CRISPR: Advances in Research and Applications

Xin Wang (Editor)
Institute of Biomedical Sciences, East China Normal University, Shanghai, China

Series: Biochemistry Research Trends
BISAC: MED008000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Genome editing using CRISPR has been identified as one breakthrough technology in recent research. Today, it is difficult to open a journal or a newspaper without reading about the application of CRISPR gene editing technology to basic research, public health, therapeutics or diagnostics. Although some problems of CRISPR remain to be solved, such as bio-safety and ethical issues, it may change people’s futures. This book is to meet the needs of basic molecular biochemists, pharmacologists, medical students, clinical practitioners and scientists, as well as a broad spectrum of readers who wish to understand the advances in research and applications of CRISPR. The contributing authors are basic scientists as well as students who major in biochemistry and pharmacology. The book presents the current research in the CRISPR model, focusing on its advances and applications. Topics discussed in this compilation include: Targeting of hepatic diseases using CRISPR; applications and advances of CRISPR in animal models; gene targeting on the Cyp2c Locus in rats via CRISPR; applications of CRISPR for therapy in human genetic diseases; utilization of CRISPR in gene function and drug target validation; applications of CRISPR in plant genome editing; and genome editing on human embryos using CRISPR.

Preface

Chapter 1. Advances in Research and Applications of CRISPR
Xin Wang (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China)

Chapter 2. CRISPR/Cas Genome Editing: Targeting Hepatic Diseases
Xuan Qin and Xin Wang (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China)

Chapter 3. Applications and Advances of CRISPR/Cas9, a Versatile Tool for Genome Editing in Animal Models
Jian Lu and Xin Wang (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China)

Chapter 4. Gene Targeting on Cyp2c Locus in Rats Using the CRISPR/Cas9 System
Jian Lu, Mingyao Liu and Xin Wang (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China)

Chapter 5. Applications of CRISPR/Cas9 for Therapy in Human Genetic Diseases
Lei Zhang and Xin Wang (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China)

Chapter 6. Utilization of CRISPR in Gene Function and Drug Target Validation
Xuan Qin and Xin Wang (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China)

Chapter 7. Applications of CRISPR/Cas9 in Plant Genome Editing
Ang Chen and Xin Wang (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China)

Chapter 8. Genome Editing on Human Embryos by CRISPR is Attractive but Controversial
Xuan Qin and Xin Wang (Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China)

Index

This book is to meet the needs of basic molecular biochemists, pharmacologists, medical students, clinical practitioners and scientists, as well as a broad spectrum of readers who wish to understand the advances in research and applications of CRISPR.

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