Chronobiologic Reference Values for Blood Pressure during Pregnancy


Authors: Germaine Cornelissen and Jarmila Siegelova
Page Range: 183-191
Published in: World Heart Journal, 15#3 (2023)
ISSN: 1556-4002

Table of Contents


Changes in blood pressure (BP) during the course of pregnancy are revisited based on ambulatory monitoring (ABPM) from 223 pregnant women who contributed 362 records of around-the-clock measurements covering 2 days. Retrospectively, data from women with uncomplicated pregnancies were used to derive time-specified reference values. Circadian rhythm characteristics were also compared between pregnancies complicated by gestational hypertension (G-MH), MESOR-Hypertension (MH) or pre-eclampsia (PE) and uncomplicated (healthy) pregnancies. In clinical health, blood pressure decreases during the second trimester of pregnancy before increasing again to reach pre-pregnancy values at term. The rhythm-adjusted average (MESOR) of systolic BP is elevated in G-MH, MH, and PE, even before these conditions were clinically diagnosed. Chronobiologically-interpreted ABPM in pregnancy can identify complications early, and prompt the timely institution of countermeasures when needed.

Keywords: blood pressure, circadian rhythm, gestation, pregnancy, reference values

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