Cholangiocarcinoma: From Diagnosis to Treatment


Dario Ribero, MD (Editor)
Director, Division of Hepatobiliary and Pancreatic Surgery, European Institute of Oncology, Milan, Italy

Timothy M. Pawlik, MD (Editor)
Johns Hopkins Medicine Liver Tumor Center Multi-Disciplinary Clinic, Johns Hopkins Hospital, Baltimore, MD, USA

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

Cholangiocarcinoma is a heterogeneous group of neoplasms, which has a rising worldwide incidence. Therefore, it is now a major cause of cancer mortality. Diagnosis, staging, treatment approaches and outcomes differ significantly based on the location of the tumor. Given the challenges of remaining up-to-date in a rapidly expanding field, the aim of this monograph is to provide a comprehensive, fully referenced presentation of the state-of-the-art medical and surgical aspects relevant to the management of cholangiocarcinoma divided by the site of origin (i.e. intrahepatic, hilar and distal).

The division of the book into these sections reflects the biological and clinical differences between these tumor types and will permit the authors to address the diagnostic, interventional or treatment issues specific to each tumor type. By presenting all medical and surgical aspects of cholangiocarcinoma in a systematic manner, this monograph will be a ready-to-use instrument for those interested in cholangiocarcinoma, including practicing physicians, residents, fellows and specialists. A list of 66 world-renowned experts contributed to the book, offering the readers the unique opportunity to have a broad perspective on these diseases, practical indications on patient selection and treatment that can be easily applied to both Eastern and Western clinical settings.
(Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Section 1: Intrahepatic Cholangiocarcinoma

1 Epidemiology of Intrahepatic Cholangiocarcinoma

(Shen Feng and Wu Lu, The Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China)

2 Pathology of Intrahepatic Cholangiocarcinoma

(Yasuni Nakanuma and Yuko Kakuda, Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan)

3 Molecular Biology of Intrahepatic Cholangiocarcinoma

(Jesper B Andersen, Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark)

4 Diagnostic Imaging of Intrahepatic Cholangiocarcinoma

(Katie C. Nicholas, Neda Rastegar, Timothy M. Pawlik and Ihab R Kamel, The Russell H. Morgan Department of Radiology and Radiological Sciences and the Department of Surgery, Johns Hopkins University, Baltimore, Maryland, USA)

5 Staging of Intrahepatic Cholangiocarcinoma

(Lauren Postlewait and Shishir K. Maithel, Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA)

6 Surgery for Intrahepatic Cholangiocarcinoma

(Kelly Olino and Michael D’Angelica, Memorial Sloane-Kettering Cancer Center, New York, NY, USA)

7 Systemic Therapy for Intrahepatic Cholangiocarcinoma

(Dawn Q. Chong and Andrew X. Zhu, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA, and others)

8 Intra-Arterial Therapy for Intrahepatic Cholangiocarcinoma

(Lynn Jeanette Savic, Julius Chapiro and Jean-François Geschwind, Russell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins Hospital, Baltimore, USA)

9 Radiation therapy for Intrahepatic Cholangiocarcinoma

(Florence K. Keane and Theodore S. Hong, Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA, USA, and others)

10 Ablative Therapies for Intrahepatic Cholangiocarcinoma

(Devin C. Flaherty and Anton J. Bilchik, Department of Surgical Oncology, John Wayne Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA, USA)

Section 2: Hilar Cholangiocarcinoma

11 Epidemiology of Hilar Cholangiocarcinoma

(Mehtan Ahmed, Mireille B. Toledano and Shahid A. Khan, Imperial College London, UK)

12 Histopathology of Hilar Cholangiocarcinoma

(Laura Rubbia-Brandt and Benoit Terris, Division of clinical pathology, Geneva University Hospital and Faculty of medicine of Geneva, Switzerland, and others)

13 Molecular Biology of Hilar Cholangiocarcinoma

(Robert A. Anders, Department of pathology of The Johns Hopkins University School of Medicine, Baltimore, MA, USA)

14 Hilar Cholangiocarcinoma: Diagnostic Imaging

(Maxime Ronot, Matthieu Lagadec, Romain Breguet and Valérie Vilgrain, Department of Radiology, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine, France)

15 Interventional Radiology for Hilar Cholangiocarcinoma

(Kyungmouk S. Lee, Anne M. Covey and David C. Madoff, Department of Radiology, Division of Interventional Radiology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA, and others)

16 Endoscopic Management of Hilar Cholangiocarcinoma

(Vincent Huberty and Jacques Deviere, Medical-Surgical Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium)

17 Staging for Hilar Cholangiocarcinoma

(Yoshihiro Mise and Jean-Nicolas Vauthey, The M.D. Anderson Cancer Center, Houston, TX, USA)

18 Surgery for Hilar Cholangiocarcinoma

(Daniel Seehofer and Peter Neuhaus, Department of General-, Visceral- and Transplantation- Surgery, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany)

19 Liver Transplantation for Hilar Cholangiocarcinoma

(Audrey E. Ertel and Shimul A. Shah, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, USA)

20 Systemic Therapy for Hilar Cholangiocarcinoma

(David P. Cosgrove, Department of Internal Medicine, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA)

21 Traditional and Novel Chemotherapy and Radiation Approaches to Hilar Cholangiocarcinoma

(Christopher H. Crane, Micheal G. Haddock, Yerko O. Borghero and Brian G. Czito, Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA, and others)

Section 3: Distal Cholangiocarcinoma

22 Epidemiology of Distal Cholangiocarcinoma

(Jean M. Butte and Elijah Dixon, Division of General Surgery, Service of Hepatobiliary and Pancreatic Surgery, Foothills Medical Centre, University of Calgary, Calgary, AB, Canada, and others)

23 Pathology of Distal Cholangiocarcinoma

(Benjamin Goeppert and Peter Schirmacher, Institute of Pathology, University Hospital Heidelberg, Germany)

24 Computed Tomography and Magnetic Resonance Imaging of Distal Cholangiocarcinoma

(Siva P. Raman and Elliot K. Fishman, Johns Hopkins University, Department of Radiology, Baltimore, Maryland, USA)

25 Endoscopy for Distal Cholangiocarcinoma

(Robert Moran and Zhiping Li, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland, USA)

26 Staging of Distal Cholangiocarcinoma

(Gregory Larrieux and Thomas C. Gamblin, Department of Surgery, Medical College of Wisconsin, Milwaukee WI, USA)

27 Surgery for Distal Cholangiocarcinoma

(Salvatore Paiella, Stefano Andrianello, Roberto Salvia and Claudio Bassi, University of Verona Hospital, General Surgery B Department, Istituto del Pancreas, Verona, Italy)

28 Systemic Therapy for Distal Cholangiocarcinoma

(Maria Ignez Braghiroli and Paulo M. Hoff, Instituto do Cancer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Brazil)

29 Radiation therapy for Distal Cholangiocarcinoma

(Lauren M. Rosati and Joseph M. Herman, Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA)


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