Coronary Artery Restenosis: Causes, Treatment and Clinical Outcomes


Amir S. Lotfi (Editor)
Baystate Medical Center, Tufts University School of Medicine, Division of Cardiology, MA, USA

Series: Cardiology Research and Clinical Developments
BISAC: MED010000

Percutaneous coronary intervention is the most commonly performed invasive cardiac procedure and represents a technical advance in the treatment of ischemic heart disease. Since the introduction of coronary balloon angioplasty in 1977 by Andreas Grüntzig, there has been a rapid advancement in the technique, equipment, and pharmacotherapy of treating coronary atherosclerotic disease. Prevention of coronary restenosis after successful coronary intervention continues to present therapeutic challenges. Understanding of the complex mechanism of coronary restenosis has led to improving technologies to improve clinical outcomes. This book provides the practicing cardiologists an extensive review of coronary restenosis starting by describing the overall background and pathophysiology of restenosis in Part I.

In Part II, the diagnosis of restenosis using different physiological and imaging techniques will reviewed.

In Part III, pharm logical and interventional treatment for native and saphenous vein graft restenosis will be reviewed.

In Part IV, Future strategies of treating restenosis will be reviewed.

With these chapters discussing the current understanding on the mechanism of restenosis, clinical outcomes, different modalities of diagnosing restenosis, treatment of restenosis, and future therapies of treating restenosis, I believe this book will provide the reader with a thorough understanding of coronary restenosis, leading to better clinical decision making and patient management. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Part I. Definition, Pathophysiology, and Diagnosis

Chapter 1 – Restenosis: Historical Background and Incidence (pp. 3-16)
Justin Maroney, MD, and Lloyd W. Klein, MD (Geisinger Medical Center, Danville, PA and others)

Chapter 2 – Mechanisms of Restenosis (pp. 17-32)
B. Alkhatib, J. DeLeon and S. S. Naidu (SUNY – Stony Brook School of Medicine, Winthrop University Hospital, Mineola, NY, US)

Chapter 3 – Morphologic Patterns of In-Stent Restenosis (pp. 33-68)
Gennaro Giustino, MD, Daniele Giacoppo, MD, Jennifer Yu and Roxana Mehran, MD (Ospedale San Raffaele, Milan, Italy and others)

Chapter 4 – Coronary Restenosis: Clinical Outcomes (pp. 69-76)
Hani Kozman, MD, and Kan Liu, MD (Upstate Medical University Syracuse, NY, US and others)

Chapter 5 – Late Phase In-Stent Restenosis after Coronary Stent Implantation (pp. 77-98)
Shigenori Ito, MD, PhD (Division of Cardiology, Nagoya City East Medical Center, Japan)

Chapter 6 – Stent Sizing Without Intravascular Imaging: Impact on Restenosis (pp. 99-116)
Yohan Chacko, J. Kimberly Haladyn and Richard Lim (The University of Queensland, Brisbane, Australia and others)

Part II. Diagnosis of Restenosis —Need Something Here on Angiographic Definition and Their Diagnosis

Chapter 7 – Physiological Assessment of Coronary Restenosis (pp. 119-130)
Mauro Echavarría-Pinto, MD, Tim P. van de Hoef, MD, and Javier Escaned, MD, PhD (Cardiovascular Institute, Hospital Clínico San Carlos and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain, and others)

Chapter 8 – The Role of Intravascular Ultrasound in Understanding the Mechanism, Prevention and Management of Restenosis (pp. 131-150)
Jaya Mallidi, MD, Ali Haider, MD, and Amir Lotfi, MD (Division of Cardiology, Baystate Medical Center, Springfield, MA, US)

Chapter 9 – Optical Coherence Tomography: Current Utility and Future Potential for Management of In-Stent Restenosis (pp. 151-168)
Talla A. Rousan, MD, and Faisal Latif, MD (Department of Medicine, Cardiovascular Section, VA and others)

Chapter 10 – Coronary CTA for the Evaluation of In-Stent Restenosis (pp. 169-184)
Jaspreet Singh, MD, Amgad N. Makaryus, MD, and Avneet Singh, MD (North Shore-LIJ Health System, NuHealth, Nassau University Medical Center, East Meadow, NY, US)

Part III. Treatment of Restenosis

Chapter 11 – Pharmacotherapy of Coronary In-Stent Restenosis (pp. 187-200)
Girish R. Sabnis, MD, and Prafulla G. Kerkar, MD (Department of Cardiology, Seth GS Medical College & KEM Hospital, Mumbai, India)

Chapter 12 – Interventional Treatment of Restenosis (pp. 201-212)
Larry S. Dean, MD (University of Washington School of Medicine, WA, US)

Chapter 13 – Saphenous Vein Graft Restenosis and Management (pp. 213-236)
M. Javed Ashraf MD, and James A. Grantham MD (Truman Medical Center, and Mid America Heart Institute/Saint Luke Hospital, UMKC School of Medicine, Kansas City, MO)

Part IV: Future Strategies in the Treatment of Restenosis

Chapter 14 – Prevention of Restenosis with Stent-Based Vascular Gene Delivery: Gene Eluting Stents (pp. 239-262)
Ilia Fishbein, Michael Chorny, Ivan S. Alferiev, Richard F. Adamo and Robert J. Levy (The Children’s Hospital of Philadelphia and the University of Pennsylvania, PA, US)

Chapter 15 – Future Strategies for Preventing and Treating Coronary Restenosis (pp. 263-284)
Ehrin J. Armstrong and John C. Messenger (Division of Cardiology, University of Colorado School of Medicine, CO, US)


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