Comparative in Vitro Effects of Soybean Isoflavones and Resveratrol on Human Osteoblastic Cells

Arancha R. Gortázar (Editor)
Verónica Alonso (Editor)
Pedro Esbrit (Editor)
Fundación Jiménez Díaz (Capio Group), Madrid, Spain

Series: Biotechnology in Agriculture, Industry and Medicine
BISAC: SCI086000



Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Estrogen, the main factor responsible for the maintenance of bone mass in women, inhibits bone resorption and increases bone density at least in part by interacting with osteoblasts. Estrogen replacement therapy effectively prevents bone loss after menopause, but also has adverse effects. Natural plant phytoestrogens, which have structural similarity to 17β-estradiol, are of growing interest by their potential role in osteoporosis prevention and treatment. This book compares several osteoblastic effects of the soy isoflavones genistein and daidzein, two well known phytoestrogens, and resveratrol, a phenolyc phytoestrogen abundant in grapes and wine. Human osteosarcoma MG-63 cells were used in a characterized model for their nontransformed counterparts in a variety of studies on osteoblast function. (Imprint: Nova Biomedical)



Materials and Methods






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