivino, Donatella Maria Rodio, Daniela Fioriti, Monica Mischitelli, Fernanda Chiarini and Valeria Pietropaolo, Department of Health Sciences and Infectious Diseases,
“Sapienza” University, Rome, Italy, and others)

Chapter 13. Prediction of Response, Dose Intensification and Loss of Response to Anti TNF Therapy in Inflammatory Bowel Diseases
(Pal Miheller and Peter Laszlo Lakatos, Semmelweis University,
Budapest, Hungary)

Chapter 14. Use of Probiotics in the Treatment of Crohn’s Disease
(Silvina del Carmen, Jean Guy LeBlanc and Alejandra de Moreno de LeBlanc, Centro de Referencia para Lactobacilos (CERELA-CONICET),
San Miguel de Tucumán, Argentina)

Chapter 15. Use of Genetically Engineered Lactic Acid Bacteria for the Treatment of Crohn’s Disease
(Jean Guy LeBlanc, Silvina del Carmen, Philippe Langella, Luis Bermudez-Humaran, Fernanda Alvarenga Lima, Meritxell Zurita Turk, Daniela Santos Pontes, Anderson Miyoshi, Vasco Azevedo and Alejandra de Moreno de LeBlanc, Centro de Referencia para Lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Argentina, and others)


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