Chronic Liver Disease: From Molecular Biology to Therapy

JC Perazzo, Francisco Eizayaga, Salvador Romay, Carlos E. Brodersen, Alberto E. Muñoz and Néstor R. Lago (Editors)
Laboratory of Hepatic Encephalopathy and Portal Hypertension, Centre of Experimental Pathology, Department of Pathology, Buenos Aires, Argentina

Series: Hepatology Research and Clinical Developments
BISAC: MED114000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Chronic liver disease is one of the most prevalent diseases in the developed world. The large amount of new knowledge has resulted in subspecialities, even in issues such as hepatology. Thus everyday, it is more difficult to access all relevant information that is being published. Additionally, biomolecular techniques lead to a level of complexity that is only beneficial when dealt with by professionals.

This book attempts to give a broad overview of the molecular biology of the liver, emphasizing how this knowledge is the basis of further treatment. Thus, pathophysiology and therapies are updated in viral hepatitis, hepatic encephalopathy and portal hypertension, among others. However, appended issues that apparently are less relevant such as the stem cell and endocannabinoids are included. These two issues will soon be of importance due to their close relationship with the liver tissue and especially with liver disease.
There are also new paradigms such as cell death and the implication of the extracellular matrix, which are also addressed. In addition, important issues such as the stellate cells and their intimate relationship with fibrogenesis are treated in-depth. Also the fundamental role of endothelin in chronic liver disease is examined. Because of its prevalence, NASH was discussed with special interest, with a focus on the process from fatty liver to molecular biology of liver cells and metabolism in chronic liver disease. The authors believe that this is a broad vision that describes the basic pathophysiological mechanisms shared by many liver diseases, giving rational support for specific therapies.
(Imprint: Nova Biomedical)

List of Contributors

Preface

Acknowledgements

Abstract

Chapter 1. Cell Death Issue for Researchers and Clinicians
Pamela Valva, Mario Alejandro Lorenzetti and María Victoria Preciado (Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP- CONICET-GCBA) Laboratorio de Biología Molecular, División Patología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina)

Chapter 2. Hepatic Stellate Cells in Liver Sinusoid Function
Luís Perea, Júlia Vallverdú, Alberto E. Muñoz, and Pau Sancho-Bru (Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain, and others)

Chapter 3. Liver Sinusoidal Endothelial Cells: From Liver Function to Liver Cirrhosis
Alberto E. Muñoz and Luís Perea (Sección de Hepatología, Hospital de Gastroenterología Dr. Carlos B. Udaondo, Buenos Aires, Argentina, and others)

Chapter 4. Hyperammonemia and Hyperammonemic Conditions
Pablo A Souto and Lisandro Orbea (Laboratory of Hepatic Encephalopahy & Portal Hypertension. Faculty of Pharmacy and Biochemistry. University of Buenos Aires, Argentina, and others)

Chapter 5. Cannabinoids: Implications in Liver Disease
Laura Caltana and Alicia Brusco (Universidad de Buenos Aires, Consejo Nacional de lnvestigaciones Científicas y Técnicas, Instituto de Biología Celular y Neurociencia (IBCN), Facultad de Medicina, Buenos Aires, Argentina)

Chapter 6. Extracellular Matrix-Liver Relationship
Néstor R. Lago, Ariel Marcotegui, Lisandro Orbea, Pablo A. Souto, and Juan C Perazzo (Center of Experimental and Applied Pathology, Department of Pathology, Faculty of Medicine, University of Buenos Aires, Argentina, and others)

Chapter 7. Endothelins in Liver Health and Disease
Myrian R. Rodriguez, María Julia Guil, Luis Cassinotti, Yanina Bota, Mercedes Scholler, Marcelo S. Vatta, and Liliana Bianciotti (Instituto de Inmunología, Genética y Metabolismo (INIGEM- CONICET-UBA), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina, and others)

Chapter 8. Hepatitis B Virus
Diego Flichman (Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina)

Chapter 9. Chronic Hepatitis B: Current Treatment and New Therapeutic Options
Maria Gimena Fernandez (Hepatologist of the Churruca Hospital, Buenos Aires, Argentina)

Chapter 10. Hepatitis C Virus
Pamela Valva, Mario Alejandro Lorenzetti and María Victoria Preciado (Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas, (IMIPP- CONICET-GCBA) Laboratorio de Biología Molecular, División Patología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina)

Chapter 11. Mechanism Lipotoxicity in the Progression from Fatty Liver to Non-Alcoholic Steatohepatitis
Fernando J. Barreyro and Juan José Poderoso (Laboratory of Microbiology, Faculty of Chemical and Natural Sciences, National University of Misiones, Argentina, and others)

Chapter 12. Portal Hypertension
Francisco Eizayaga, Leandro Steinberg, Carlos Brodersen, and Salvador Romay (Laboratory of Hepatic Encephalopathy and Portal Hypertension, Department of Pathophysiology, University of Buenos Aires, Ciudad de Buenos Aires, Argentina, and others)

Chapter 13. Pathophysiology of Portal Hypertension =
Salvador Romay, Leandro Steinberg and Francisco Eizayaga (Lab. of Hepatic Encephalopathy and Portal Hypertension, Department of Pathophysiology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina, and others)

Chapter 14. Hepatic Encephalopathy
Silvina Tallis (Laboratory of Hepatic Encephalopathy and Portal Hypertension, Department of Pathophysiology, University of Buenos Aires, Ciudad de Buenos Aires, Argentina)

Chapter 15. Hepatic Encephalopathy Therapy
Sara Beatriz Chao (Hepatologist at the Gastroenterology Division in President Perón Hospital from Avellaneda, Buenos Aires, Argentina)

Chapter 16. The Role of Systemic Inflammation in Encephalopathy Consequence of Chronic Liver Failure
Ariel R. Marcotegui, Soraya Wilke Saliba, Nizar Yousif, and Bernd Fiebich (Laboratory of Hepatic Encephalopathy and Portal Hypertension, Department of Pathophysiology, University of Buenos Aires, Ciudad de Buenos Aires, Argentina, and others)

Chapter 17. Hyperammonia and Skeletal Muscle
Lisandro Orbea, Ariel R. Marcotegui, Pablo A. Souto, Juan Skerl, and Juan C. Perazzo (Laboratory of Hepatic Encephalopathy and Portal Hypertension, Department of Biological Science, Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Ciudad de Buenos Aires, Argentina, and others)

Chapter 18. Cellular Therapies to Approach Severus Liver Pathologies
Gustavo A. Moviglia (Director of the Center of Investigation and Engineering of Tissues and Cellular Therapy, Maimonides University, Buenos Aires, Argentina)

Index

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