Coronavirus Disease: From Molecular to Clinical Perspectives

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Yildiz Dincer (Editor) – Istanbul University-Cerrahpasa

Series: Public Health in the 21st Century

BISAC: MED078000

The world is experiencing an unprecedented challenge due to the coronavirus disease (COVID-19) pandemic. In December 2019, a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of a cluster of pneumonia cases in Wuhan, a city in the Hubei province of China. It rapidly spread, resulting in an outbreak of COVID-19. Although the majority of the infected individuals exhibit mild to moderate respiratory illness and recover without requiring special treatment, older people and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer may rapidly progress to acute respiratory distress syndrome, septic shock, coagulation disorders, multi-organ failure, and death. The course of COVID-19 is usually mild in children. However, in rare cases, children can be severely affected, and clinical manifestations may differ from adults. Some children present the multisystem inflammatory syndrome that is similar to incomplete Kawasaki disease or toxic shock syndrome. There is no specific treatment and vaccine for COVID-19. Due to the high infectivity rate of COVID-19, the unexpected and rapid influx of large numbers of patients, especially patients who need intensive care, has caused great pressure on health care systems worldwide. The worldwide spread of COVID-19 caused fear, anxiety, depression, panic attacks, and a general decrease in overall wellbeing in the population.  Healthcare professionals who occupy the front line during pandemics are at increased risk concerning their physical and mental health. The outbreak of COVID-19 negatively affected all aspects of life including education, trade, and tourism. Our knowledge of this novel virus is limited. However, many ongoing clinical trials are evaluating potential treatments and vaccines. A better understanding of the pathogenesis of COVID-19 will provide important insight into its management and reduce the mortality rate. Based on the latest global scientific data and clinical experiences of the authors, this book gives the readers an overview of COVID-19 pathogenesis and transmission routes, current diagnostic and treatment strategies, the clinical course of the disease in children and elderly patients, the genetic background of differences in the incidence of new SARS-CoV-2 infection, the impact of the COVID-19 pandemic on patients with chronic diseases such as diabetes, cancer, cardiovascular diseases and chronic respiratory diseases, antioxidant therapy to limit tissue damage, molecular approaches in COVID-19 treatment, and vaccine studies.

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Preface

Chapter 1. Epidemiology and Pathogenesis of COVID-19
(Seda Salman Yılmaz and Gökhan Aygün)

Chapter 2. Transmission of New SARS-CoV-2 and Prevention Strategies
(Bilgul Mete, Ahmet Furkan Kurt and Gokhan Aygun)

Chapter 3. Clinical aspect of COVID-19
(Aslıhan Demirel and Fehmi Tabak)

Chapter 4. Diagnosis of COVID-19
(Mert Ahmet Kuskucu and Prof. Dr. Fehmi Tabak)

Chapter 5. Treatment Options for COVID-19 Patients
(Hakan Yavuzer and Pınar Arman)

Chapter 6.  Intensive Care Management of COVID-19 Patients
(Olcay Dilken and Yalim Dikmen)

Chapter 7.  Anatomical Basis of COVID-19 Disease
(Mehmet Üzel and Ö. Alp Taştan)

Chapter 8. Genetic background of differences in the incidence of new SARS-CoV-2 infection
(R.Dilhan Kuru and  Ilhan Onaran

Chapter 9. The Clinical Course of COVID-19 in Elderly Patients
(Hakan Yavuzer and Rabia Bag Soytas)

Chapter 10. SARS COV-2 in Pediatric Patients: Hematological Face of the Disease
(Tulin Tiraje Celkan and Ayse Gonca Kacar)

Chapter 11. COVID-19 and Ophthalmology
(Ceyhun Arici and Burak Mergen)

Chapter 12. The Impact of the COVID-19 Pandemic on Patients with Diabetes
(Zeynep Mine Coskun  and  Sema Bolkent)

Chapter 13. The Impact of the COVID-19 Pandemic on Patients with Chronic Respiratory Diseases
(Buket Caliskaner Ozturk)

Chapter 14. The Impact of the COVID-19 Pandemic on Patients with Cardiovascular Diseases
(Serap Yavuzer and Veysel Suzan)

Chapter 15. The Impact of the COVID-19 Pandemic on Patients with Cancer
(Hande Turna)

Chapter 16. COVID-19 From General Surgery Perspective
(Selen Soylu and Serkan Teksoz)

Chapter 17. Cytokine Storm and Oxidative Stress in COVID-19
(Yildiz Dincer and Selin Yuksel)

Chapter 18. Antioxidant Agents in the Treatment of COVID-19
(Mujgan Cengiz)

Chapter 19. Vaccine Development Studies for COVID-19
(Yesim Tok and Gökhan Aygün)

Chapter 20. Molecular Approaches in COVID-19 Treatment
(Mehmet Guven and  Bahadir Batar)

Index

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