Chronocardiology and Cardiac Research


Krasimira Hristova (Editor)
National Heart Institute, Sofia, Bulgaria

Jan Fedacko (Editor)
Department of Internal Medicine, PJ Safaric University, Kosice, Slovakia

Germaine Cornelissen (Editor)
Halberg Chronobiology Center, University of Minnesota, Medical School, Minneapolis, USA

Ram B. Singh (Editor)
Halberg Hospital and Research Institute, Moradabad, India
The Tsim Tsoum Institute, Krakow, Poland

Series: Cardiology Research and Clinical Developments
BISAC: MED010000

Chronocardiology and Cardiac Research bring evidence to the public domain about the role of time in cardiovascular function and dysfunction that results in a number of cardiovascular diseases. The book is divided into three parts and covers the subjects extensively.

Chronocardiology is not new to cardiologists, but it needs to be introduced to mainstream medicine, which is the main purpose of the editors of this volume. (Imprint: Nova Biomedical)



Table of Contents



Chapter 1. Travels with Franz Halberg
Othild Schwartzkopff and Germaine Cornelissen

Chapter 2. Franz Halberg, the Father of Chronobiology and Chronomics
Germaine Cornelissen and Ram B Singh

Chapter 3. Evolutionary Aspects of Circadian Rhythm and Neurocardiovascular Dysfunction
RB Singh, Kuniaki Otsuka, Daniel Pella, Jan Fedacko, Viola Michirova, Branislav Milovanovic, Krasimira Hristova, DW Wilson, and Hilton Chaves

Chapter 4. Extended Consensus on Guidelines for Assessment of Risk and Management of Hypertension: A Scientific Statement of The International College of Cardiology – Thank You, Dr. Franz Halberg
Ram B Singh, Krasimira Hristova, Daniel Pella, Jan Fedacko, Adarsh Kumar, Hilton Chaves, Ratindra Nath Mondal, Branislav Milovanovic, Germaine Cornelissen, Othild Schwartzkopff, Franz Halberg, and DW Wilson

Chapter 5. Effect of Examination on the Circadian Structure of ECG Parameters
Lyazzat Gumarova, Franz Halberg, and Germaine Cornelissen

Chapter 6. Studies on Circadian Pattern of Blood Pressure in Normotensive Pregnant Women and Preeclampsia. In Memory of Late Professor Franz Halberg, Father of Chronobiology
RK Singh, NS Verma, Neelam Barnwal, HP Gupta, Urmila Singh, Seema Mehrotra, Ranjana Singh, and RB Singh

Chapter 7. Mitochondrial Cardiomyopathy and Coenzyme Q10
A. Gvozdjáková, M. Mikulecký, FL. Crane, J. Kucharská, G. Cornelissen, A. Kumar, P. Palacka, and RB. Singh

Chapter 8. Circadian Cardiomyocyte Function and Cardiomycyte Circadian Clock
NS Verma, RK Singh, RB Singh, Jan Fedacko, Krasimira Hristova, Anna Gvozdjáková, Branislav Milovanovic, Toru Takahashi, DW Wilson, and NS Dhalla

Chapter 9. Mathematical Model of Cardiovascular Disease Risk Based on Vascular Variability Disorders
J. Siegelova, J. Dusek, K. Otsuka, and G. Cornelissen

Chapter 10. Echocardiographic Study of Circadian Myocardial Function among Clinically Healthy Subjects
Krasimira Hristova, Germaine Cornelissen, Jan Fedacko, and RB Singh

Chapter 11. Pre-Surgical and Post-surgical Alterations of Arterial Blood Pressure Circadian Rhythm
GS Katinas, Yu S Astakhov, SM Sedov, SM Yashin, SM Chibisov, SA Shastun, S Yu Astakhov, IB Boldyreva, AG Gromyko, TB Merkuryeva, DM Nefedova, DA Smirnov, and EV Mitina

Chapter 12. Timing of Statin Therapy May Eliminate its Toxicity and Increase its Bioactivity, Said Professor Halberg, The Lord of Time
Teodora Handjieva-Darlenska, Ram B Singh, Krasimira Hristova, Brainislav Milovanovic, Jan Fedacko, Sergey Chibisov, Sergey Shastun, Vicky Beeharry, Svetosslav Handjievi, and Chee Jeong Kim


Chapter 13. Antiplatelet Therapy in Heart Failure
Jan Fedacko, Ram B. Singh, Teodora Handjiev Darlenska, Krasimira Hristova, Daniel Pella, and Hilton Chaves

Chapter 14. Sofia Declaration for Prevention of Cardiovascular Diseases and Type 2 Diabetes Mellitus: A Scientific Statement of the International College of Cardiology and International College of Nutrition
Krasimira Hristova, Daniel Pella, Ram B. Singh, Borislav D. Dimitrov, Hilton Chaves, Lekh Juneja, Tapan K. Basu, Lech Ozimek, Amrat K. Singh, Shanti S. Rastogi, Toru Takahashi, Douglas W. Wilson, Fabien De Meester, Sukhinder Cheema, Branislav Milovanovic, Harpal S. Buttar, Jan Fedacko, Ivo Petrov, Svetoslav Handjiev, Agnieszka Wilczynska, Manohar L. Garg, Ivy Shiue, and RK Singh

