Concepts of Periodontal Regeneration and Regenerative Medicine: Mechanisms that Modulate Cells and Matrices

Mena Soory
King’s College London Dental Institute, Denmark Hill, London, UK

Series: Stem Cells – Laboratory and Clinical Research
BISAC: SCI072000

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Volume 10

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Volume 2

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Diverse technologies have emerged in recent times to streamline applications of more predictable materials and methods, in order to attain the elusive goal of periodontal regeneration. Their applications, current limitations and future directions are reviewed. In addition to grafting materials and barrier membranes to exclude epithelial downgrowth and promote mesenchymal elements, the environment of the cell is pivotal to events that follow. These include application of scaffolds, lasers, harnessing bone anabolic activity and the resolution of inflammation using cell-and gene-based protein and peptide therapy.

Recommendations embrace suitable targets for patient outcome based on clinical applications of scientific principles for more predictable and consistent results in regenerating hard and soft tissues of a functional periodontium. They must, however, stay within safety requirements and an effective cost/benefit ratio. Regenerative medicine and dentistry combine applications of molecular biology, material science, bioengineering and nanoscience in order to repair, regenerate and replace missing tissue. The author discusses these applications as well as the mechanisms that modulate cells and matrices in periodontal regeneration as well as regenerative medicine.
(Imprint: Nova Biomedical)

Preface

Chapter 1
Introduction

Chapter 2
Strategies for Periodontal Regeneration

Chapter 3
Biomarkers of Cell Differentiation and Growth Promoting Agents

Chapter 4
Periosteal Cell Sheets and Tissue Matrix

Chapter 5
Functions of Hydrogels in Tissue Regeneration

Chapter 6
Regenerative Medicine, Cell Signalling and Gene Delivery

Chapter 7
Biomechanics of Stem Cells and Their Applications

Chapter 8
Smart Biomaterials and Scaffolds

Chapter 9
The Role of Micro RNAs in Tissue Engineering

Chapter 10
3-D Printing of Tissue Regenerative Materials and Their Applications

Index

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