Cholangiocarcinoma

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Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

Cholangiocarcinoma presents a challenge for cancer specialists all over the world. Neoplasia of the biliary tract are rare, accounting for approximately 3% of all gastrointestinal tumours with an incidence of about three per 100,000; but rates have been rising rapidly in recent years. This cancer is one of the major killers: at the time of diagnosis, less than 30% of patients are candidates for complete resection. For unresectable cholangiocarcinomas, median survival is less than one year. Given the rarity of the disease, the literature on cholangiocarcinomas is scant. However, the increasing incidence of this highly lethal malignancy should capture the attention of physicians and stimulate further research.

Designed for specialists, this book highlights the main clinicopathologic features of cholangiocarcinoma and is an essential clinical guide for oncologists, surgeons, radiotherapists, radiologists, gastroenterologists and all physicians taking care of patients with biliary tract cancers. This book offers an expert overview of the disease starting from the embryology and anatomy of the biliary tree. Each chapter provides a detailed up-to-date description of etiopathogenetic factors, epidemiology, histopathology, molecular biology and staging, emphasizing clinical features and standard approaches to biliary tract cancer, with a summary of recent literature evidence. The book also covers the diagnostic work-up and outlines the current status of imaging techniques with an overview of recent advances in surgery and locoregional and systemic therapy, in addition to the follow-up and palliative care of cholangiocarcinoma patients. (Imprint: Nova Biomedical)

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Table of Contents

Table of Contents

Preface

Cholangiocarcinoma: Introduction
(Yuji Nimura, Aichi Cancer Center, Kanokoden, Chikusa-ku, Nagoya, Japan)

Surgical Anatomy of the Biliary Tract
(Alessandro Cucchetti, Federico Mazzotti, Department of Medical and Surgical Science, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

New Insights into Epidemiology of Cholangiocarcinoma
(Vincenzo Cardinale, Maria Consiglia Bragazzi, Domenico Alvaro, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Sapienza University of Rome, Rome, Italy, and others)

Risk Factors of Cholangiocarcinoma
(Andrea Farioli, Giovanni Brandi, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy, and others)

Molecular Biology of Cholangiocarcinoma
(Leslie Farber, Apinya Jusakul, Sarinya Kongpetch, Choon Kiat Ong, and Bin Tean, The National Cancer Centre of Singapore, Singapore)

Carcinogenesis of Cholangiocarcinoma
(Simona Tavolari, Michela Venturi, Giovanni Brandi, Haematological and Oncological Institute, Department of Experimental, Diagnostic and Specialty Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy)

Histopathology of Cholangiocarcinoma
(Francesco Vasuri, Deborah Malvi, Antonia D’Errico-Grigioni, ‘F. Addarii’ Institute of Oncology and Transplant Pathology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

Staging of Cholangiocarcinoma
(Rita Golfieri, Salvatore Ascanio, Cristina Mosconi, Matteo Renzulli, Radiology Unit, Department of Digestive Disease and Internal Medicine, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

Clinical Features of Intrahepatic Cholangiocarcinoma
(Vincenzo Cardinale, Manuela Gatto, Domenico Alvaro, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Sapienza University of Rome, Rome, Italy, and others)

Extrahepatic Cholangiocarcinoma: Clinical Features
(Davide Festi, Eleonora Scaioli, Antonio Colecchia, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy)

Circulating Biomarkers
(Massimo Gion, Chiara Trevisio, Giulia Rainato, Aline S.C. Fabricio, Centro Regionale Specializzato Biomarcatori Diagnostici Prognostici e Predittivi, Dipartimento di Patologia Clinica – Azienda ULSS Veneziana, Venezia, and others)

Ultrasonography (US) / Contrast-Enhanced Ultrasonography (CEUS) for Cholangiocarcinoma
(Elisabetta Sagrini, Laura Venerandi, Federico Stefanini, Fabio Piscaglia, Div. of Internal Medicine, Dpt. of Medical and Surgical Sciences DIMEC, University of Bologna S. Orsola-Malpighi Hospital, Bologna, Italy)

Endoscopic Retrograde Cholangiopancreatography (ERCP) and Echoendoscopy for Cholangiocarcinoma
(Vincenzo Cennamo, Marco Bassi, Carlo Fabbri, Gastrointestinal and Digestive Endoscopy Unit, Surgical Department, AUSL Bologna, Largo Nigrisoli, Bologna, Italy)

