Chronic Granulomatous Disease: Genetics, Biology and Clinical Management

Reinhard A. Seger, Dirk Roos, Brahm H. Segal and Taco W. Kuijpers
Division of Immunology, University Children`s Hospital of Zürich, Zürich, Switzerland

Series: Immunology and Immune System Disorders
BISAC: MED044000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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This is the first e-book on Chronic Granulomatous Disease (CGD). This book is meant for everyone involved in the diagnosis, treatment or guidance of patients with this disease, as well as for the patients and their parents/caretakers, investigators and students experiencing this disease.

The authors hope that this book will help everybody involved to gain more knowledge about the cause of CGD, the symptoms and the treatment of the patients in various geographical regions to help to improve their lives.

The authors have invited experts in the various aspects of CGD (fellow authors) to write chapters on their specialty, and have sent these chapters to other specialists (the contributors) for comments and additions.
(Imprint: Nova Biomedical)


About the Authors and Contributors

Section I Biochemistry and Signaling Functions of NADPH Oxidase

Chapter 1. Biochemistry of the Leukocyte NADPH Oxidase

Chapter 2. NADPH Oxidase-Mediated Antimicrobial Activity: When Do We Need It?

Chapter 3. Dysfunctional Processes Regulating IL-1β in Chronic Granulomatous Disease

Section II Clinical Presentation and Diagnosis of CGD

Chapter 4. Bacterial and Fungal Infections in Chronic Granulomatous Disease

Chapter 5. Endemic Infections in Chronic Granulomatous Disease

Chapter 6. Inflammatory Manifestations in Chronic Granulomatous Disease

Chapter 7. Clinical Manifestations in X-Linked Carriers of Chronic Granulomatous Disease

Chapter 8. Biochemical and Genetic Diagnosis of Chronic Granulomatous Disease

Section III Management

Chapter 9. Checklists for Clinicians: Major Complications in CGD: How to Proceed

Chapter 10. Allogeneic Hematopoietic Stem Cell Transplantation

Chapter 11. Resources – Chronic Granulomatous Disease Websites

Section IV Research

Chapter 12. Gene Therapy for CGD

Chapter 13. Chronic Granulomatous Disease – Quality of Life Studies

Chapter 14. Future Directions in CGD Research


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