Chapter 15. Validity of Verbal Autopsy Questionnaire for Assessment of Causes of Death among Patients with Hypertension in Bangladesh
Ratindra Nath Mondal, Md. Ashraful Haque, Shah Md. Sarwer Jahan, Abul Kalam Azad, Md. Mahfuzer Rahman, Moni Rani, B. D. Bidhu, A.K.M. Shaeheduzzaman, Md. Zakir Hossain, Md. Kumruzzaman Sarker, Amaresh Chandra Shaha, Ram B. Singh, Md. Shafiul Alam, Md. Noor Islam, and Devendra Nath Sarker

Chapter 16. Gender-Specific Issues in Coronary Artery Disease
Adarsh Kumar, Harharpreet Kaur, R. B. Singh, Germaine Cornelissen-Guilaume, and Ankita Attri

Chapter 17. Peripartum Cardiomyopathy
N.S. Neki, Ranjana Singh, Viola Vargova, and Viola Mechirova

Chapter 18. Some Pitalls in Testing Antiatherogenic Agents in Cell Cultures
Sergei V. Jargin and Douglas W. Wilson

Chapter 19. Role of Oxidative Stress in the Pathogenesis and Progression of Coronary Artery Disease: An Overview
Sanjay Mishra, Surya Prakash Dwivedi, Ram B. Singh, Sergey Shastun, Maria Abramova, and Douglas W. Wilson

Chapter 20. Antioxidant Vitamins and the Heart
Teodora Handjieva-Darlenska, Krasimira Hristova, and Ram B Singh

Chapter 21. Perspectives on Health Risks and Benefits of Tea-Drinking: Cardiovascular Diseases
LR Juneja, K. Griffiths, DW Wilson, HS Buttar, RB Singh, F. De Meester, A. Wilczynska, and T. Takahashi

Chapter 22. The ‘West’ Has Made the Worst Model of Health and Pushing the World to the Slow Moving Disaster on Total Health
Toru Takahashi, RB Singh, Kuniaki Otsuka, RR Watson, DW Wilson, and Fabien De Meester

Chapter 23. Echocardiographic Predictors of Early Postoperative Atrial Fibrillation in Coronary Artery Bypass Surgery Patients
Iana Simova, Tzvetana Katova, Anelia Nesheva, Krasimira Hristova, Velislava Kostova, Lyudmil Boyadzhiev, and Nikolay Dimitrov

Chapter 24. Association of Left Ventricular Hypertrophy in Patients with Hypertension
Ratindra Nath Mondal, Md. Jahedul Islam, Md. Ashraful Haque, Shah Md. Sarwer Jahan, Mahfuzer Rahman, A.B.M. Mobasher Alam, Muhammad Mahbub Hussain, Md. Kumruzzaman Sarker, Md. Haripada Sarkar, Moni Rani, B. D. Bidhu, Md. Atiqul Islam, Amaresh Chandra Shaha, Md. Noor Islam, Md. Zakir Hossain, and Ram B. Singh

Chapter 25. Micro-RNA in Cardiovascular Diseases
Rakesh Sharma, Thakur Hemnani, Aditya K Gupta, Ram B. Singh, Teodora Handjiev Darlenska, and Krasimira Hristova

Chapter 26. Angiotensin Converting Enzyme: A Possible Risk Promoter during Transition from Undernutrition to Chronic Diseases of Affluence
Ram B Singh, Jan Fedacko, Daniel Pella, Krasimira Hristova, Hilton Chaves, Branislav Milovanovic, Teodora H. Darlenska, Toru Takahashi, Fabien De Meester, Douglas W Wilson, Galal Elkilany, and Sherif Baathallah

Chapter 27. Sugar and the Heart
Jan Fedacko, Viola Vargova, Daniel Pella, RB Singh, AK Gupta, LR Juneja, Fabien De Meester, and DW Wilson

Chapter 28. Diet and Hypertension
Sergey Shastun, Maria Abramova, RB Singh, Krasimira Hristova, and Galal EN Elkilani

Chapter 29. Short Term Predictors of Mortality among Patients with Hemorrhagic Stroke
Ratindra Nath Mondal, Susanto Barman, Md. Jahedul Islam, Shah Md. Sarwer Jahan, ABM Mobasher Alam, Muhammad Mahbub Hussain, Md. Kumruzzaman Sarker, Md. Mahfuzer Rahman, Haripada Sarkar, Moni Rani, Jimma Hossain, AKM Nurunnobi, B. D. Bidhu, Md. Zakir Hossain, Md Atiqul Islam, S.M. Rahman, and Ram B. Singh

Chapter 30. The French Paradox and the Russian Paradox
Sergey A Shastun, Sergey Chibisov, Maria Abramova, Ram B Singh, Toru Takahashi, Pavel Khochunsky, and Pratik Velangi

Chapter 31. In Memoriam
Shanti S. Rastogi, MBBS, MD, FRCP, FICN, FICC

Chapter 32. In Memoriam
Frank Columbus


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