Chromatographic Methods and Research

$195.00$305.00

Raven W. Obrien (Editor)

Series: Analytical Chemistry and Microchemistry
BISAC: SCI013010

This book contains six chapters that detail chromatographic methods and research. Chapter One discusses how liquid chromatography-ultraviolet (LC-UV) bioanalytical methods can be considered an important tool for beta-lactams serum measurements to evaluate in a real time drug effectiveness in septic burn patient’s bedside. Chapter Two focuses on the preconcentration strategies coupled with chromatographic methods used for the detection of various types of organic compounds. Chapter Three details the bioanalytical methods, based on liquid chromatography, for the therapeutic drug monitoring of combined therapies of antibiotics in pediatric burns. Chapter Four presents liquid chromatography-tandem mass spectrometry. Chapter Five briefs about the determination of an antiviral drug, favipiravir (FVPR) in pure and pharmaceutical dosage forms and different biological matrix of samples, by employing various chromatographic techniques. Lastly, Chapter Six outlines key considerations for the analysis of the hormone α-MSH in brain tissue by the liquid chromatography tandem mass spectrometry (LC-MS/MS) method.

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Table of Contents

Preface

Chapter 1. Beta-Lactam Agents Serum Measurements by Liquid Chromatography to Evaluate Meropenem and Piperacillin Effectiveness in Septic Burn Adults with a Pharmacokinetic-Pharmacodynamic Approach
Leonard de Vinci Kanda Kupa1, PhD, Vanessa Kasubeck de Souza1, PhMs, Thais Vieira Camargo1, PhMs, Claudia Garcia Messiano1, PhMs, Ronaldo Morales Junior1, PhD, Valentina Porta1, PhD, Mauricio Yonamine2, PhD, Beatriz Aparecida Passos Bismara Paranhos2, PhD, Aline Sandré Gomides Abad3, BS, Gabriela Aparecida Ferreira3, BS, Edvaldo Vieira de Campos3, MD, Élson Mendes da Silva Junior3, MD, João Manoel da Silva Junior3, MD, Debora Cristina Sanches Pinto3, MD David de Souza Gomez3, MD, and Silvia Regina Cavani Jorge Santos1, PhD
1Clinical Pharmacokinetics Center, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
2Department of Clinical-Toxicology Analysis, Multi-User Laboratory of Analytical Center, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
3Plastic Surgery and Burns Division of Clinics Hospital, Surgery Department of Medical School, University of Sao Paulo, Sao Paulo, Brazil

Chapter 2. Preconcentration Strategies Coupled with Chromatographic Methods for the Determination of Organic Compounds
Raif İlktaç
Application and Research Center for Testing and Analysis, University of Ege, Bornova, İzmir, Turkey

Chapter 3. Bioanalytical Methods Based on Liquid Chromatography for the Therapeutic Drug Monitoring of Combined Therapies of Antibiotics in Pediatric Septic Major Burns
Silvia Regina Cavani Jorge Santos1, PhD, Thais Vieira Camargo1, MS, PhD, Leonard de Vinci Kanda Kupa1, PhD, Ronaldo Morales Junior1, PhD, Claudia Garcia Messiano1, MS, Vanessa Kasubeck de Souza1, MS, Frederico Ribeiro Pires1, MD, Aline Sandre2, BS, Gabriela Aparecida Ferreira2, BS, Edvaldo Vieira de Campos2, João Manoel da Silva Junior2, MD, Débora Cristina Sanches Pinto2, MD, and David de Souza Gomez2, MD
1Clinical Pharmacokinetics Center, University of Sao Paulo, Sao Paulo, Brazil
2Plastic Surgery and Burns Division of Clinics Hospital, Surgery Department of Medical School, University of Sao Paulo, Sao Paulo, Brazil

Chapter 4. Liquid Chromatography-Tandem Mass Spectrometry for Simultaneous Piperacillin-Meropenem Serum Measurements in Septic Burns for Effectiveness
Paschoalina Romano1, PhD, Pérsio de Almeida Rezende Ebner1, BS, Marc Yves Chalom1, BS, Maria Severina dos Santos1, BS, Marcio Santos Garcia1, BS, Kupa Leonard de Vinci Kuppa Kanda2, PhD, Nairo Massakazu Sumita1, PhD, Nilo José Coêlho Duarte1, MD, Aline Sandre, BS, Gabriela Aparecida Ferreira3 BS, Joao Manoel da Silva Junior3, MD, Thais Vieira de Camargo3, PhMS, Ronaldo Morales Junior3, David de Souza Gomez3, MD and Silvia Regina Cavani Jorge Santos3, PhD
1Central Laboratory Division and Medical Investigation Laboratory (LIM 03) – Medical School, University of Sao Paulo (HCFMUSP)
2Medical investigation Laboratory (LIM 17), Medical School, University of Sao Paulo, Sao Paulo, Brazil

Chapter 5. A Brief Review of Chromatographic Methods for the Quantification of Favipiravir
I. M.Nandeesha1, MSc, G.Nagalakshmi2, PhD, K.Umesha3, PhD, B. C.Yallur1, PhD, T. M.Veeresha4, PhD and D. H. Manjunatha5, PhD
1Department of Chemistry, MS Ramaiah Institute of Technology, Bengaluru, Karnataka, India
2Department of forensic science, Soundarya Institute of management and Science, Bengaluru, Karnataka, India
3PG Department of Chemistry, Vijaya College, Bangalore, Karnataka, India
4Department of Chemistry, Vijayanagar College, Hosapete, Vijayanagara, Karnataka, India
5Deparment of Studies in Chemistry, Shivagangotri, Davangere University, Davangere, Karnataka, India

Chapter 6. Advances in Quantitative Liquid Chromatography-Mass Spectroscopy for Central Nervous System Melanocortin Hormone Quantification
Renée Onnainty1, PhD, Guadalupe Herrera2, PhD, and Gladys E. Granero1, PhD
1Unidad de Investigaciones y Desarrollo en Tecnología Farmacéutica (UNITEFA) – ONICET, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
2IFEC-CONICET, Depto. Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

Index

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