Characteristics of the Mitochondrial Permeability Transition in Brain Cortex Mitochondria

Juanita Bustamante (Editor)
Universidad Abierta Interamericana, Centro de Altos Estudios en Ciencias de la Salud, Buenos Aires, Argentina

Silvia Lores-Arnaiz (Editor)
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Fisicoquímica, Buenos Aires, Argentina
CONICET-Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Buenos Aires, Argentina

Series: Cell Biology Research Progress
BISAC: SCI017000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Mitochondria protect neurons from the deleterious effects of abnormal Ca2influx, which leads to the activation of hydrolytic and degradation pathways associated with apoptosis and necrosis. This new book presents different characteristics of the MPT in mouse non synaptic brain cortex mitochondria, as well as methodological approaches for MPT characterization. Respiratory function and production of reactive oxygen derived molecules, were analysed before and after calcium induction of MPT. Energized organelles after MPT induction with 100M Ca2+, showed mitochondrial depolarization and partial swelling that was maximal after addition of alamethicin. This book discusses the effect of NO on MPT and apoptotic cell death, as well as the role of MPT induction in brain pathology. (Imprint: Nova Biomedical)

ABSTRACT

INTRODUCTION

THEORETICAL BASIS OF THE PORE STRUCTURE

ANTs

VDAC

CypD

CHARACTERIZATION OF MPT

MITOCHONDRIAL RESPIRATORY FUNCTION IN MPT

HYDROGEN PEROXIDE PRODUCTION DURING CALCIUM-INDUCED MPT

NITRIC OXIDE AND MPT

MPT ROLE IN BRAIN CELL DEATH

CONCLUDING REMARKS

ACKNOWLEDGEMENTS

REFERENCES

INDEX

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