Circulating Tumor Cells (CTCs): Detection Methods, Health Impact and Emerging Clinical Challenges

Paresh Chandra Ray (Editor)
Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA

Series: Biochemistry and Molecular Biology in the Post Genomic Era
BISAC: SCI007000

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Circulating tumor cells (CTCs) are the seeds for cancer metastases development, which is responsible for >90% of cancer-related deaths. Accurate quantification of CTCs in human fluids could be an invaluable tool for understanding cancer prognosis, delivering personalized medicine to prevent metastasis and finding cancer therapy effectiveness. Although CTCs were first discovered more than 200 years ago, until now it has been a nightmare for clinical practitioners to capture and diagnose CTCs in clinical settings. Our society needs rapid, sensitive, and reliable assays to identify the CTCs from blood in order to help save millions of lives.

Due to the phenotypic EMT transition, CTCs are undetected for more than one-third of metastatic breast cancer patients in clinics. To tackle the above challenges, the first volume in Circulating Tumor Cells (CTCs): Detection Methods, Health Impact and Emerging Clinical Challenges discusses recent developments of different technologies, which have the capability to target and elucidate the phenotype heterogenity of CTCS. It contains seven chapters written by world leaders in this area, covering basic science to possible device design which can have beneficial applications in society.

This book is unique in its design and content, providing an in-depth analysis to elucidate biological mechanisms of cancer disease progression, CTC detection challenges, possible health effects and the latest research on evolving technologies which have the capability to tackle the above challenges. It describes the broad range of coverage on understanding CTCs biology from early predictors of the metastatic spread of cancer, new promising technology for CTC separation and detection in clinical environment and monitoring therapy efficacy via finding the heterogeneous nature of CTCs.

(Imprint: Nova Biomedical)

Preface
pp. vii-ix

Chapter 1
Circulating Tumor Cells: Isolation, Expansion, Characterization and Translation to Clinic
(Arutha Kulasinghe, Henri Schmidt, Chamindie Punyadeera*, The School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of Technology, Kelvin Grove, Australia)
pp. 1-18

Chapter 2
Separation and Imaging of Circulating Tumor Cells Using Hybrid Graphene Oxide Based Nanotechnology
(Sudarson Sekhar Sinha, Aruna Vangara, Avijit Pramanik, Suhash Reddy Chavva, Yongliang Shi, Stacy Jones, Jasmine Burrell, Craig Hawker and Paresh C Ray, Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi, USA, and others)
pp. 19-46

Chapter 3
Capture and Detection of Circulating Tumor Cells with Magnetic-Plasmonic Hybrid Nanoparticles
(Saheel Bhana and Xiaohua Huang, Department of Chemistry, University of Memphis, Memphis, TN, USA)
pp. 47-64

Chapter 4
Implications of Nanotechnology for CD13 Receptor Based Tumor Targeting
(Madhu Gupta, Vikas Sharma, Shri Rawatpura Sarkar institute of Pharmacy, Datia, M.P., India)
pp. 65-88

Chapter 5
Marker-Free Isolation of CTCs using Microfabricated Platforms
(Florina Silvia Iliescu, Igor Cima, Doina Dumitrescu-Ionescu and Ciprian Iliescu, Republic Polytechnic Singapore, Institute of Bioengineering and Nanotechnology and Singapore and University of Medicine and Pharmacy, Bucharest, Romania, and others)
pp. 89-118

Chapter 6
Circulating Tumor Cells in Early Breast Cancer: Recent Advances in our Understanding of Minimal Residual Disease
(Malgorzata Banys-Paluchowski, Natalia Krawczyk, Tanja Fehm, Department of Gynecology and Obstetrics, Heinrich-Heine University Duesseldorf, Moorenstr, Duesseldorf, Germany, and others)
pp. 119-130

Chapter 7
Liposome Nanovehicles for Tumor Cell Diagnosis and Treatment
(R. A. Crouch and P. C. Ray, Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA)
pp. 131-160

About the Editor
pp. 161

Index
pp. 163-171

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