Clopidogrel: Pharmacology, Clinical Uses and Adverse Effects

James P. Alesci (Editor)
Alexander Victorino (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED058170

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Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Clopidogrel is an oral thienopyridine derivative, used as an anti-platelet aggregation agent to inhibit blood clot formation in coronary artery disease, peripheral vascular disease and cerebrovascular disease. In this book, the authors discuss the pharmacology, clinical uses and adverse effects of clopidogrel. Topics include clopidogrel use in neurointerventional surgery; management of clopidogrel hypersensitivity; clopidogrel and gastrointestinal harm; perioperative management of clopidogrel in urological surgery; and platelet function testing to guide therapy in poor responders to clopidogrel. (Imprint: Nova Biomedical )

Preface

Clinical Review: Pharmacology of Traditional and Modern Anticoagulant and Antiplatelet Therapy
(Parth J. Parekh, Jonathan Merrell, John E. Brush, David A. Johnson, Eastern Virginia Medical School, Norfolk, VA, USA, and others)

Clopidogrel in Neurointerventional Surgery: Indications, Complications, Challenges and Methods for Monitoring Response
(S. Hassan Akbari, Matthew R. Reynolds, Christopher J. Moran, Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA, and others)

Clopidogrel Pharmacokinetic: Review of Early Studies and Novel Experimental Results
(L. Silvestro, S.N. Savu, S. Rizea Savu, I. Tarcomnicu, 3S-Pharmacological Consultation & Research GmbH, Koenigsbergerstrasse, Harpstedt, Germany, and others)
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From Mechanism to Therapeutics: Overcoming Inter-Individual Variability in Clopidogrel Therapy
(Haoming Zhang, Paul F. Hollenberg, Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI, USA)

Management of Clopidogrel Hypersensitivity
(Henry Siu, Antony Kaliyadan, Kimberly L. Campbell, David L. Fischman, Nicholas Ruggiero, Paul Walinsky, Michael P. Savage, Division of Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA)

Clopidogrel and Gastrointestinal Harm
(Parth J. Parekh, Edward C. Oldfield IV, David A. Johnson, Eastern Virginia Medical School, Norfolk, VA, USA)

Perioperative Management of Clopidogrel in Urological Surgery
(N.F. Davis, J.C. Forde, H.D. Flood, Department of Urology, University of Limerick Teaching Hospital, Limerick, Ireland)

Platelet Function Testing to Guide Therapy in Poor Responders to Clopidogrel
(Sattar Gojraty, Dmitriy N. Feldman, Division of Cardiology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA)

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