Creatine: Biosynthesis, Therapeutic Uses and Physiological Effects of Supplementation


Fernando D’Cruz (Editor)
Victor Ribeiro (Editor)

Series: Biochemistry Research Trends
BISAC: SCI007000

Creatine is an organic acid that contributes to the energy supply to the skeletal muscle. The basic substrates for creatine biosynthesis in the human body are semi-essential amino acids L-arginine, glycine and methionine. In this book, the authors discuss the biosynthesis, therapeutic uses and physiological effects of creatine supplementation.

Topics include the role of creatine in the pathophysiology of depression and the possible mechanisms underlying its antidepressant effect, creatine treatment and positive effects on muscle performance, muscle mass gain, and the persistence and improvement of the quality of life in patients with chronic diseases; muscle ergogenic effects of creatine supplementation in resistance exercise training; experimental evidence that creatine supplementation during pregnancy is protective for the neonate; and creatine metabolism and role in sports physiology. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


The Role of Creatine in the Pathophysiology of Depression and the Possible Mechanisms Underlying its Antidepressant Effect
(Mauricio P. Cunha, Francis L. Pazini, Ágatha Oliveira, Ana Lúcia S. Rodrigues, Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil)

Therapeutic Uses of Creatine: New Possibilities
(Martina Antošová, Jana Plevkova, Departments of Physiology and Pathophysiology, Comenius University Jessenius Faculty of Medicine, Malá Hora, Martin, Slovakia)

Muscle Ergogenic Effects of Creatine Supplementation in Resistance Exercise Training
(Roberto Carlos Burini, Edilson Serpeloni Cyrino, Centre for Nutrition and Exercise Metabolism, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu (SP), Brazil, and others)

Experimental Evidence that Creatine Supplementation during Pregnancy is Protective for the Neonate
(David W. Walker, Hayley Dickinson, Stacey Ellery, Domenic LaRosa, Zoe Ireland, Syed Baharom, Richard Harding, Rod Snow, The Ritchie Centre, Monash Institute for Medical Research, Clayton, Melbourne, Australia, and others)

Creatine: Metabolism and Role in Sports Physiology
(Ayed Ikram Bezrati-Ben, Fehmi Nasrallah, Raouf Hammami, Karim Chamari, Moncef Feki, Naziha Kaabachi, Laboratory of Biochemistry, Rabta Hospital, Tunisia, and others)


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