Percutaneous Transhepatic Cholangiography (PTC) for Cholangiocarcinoma
(Rita Golfieri, Cristina Mosconi, Salvatore Ascanio, Matteo Renzulli, Radiology Unit, Department of Digestive Disease and Internal Medicine, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) for Cholangiocarcinoma
(Rita Golfieri, Beniamino Corcioni, Cristina Mosconi, Matteo Renzulli (Radiology Unit, Department of Digestive Disease and Internal Medicine, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

Positron Emission Tomography (PET) for Cholangiocarcinoma
(Stefano Fanti, Hanna Svirydenka, Elena Tabacchi, Department of Nuclear Medicine, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy)

Surgical Treatment for Intrahepatic Cholangiocarcinoma
(Giorgio Ercolani, Alessandro cucchetti, Michela Cucchi, Matteo Cescon, Massimo De Gaudio, Matteo Ravaioli, Antonio D. Pinna, Department of Medical and Surgical Science, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

Surgical Treatment for Hilar Cholangiocarcinoma
(Mizuno T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nagino M., Nagoya University Graduate School of Medicine, Japan)

Lymphadenectomy for Cholangiocarcinoma
(Matteo Ravaioli, Lorenzo Maroni, Flavia Neri, Antonio D. Pinna, Department of Medical and Surgical Science, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

Portal Vein Embolization and Cholangiocarcinoma
(Massimo Del Gaudio, Matteo Cescon, Alberto Balduzzi, Giorgio Ercolani, Department of Medical and Surgical Science, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

Associating Liver Partition with Portal Vein Ligation for Staged Hepatectomy (ALPPS) for Cholangiocarcinoma?
(Matteo Cescon, Massimo Del Gaudio, Antonio Daniele Pinna, Department of Medical and Surgical Science, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

Liver Transplantation for Cholangiocarcinoma
(Nataliya Razumilava, Julie K. Heimbach, Charles B. Rosen, and Gregory J. Gores, Division of Gastroenterology and Hepatology, Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA)

Radiotherapy and Brachytherapy for Unresectable Cholangiocarcinoma
(Andrea Galuppi, Alessio G. Morganti, Silvia Cammelli, and Rezarta Frakulli, Unit of Radiation, S. Orsola Malpighi Hospital, Bologna, Italy, and others)

Transarterial Chemoembolization (TACE)
(Thomas J. Vogl, Mohammad A. Bokhary, Stefan Zangos, Bita Panahi, Institute for Diagnostic and Interventional Radiology, University Hospital Frankfurt, Johann Wolfgang Goethe University, Frankfurt am Main, Germany)

Radiofrequency Ablation (RFA) for Unresectable Cholangiocarcinoma
(Carla Serra, Andrea Imbrogno, Cristina Felicani, Department of Organs Failure and Transplantation, St. Orsola-Malpighi Hospital, Italy, and others)

Yttrium-90 Microsphere Radioembolization for Unresectable Cholangiocarcinoma
(Cristina Mosconi, Matteo Renzulli, Federica Ciccarese, Rita Golfieri, Radiology Unit, Department of Digestive Disease and Internal Medicine, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy)

Photodynamic Therapy in Cholangiocarcinoma
(Janaki Patel, Nada Rizk BS, Michel Kahaleh, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, NY)

Chemotherapy in Patients with Advanced Cholangiocarcinoma
(Giovanni Brandi, Giorgio Frega, Aurelia Barbera, Andrea Palloni, Haematological and Oncological Institute, Department of Experimental, Diagnostic and Specialty Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy)

Targeted Therapies for Cholangiocarcinoma
(Angela Lamarca, Jorge Barriuso, Juan W Valle, Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK, and others)

Adjuvant Treatment and Follow-Up Strategies
(Giovanni Brandi, Stefani De Lorenzo, Jody Corbelli, Haematological and Oncological Institute, Department of Experimental, Diagnostic and Specialty Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy)

Palliative Care for Cholangiocarcinoma
(Nicole Brighi, Guido Biasco, Academy of Sciences of Palliative Medicine, Bentivoglio, Bologna, Italy, and others)

Diagnostic and Therapeutic Algorithms for Cholangiocarcinoma
(Giovanni Brandi, Michela Venturi, Giorgio Ercolani, Haematological and Oncological Institute, Department of Experimental, Diagnostic and Specialty Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy, and others)

Index

Audience: Designed for specialists, this volume highlights the main clinicopathologic features of cholangiocarcinoma and is an essential clinical guide for oncologists, surgeons, radiotherapists, radiologists, gastroenterologists and all physicians taking care of patients with biliary tract cancers.

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