Ciprofloxacin: Biosynthesis, Applications, and Adverse Effects

Mohamed Said Attia (Editor)
Ain-Shams University, Cairo, Egypt

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

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This book is one of the most important books in this area because it is devoted to special characteristics of an important antibiotic (Ciprofluoxacin). It presents the new ways to enhance the bioavailability of ciprofluoxacin in the human body to increase its efficacy in disease treatments, such as preparation of solid forms of ciprofluoxacin, including multi-component systems to overcome their biopharmaceutical restrictions in ciprofluoxacin with amino acids and polymers to improve solubility and/or permeabilty, and different cocrystals and salts such as hippuric, maleic, barbituric, 4-hydroxybenzoic, aspartic, glutamic, succinic, maleic, adipic, salicylic, lactic and phosphoric and metal complexes of aluminum, magnesium, zinc, iron (III), bismuth, copper, cadmium and cobalt, which are recognized as safe compounds. Furthermore, concerning ciprofloxacin-silica/hydroxyapatite nanoparticles to deliver ciprofloxacin, besides their bactericidal efficacy, these systems are promising candidates for bone infection treatment in which the synthesis of silica with calcium phosphate in situ, which is a mineral present in large amounts in bone tissue, can offer interesting aspects to an improved biological activity of these materials.

This book also describes the bacterial resistance of ciprofloxacin, usually mediated by mutations in bacterial enzymes (gyrA, gyrB), topoisomerase IV (par C and par E), as well as by an active flow along the lateral outer membrane protein modification and how to overcome them. This book also presents the methods to evaluate ciprofoxacin in real samples such as a regression model that can help predict and calculate the individual dose of ciprofloxacin for patients with foot infections and the fluorometric method by using lanthanide Tb3+ and Eu3+ ions as well as sensitive and selective detection of this drug in the wastewater, which is considered an important environmental assessment.

Preface

Chapter 1. The Challenge of Improving the Bioavailability of Ciprofloxacin by Supramolecular Engineering
(Graciela Pinto Vitorino and María Rosa Mazzieri, Química Medicinal, Dpto. de Farmacia, Facultad de Ciencias Naturales y Ciencias de la Salud, Universidad Nacional de la Patagonia San Juan Bosco, Comodoro Rivadavia, Chubut, Argentina, and others)

Chapter 2. Ciprofloxacin-Silica/Hydroxyapatite Nanoparticles: Release Profile, in Vitro Biocompatibility, Bactericidal Efficiency and Cytocompatibility Studies
(Gracielle Ferreira Andrade, PhD, and Edésia Martins Barros de Sousa, PhD, Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, MG, Brazil_

Chapter 3. Distribution of Ciprofloxacin in the Peripheries
(Janis Vella, Kevin Cassar, Lilian M. Azzopardi, Anthony Serracino-Inglott and Godfrey LaFerla, Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta)

Chapter 4. Ciprofloxacin and Bacterial Pathogens: Correlation to Microbial Resistance
(Neveen M. Saleh, PhD, Mohamed M. Abd-Almouty, PhD, and Mona I. Mabrouk, PhD, Department of Microbiology, National Organization for Drug Control and Research, Giza, Egypt)

Chapter 5. Methods of Analysis, New Applications and Common Adverse Effects of Some Fluoroquinolones
(Vania N. Maslarska, PhD, Stanislav R. Bozhanov, PhD, and Magdalena S. Kondeva, PhD, Department of Chemistry,Faculty of Pharmacy, Medical University-Sofia, Bulgaria, and others)

Chapter 6. Ciprofloxacin: Analytical Methods of Analysis for Monitoring It in the Environment
(Lucas Moreira Silva, Marcos Vinicius Foguel and Maria Del Pilar Taboada Sotomayor, Instituto de Química - Departamento de Química Analítica, Universidade Estadual Paulista “Júlio Mesquita Filho” - UNESP , Araraquara, São Paulo)

Chapter 7. Fluorescence Detection of Ciprofloxacin
(Subhankar Singha, Department of Chemistry, School of Molecular Science (BK21PLUS), Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea)

About the Editor

Index

Audience: For scientists, doctors, and researchers in pharmaceutical institutes

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