Juanita Bustamante (Editor)
Universidad Abierta Interamericana, Centro de Altos Estudios en Ciencias de la Salud, Buenos Aires, Argentina

Silvia Lores-Arnaiz (Editor)
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Fisicoquímica, Buenos Aires, Argentina
CONICET-Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Buenos Aires, Argentina

Series: Cell Biology Research Progress
BISAC: SCI017000

Mitochondria protect neurons from the deleterious effects of abnormal Ca2influx, which leads to the activation of hydrolytic and degradation pathways associated with apoptosis and necrosis. This new book presents different characteristics of the MPT in mouse non synaptic brain cortex mitochondria, as well as methodological approaches for MPT characterization. Respiratory function and production of reactive oxygen derived molecules, were analysed before and after calcium induction of MPT. Energized organelles after MPT induction with 100M Ca2+, showed mitochondrial depolarization and partial swelling that was maximal after addition of alamethicin. This book discusses the effect of NO on MPT and apoptotic cell death, as well as the role of MPT induction in brain pathology. (Imprint: Nova Biomedical)